Cellceutix Corporation (OTCQB:CTIX) is a cancer, anti-inflammatory and autism drug developer. Cellceutix has been in the news and attracting investor attention lately as developments with their lead drug, Kevetrin as a novel indication for a variety of drug-resistant cancers nears clinical trials after producing strong pre-clinical data. 

Leo Ehrlich, CEO of Cellceutix, conducted an exclusive interview with BioMedReports about his company’s leading drug candidate:Question: the latest news from Cellceutix announced a Notice of Approval for a clinical trial at a major cancer center.  Can you elaborate?The details will be disclosed in the coming weeks, but it is safe to say that the cancer center that has approved hosting the clinical trials was absolutely who we were hoping for.  while it has taken a bit longer than it would have if we would have elected a smaller hospital, the prestige of this facility adds a great deal of validation to our belief in Kevetrin’s potential.  It is a rarity that a small company such as ours would have the opportunity to have a trial at a world-renown cancer research center.  that can only be attributable to the promising data that resulted from the preclinical trials. We are excited to share more information in the near future.Question: one thing that seems to set Kevetrin apart from other cancer therapies is a breakthrough with p53.  Why is this significant?p53 is known as the “Guardian Angel” gene and a key component in regulating the cell cycle.  In more than half of all cancers, the p53 has lost all or a portion of its function which allows cancer cells to run rampant.  Researchers have known about the p53 correlation to carcinomas, but have yet been able to come-up with a solution to restore the function of p53.  there was a class of drugs called “Nutlins” a few years ago that believed to hold promise, but proved to be genotoxic – meaning that the drug damaged the hosts DNA – so that quickly was realized as not a viable option.  Kevetrin has proven to this point to restore p53 back to a normal status so it can do its job as master regulator and see to it that the cancer cells are destroyed without damaging any DNA.  It is truly a major breakthrough in cancer research.  We don’t know of any other pharmaceutical company that possesses, much less developed, a compound that can do what Kevetrin is doing with p53.Question: the Cellceutix Chief Scientific Officer, Dr. Krishna Menon, has quite a background in cancer research.  Could you tell us a bit more about him?Actually, our whole team has amazing credentials.  Dr. Emil Frei sits on our Advisory Board and holds a large list of accolades.  Dr. Frei is widely-regarded as the “man who cured childhood leukemia” and currently sits as the Physician in Chief Emeritus at Dana Farber, Harvard University’s cancer center as well as recently being the recipient of a lifetime achievement award from the American Association for Cancer Research.  Dr. Samuel Danishefsky is also an Advisory Board member and a globally-respected chemist and recipient of countless awards for his cancer research.  Dr. Menon has an extensive background in the development of successful cancer drugs.  He worked under Dr. Frei during his time at Dana Farber and eventually segued into a lead researcher in-vivo studies at Eli Lilly where he was awarded a Presidential Award for the key role he played in the development of Gemzar and Alimta, two of the most commonly-used cancer drugs still today.  Dr. Menon’s holds Kevetrin’s potential in very high regard and given his track record, it certainly adds credence to the possibilities.Question: With the potential of a major breakthrough in cancer treatment, have any major pharmaceutical companies contacted you regarding your research with Kevetrin?We have been contacted by some of the biggest pharma companies in the industry.  our poster presentation at the AACR meeting was a huge successes with our booth being one of the busiest that we have ever seen at a convention.  even though we aren’t at liberty to disclose the names, we have issued statements announcing that Confidential Disclosure Agreements have been signed.  In my experience, it is extremely rare for a major pharma to contact a company regarding any drug that is not yet in clinical trials, but we are in contact with several who appear quite interested in what we have in our pipeline.  In fact, it is not just Kevetrin, we have also signed a CDA regarding KM-391, another compound of ours that we feel holds a great deal of potential as a next-generation treatment for autism because it addresses the core issues in the brain, not merely the symptoms as current drugs do.Question: Because of the uniqueness of Kevetrin, a variety of opportunities could be presented with regards to the human trials that are not normally available for many biotechs.  Could you share your thoughts on the possibilities? That is exactly true that we may have some significant advantages being that Kevetrin is a new class of chemistry in medicine.  one of the single, most important facts is that we will be getting our target audience in Phase I; something that typically doesn’t happen.  Phase I is generally for testing safety of the drug, but because we will be getting terminal cancer patients, it provides us with the potential to show efficacy.  If that happens, many windows of opportunity open with regards to applying for priority review or FDA fast Track status which can exponentially expedite the pace of trials and possibly move us into advanced stage trials in the mid-term.  We are very optimistic about being able to replicate some of our pre-clinical trials that have demonstrated tumor growth delay and reduction in tumor volumes across a broad spectrum of strains of cancer and are excited to get into the clinical trials to see if our contentions are validated.Question: Clearly Kevetrin is your flagship compound and you briefly touched on KM-391.  What else is in your pipeline?In all honesty, we feel that our pipeline rivals many of our Big Board competitors. We have a total of 8 compounds in our portfolio including Kevetrin and KM-391.  We have already conducted early research on KM-391 as an indication for the core issues of autism and have seen promising results.  As Kevetrin moves into human trials, we will be turning our attention back to KM-391 as there is a huge area of unmet medical need in that arena and represents potentially billions in revenue.  We also have a very promising psoriasis drug, KM-133, which is a small molecule that has shown very promising research as well.  our latest testing in a mouse model against a commonly-used treatment, methotrexate, demonstrated KM-133 outperforming the standard therapy with no reoccurrence of the psoriasis being shown.  We will also be turning our attention back to KM-133 in the near term as well as we have received some very significant interest in it as well. 

