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	<title>Symptom Advice .com &#187; kidney disease</title>
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		<title>How do you keep your nails looking pretty,nice and clean?</title>
		<link>http://symptomadvice.com/how-do-you-keep-your-nails-looking-prettynice-and-clean/</link>
		<comments>http://symptomadvice.com/how-do-you-keep-your-nails-looking-prettynice-and-clean/#comments</comments>
		<pubDate>Thu, 27 Oct 2011 22:00:56 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[psoriasis symptoms]]></category>
		<category><![CDATA[kidney disease]]></category>
		<category><![CDATA[psoriasis]]></category>

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		<description><![CDATA[Barney Simon &#8211; It means a Healthy Body! Don&#8217;t be surprised on your next doctor&#8217;s visit &#105;&#102; she &#119;&#097;&#110;&#116;&#115; to examine your nails. And it &#104;&#097;&#115; nothing to do with your pretty new nail polish. Your fingernails &#099;&#111;&#110;&#116;&#097;&#105;&#110; a wealth of information about your health. &#116;&#104;&#101; color and texture &#099;&#097;&#110; &#097;&#099;&#116;&#117;&#097;&#108;&#108;&#121; reveal &#105;&#102; &#121;&#111;&#117; &#104;&#097;&#118;&#101; [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="" style="float:left;clear:both;margin:0 15px 15px 0" />
<p> Barney Simon &#8211; It means a Healthy Body! </p>
<p>Don&#8217;t be surprised on your next doctor&#8217;s visit &#105;&#102; she &#119;&#097;&#110;&#116;&#115; to examine your nails. And it &#104;&#097;&#115; nothing to do with your pretty new nail polish. Your fingernails &#099;&#111;&#110;&#116;&#097;&#105;&#110; a wealth of information about your health. &#116;&#104;&#101; color and texture &#099;&#097;&#110; &#097;&#099;&#116;&#117;&#097;&#108;&#108;&#121; reveal &#105;&#102; &#121;&#111;&#117; &#104;&#097;&#118;&#101; any number of illnesses, from hepatitis to heart disease. Here &#097;&#114;&#101; 10 &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101; signs of serious conditions manifested in your fingernails: 1.&nbsp;&nbsp; &nbsp;White nails: Liver diseases, &#115;&#117;&#099;&#104; &#097;&#115; hepatitis 2.&nbsp;&nbsp; &nbsp;Yellowish, thickened, slow-growing nails: Lung diseases, &#115;&#117;&#099;&#104; &#097;&#115; emphysema 3.&nbsp;&nbsp; &nbsp;Yellowish nails with a slight blush at &#116;&#104;&#101; base: Diabetes 4.&nbsp;&nbsp; &nbsp;Half-white, half-pink nails: Kidney disease 5.&nbsp;&nbsp; &nbsp;Red nail beds: Heart disease 6.&nbsp;&nbsp; &nbsp;Pale or white nail beds: Anemia 7.&nbsp;&nbsp; &nbsp;Pitting or rippling of &#116;&#104;&#101; nail surface: Psoriasis or inflammatory arthritis 8.&nbsp;&nbsp; &nbsp;Clubbing, a painless increase in tissue &#097;&#114;&#111;&#117;&#110;&#100; &#116;&#104;&#101; ends of &#116;&#104;&#101; fingers, or inversion of &#116;&#104;&#101; nail: Lung diseases 9.&nbsp;&nbsp; &nbsp;Irregular red lines at &#116;&#104;&#101; base of &#116;&#104;&#101; nail fold: Lupus or connective tissue disease 10.&nbsp;&nbsp; &nbsp;Dark lines beneath &#116;&#104;&#101; nail: MelanomaDo note &#116;&#104;&#097;&#116; changes in &#116;&#104;&#101; nails &#097;&#114;&#101; rarely &#116;&#104;&#101; first symptom of serious diseases. &#105;&#110;&#115;&#116;&#101;&#097;&#100;, you&#8217;ll feel other symptoms before nail abnormalities &#097;&#114;&#101; present. </p></p>
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		<title>Top 6 signs of illness in cats and dogs : Tails Of The City</title>
		<link>http://symptomadvice.com/top-6-signs-of-illness-in-cats-and-dogs-tails-of-the-city/</link>
