Tysabri has (so far) stopped the progression of my MS, while previous treatments did nothing for me. I had 1 1/2 years of constant relapses. I’ve had 15 Tysabri infusions and haven’t had much concern about getting PML. I haven’t felt this good in a long time, and my last MRI’s in 11/10 showed no new disease activity. BUT, with the recent information on additional label warnings the FDA is requiring I’m feeling a bit concerned. I intend to talk with my MS doc at my next appointment (6/11) about taking a “drug holiday” after 24 infusions. I’m participating in a clinical trial and was tested for the JC virus (blood test, not LP), I’m fortunate it was negative. Not sure what to do, but have confidence in my doctor and feel we’ll make a good decision as a team after weighing the pros and cons of Tysabri. The FDA statement said the benefits of Tysabri still outweigh the risks. I use an infusion center that is well aware of the risks, follows the TOUCH program requirements and has very compassionate, observant RN’s. I feel like I absolutely have the right team in place to manage the use of Tysabri with me. on second thought, I may have just rambled enough to decide against the drug holiday!my best to all of you that are living with MS, stay positive and don’t let it win!