Paranoid schizophrenia is a form of mental disorder. this type of affection is also one of the most common that people have with them a distrust of everyone and everything and I believe that someone or something is there for them. this is a brain disorder that affects not only the patient but the relatives. Affecting the perception people exposed this disease, which affects social interaction is very patient, thought process, logic and perception of the real world.

These symptoms specify the presence of abnormal thinking and perception is not reality-oriented. The first symptoms is a delusion. For people with paranoid schizophrenia, delusion is primarily focused on the idea that involves damage to himself. The mis-interpretation of the brain leads to false ideas that are contrary to actual events. Examples of what is the belief that someone is stalking you, or someone has put poison in his food. Delusions of grandeur are also reflected commonly characterized by ideas that can fly, or you’re a celebrity. Violence and aggression, delusions also occur as they believe the people around you can hurt or harm. On the other hand, auditory hallucinations are also believed to be seen between patients with paranoid schizophrenia. The perception of voices that are truly defines absent auditory hallucination. The voices may be one to many, either the patient or talking with one another, often undesirable. these critical voices that can give actions or thought, or it may be harassment in nature. The voice command and also instruct the patient to harm himself or others. The voices may be perceived as real by the patient and talk or yell back to the voices usually occurs.

Paranoid Schizophrenia Diagnose

There are many ways, or diagnosis of schizophrenia symptoms, but more debilitating is paranoid schizophrenia. It is believed that the mental thought most widespread and chronic and can cause distortion of perception. People with schizophrenia do not have the ability to reason and interact with others. often, seeing or hearing things that don’t really exist.  Paranoid schizophrenia disease is often thought of as a multiple personality disorder. A person with symptoms of paranoid schizophrenia experience periods of remission that often go for long periods without symptoms of disease before a relapse. this mental disorder is manifested as a rigid model and persistent paranoia, mistrust, doubt and lack of sympathy toward others. Symptoms of Schizophrenia patients have constant feelings of being watched by someone or persecuted. these behaviors can have a huge impact on a person’s ability to build lasting relationships with others.Group Therapy is Ways to Treat Paranoid Schizophrenia

Many people with this disorder are teenagers and young adults who are in denial of a “time, and usually feel ashamed. this mental disorder can be controlled, however, requires constant care and depth, like many other diseases. Antipsychotic drugs are used to reduce hallucinations and thought disorder, but have no effect on the social isolation that often the first sign of disease.

Psychotherapy is one of the most effective ways to treat emotional and social problems associated with paranoid schizophrenia. Some patients in group therapy are very useful because it allows people to interact with paranoid schizophrenia and, ultimately, creates opportunities for socializing. Support for families and friends are important to help patients. Note that you can be very sensitive. The more you press to make something is about to retire and give a strange feeling that you are a hostile enemy who try to harm them. and effective treatment programs can help patients learn to deal with it.