		<comments>http://symptomadvice.com/top-6-signs-of-illness-in-cats-and-dogs-tails-of-the-city/#comments</comments>
		<pubDate>Thu, 21 Jul 2011 11:17:09 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[dog symptoms]]></category>
		<category><![CDATA[autoimmune disease]]></category>
		<category><![CDATA[halitosis]]></category>
		<category><![CDATA[kidney disease]]></category>
		<category><![CDATA[veterinarian]]></category>

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		<description><![CDATA[As pet owners, we all &#119;&#097;&#110;&#116; &#116;&#111; give &#111;&#117;&#114; furry family members the very best care &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101; &#116;&#111; keep &#116;&#104;&#101;&#109; &#105;&#110; &#111;&#117;&#114; lives for &#097;&#115; long &#097;&#115; &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101;. For this reason, it&#8217;s helpful &#116;&#111; &#098;&#101; familiar with the symptoms &#111;&#102; potential life-threatening pet diseases &#115;&#111; we can catch &#116;&#104;&#101;&#109; &#105;&#110; their earliest stages. Karen &#8220;Doc&#8221; [...]]]></description>
			<content:encoded><![CDATA[<p></p><p>As pet owners, we all &#119;&#097;&#110;&#116; &#116;&#111; give &#111;&#117;&#114; furry family members the very best care &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101; &#116;&#111; keep &#116;&#104;&#101;&#109; &#105;&#110; &#111;&#117;&#114; lives for &#097;&#115; long &#097;&#115; &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101;. For this reason, it&#8217;s helpful &#116;&#111; &#098;&#101; familiar with the symptoms &#111;&#102; potential life-threatening pet diseases &#115;&#111; we can catch &#116;&#104;&#101;&#109; &#105;&#110; their earliest stages.</p>
<p> <img alt="Karen " style="float: left;clear: both;margin-top: 0pt;margin-right: 12px;margin-bottom: 12px;margin-left: 0pt">
<p>Karen &#8220;Doc&#8221; Halligan.</p>
<p>Veterinarian &#097;&#110;&#100; author Karen &#8220;Doc&#8221; Halligan, who &#099;&#117;&#114;&#114;&#101;&#110;&#116;&#108;&#121; serves &#097;&#115; the director &#111;&#102; veterinary services for the Society for the Prevention &#111;&#102; Cruelty &#116;&#111; Animals, Los Angeles (spcaLA), shares the &#115;&#105;&#120; most common signs &#111;&#102; illness &#116;&#111; &#108;&#111;&#111;&#107; &#111;&#117;&#116; for &#105;&#110; dogs &#097;&#110;&#100; cats:</p>
<p> <strong>1. Halitosis</strong> &#8211; Bad breath, &#111;&#114; halitosis, &#105;&#115; a sign &#111;&#102; ill health. Bad breath &#105;&#110; dogs &#097;&#110;&#100; cats &#105;&#115; most commonly a symptom &#111;&#102; dental disorders &#108;&#105;&#107;&#101; periodontal disease, gingivitis, plaque buildup, abscesses, sores, tumors &#097;&#110;&#100; ulcers &#111;&#102; the mouth. But there &#097;&#114;&#101; other diseases that can cause bad breath, including skin disease &#097;&#114;&#111;&#117;&#110;&#100; the mouth, tumors &#111;&#114; foreign objects stuck &#105;&#110; the mouth, &#097;&#115; &#119;&#101;&#108;&#108; &#097;&#115; diabetes, autoimmune disease &#097;&#110;&#100; kidney disease. It &#105;&#115; imperative &#116;&#111; investigate the cause &#111;&#102; &#121;&#111;&#117;&#114; pet&#8217;s halitosis &#114;&#097;&#116;&#104;&#101;&#114; &#116;&#104;&#097;&#110; assuming it&#8217;s natural for &#116;&#104;&#101;&#109; &#116;&#111; have bad breath. &#098;&#101;&#099;&#097;&#117;&#115;&#101; it&#8217;s not. If &#121;&#111;&#117;&#114; pet has halitosis, you &#110;&#101;&#101;&#100; &#116;&#111; take &#116;&#104;&#101;&#109; &#105;&#110; for a dental exam &#114;&#105;&#103;&#104;&#116; &#097;&#119;&#097;&#121;. If the cause &#105;&#115; dental disease, once treated you can prevent the recurrence &#111;&#102; bad breath &#105;&#110; &#121;&#111;&#117;&#114; pet with daily brushing &#097;&#110;&#100; yearly professional dental cleanings.</p>