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These days, acupuncture, which is an Asian remedy, is being extremely utilised in look for depressive disorders treatment. in Canada, people who suffer from this or people that have depressed acquaintances are suggested to attend acupuncture in Toronto. It is the use of needles to activate the neurons in the body. Since depressive disorders is a mind condition, acupuncture can actually support so much. There are doctors along with other medical professionals who even suggest their sufferers to attend an acupuncture medical center.

Having issues is part in our everyday lives. Via the a long time that Lord presented us the gift of life; we encounter several issues rooting from numerous distinct things. According to some folks, issues are challenges that God intently give us to test our belief. There are some people who can handle issues really easily. There are also some who finds it really difficult to cope with distinct life scenarios.

Difficulties have numerous roots. Some students locate it really difficult to balance activities and academic subjects. Additionally experience issues when it comes to distribution of requirements. Included pressures from the family and peer are also a large issue. Experts are really much prone to issues due to the technical issues of the things they’re doing. There are some professionals who also handle so much stress from the family and work. Individuals who lack relaxation but carries loads of stresses are anticipated to face bigger issues. when they actually fail to handle it all, it leads to a condition known as depressive disorders.

Depression is currently regarded as as a disease. Tension and complaint are the common reasons why folks suffer from this. However, other elements like lack of nutrition and heredity can also be regarded as. It takes away so numerous things from a person. It makes him drop his high self esteem. in addition , it doesn’t enable a person to be as socially secure as he can. Typically, depressive disorders is being treated through anti-depressant drugs. However, not all folks can normally adapt to drugs. There are some who’re also not permitted to take any type of medicine due to allergy or any other medical ailments. There still other solutions for depressive disorders. Toronto active release therapy is yet another very good choice.

Author: Sharon Dobson

Those with Crohn’s disease know how blissful a period of remission feels, and how they will do anything to avoid activities or actions that might trigger inflammation and a return of unwanted crohn s symptoms.

Almost all of the Crohn s symptoms you might have are due to this inflammation. if that can be avoided, you may see a reduction in the number of flare-ups that you have to endure. Most of this inflammation occurs within in the intestines, and that might lead you to believe that the foods you eat are triggers. This is only partly true. Though none of these triggers are proven, there are many who believe them to be true. Research is ongoing.

One commonly held belief is that bacteria can cause a flare up of inflammation. There is always bacteria in the digestive system, as many actually aid in digestion of foods and liquids. However, there are some foods that create excess bacteria when they are digested, and milk is one that is said to be a trigger. When people who are lactose intolerant ingest milk the bacteria produced can be overabundant. However, it is thought that it only takes one initial contact with the excess bacteria to cause a reaction, and even if you remove that trigger, reactions can still occur later down the road.

Stress is another trigger that a lot of sufferers regard as one of their biggest problems. There is no scientific evidence to back that up, but many swear it. However, it is not a cause of Crohn’s as many believe, but reducing stress can help reduce flare-ups of Crohn’s symptoms.

There has been research that suggests stress can lower the body’s immunity. You may already know that Crohn’s is an autoimmune disease, so it makes sense that stress could be a trigger. it would also make sense that you should learn to reduce your stresses, and find ways to cope when things are out of hand. Breathing techniques might be great tools for when you are feeling overwhelmed with stress.

There are other items that we ingest that might trigger the inflammation that causes symptoms. Some believe that both antibiotics and NSAIDs are common problems. Antibiotics are often needed to treat infections, and that makes them hard to avoid. NSAIDs like ibuprofen are easier to avoid if they are triggers for you. One of the most agreed upon environmental triggers is smoking. if you smoke, you should quit. You should also avoid being in an enclosed area with someone who smokes so you aren’t getting it second hand.

Though these triggers are not completely accepted, many believe they are big problems. There is also research that indicates there may be a defective gene that can trigger Crohn’s in some people. This has been reported on the Mayo Clinic’s website, and even though the research is on going, they say this is a promising sign in the search for a cure.

If you think your Crohn s symptoms are being triggered by certain things, you should eliminate those items or actions from your life to see if improvements are made to your symptoms.

Article Source: articlesbase.com/health-articles/what-is-triggering-your-crohns-symptoms-129608.html

About the AuthorGrab your free copy of Sharon Dobson’s brand new Crohn’s Disease Newsletter – Overflowing with easy to implement tips helping you overcome Crohn s symptoms.