<p><strong>2. Ear Infections</strong> &#8211; &#115;&#105;&#110;&#099;&#101; dogs &#097;&#110;&#100; cats have &#109;&#117;&#099;&#104; longer ear canals &#116;&#104;&#097;&#110; people do, infections usually &#115;&#116;&#097;&#114;&#116; &#119;&#097;&#121; down at the eardrum &#097;&#110;&#100; work their &#119;&#097;&#121; upward. &#115;&#111; by the time you actually see debris, the infection has most &#108;&#105;&#107;&#101;&#108;&#121; been there a &#119;&#104;&#105;&#108;&#101;. &#116;&#104;&#101;&#121; &#097;&#114;&#101; susceptible &#116;&#111; ear infections &#098;&#101;&#099;&#097;&#117;&#115;&#101; &#111;&#102; their long, L-shaped canals; &#115;&#111;&#109;&#101; dogs have wax-trapping hair lining the canals &#097;&#115; &#119;&#101;&#108;&#108;. &#097;&#110;&#100; dogs that have moisture-sealing earflaps provide the perfect swamp-like environment for bugs &#116;&#111; thrive. Check &#111;&#117;&#116; &#121;&#111;&#117;&#114; pet&#8217;s ears. &#116;&#104;&#101;&#121; &#115;&#104;&#111;&#117;&#108;&#100; have very little odor &#111;&#114; discharge, but a small amount &#111;&#102; wax &#105;&#115; normal. If you see debris, redness, hair loss, crusting &#111;&#114; &#121;&#111;&#117;&#114; pet seems &#116;&#111; &#098;&#101; &#105;&#110; pain &#119;&#104;&#101;&#110; &#105;&#116;&#115; ears &#097;&#114;&#101; touched, it &#099;&#111;&#117;&#108;&#100; &#098;&#101; a sign &#111;&#102; &#097;&#110; ear infection, which means a trip &#116;&#111; the vet for ear medication &#097;&#110;&#100; antibiotics. &#116;&#111; prevent infections, pet owners can learn from their vet &#104;&#111;&#119; &#116;&#111; properly &#097;&#110;&#100; regularly clean their animal&#8217;s ear canals.</p>
<p><strong>3. Vomiting &#097;&#110;&#100; Diarrhea</strong> &#8211; More &#116;&#104;&#097;&#110; 60 percent &#111;&#102; all vet bills &#097;&#110;&#100; vet visits for vomiting &#111;&#114; diarrhea &#097;&#114;&#101; &#100;&#117;&#101; &#116;&#111; illnesses resulting from what a pet ate. This ranges from bones &#116;&#111; burgers, pizza, chocolate, avocados &#097;&#110;&#100; double-doubles. I recommend twice daily feedings &#111;&#102; a high-quality diet &#105;&#110; &#121;&#111;&#117;&#114; pets life stage &#111;&#102; &#101;&#105;&#116;&#104;&#101;&#114; pediatric, adult &#111;&#114; senior. Feed a measured amount &#111;&#102; 50% dry &#097;&#110;&#100; 50% wet food &#097;&#110;&#100; no table scraps. Don&#8217;t vary &#121;&#111;&#117;&#114; pets diet. Stick with &#111;&#110;&#101; brand that &#121;&#111;&#117;&#114; pet likes &#105;&#110; their life stage &#097;&#110;&#100; &#109;&#097;&#107;&#101; &#115;&#117;&#114;&#101; fresh clean water &#105;&#115; &#097;&#108;&#119;&#097;&#121;&#115; available. Cats &#097;&#108;&#115;&#111; suffer from hair balls, which can &#098;&#101; prevented by daily brushing, feeding a highly digestible diet &#097;&#110;&#100; weekly doses &#111;&#102; petroleum jelly &#104;&#101;&#108;&#112; push the hair through the intestinal tract.
<p><strong>4. Skin Irritations</strong> &#8211; The skin &#105;&#115; the largest organ &#111;&#102; the body &#097;&#110;&#100; &#105;&#115; &#097;&#108;&#115;&#111; the &#102;&#105;&#114;&#115;&#116; line &#111;&#102; defense against disease. &#121;&#111;&#117;&#114; cat &#111;&#114; dog&#8217;s coat &#115;&#104;&#111;&#117;&#108;&#100; &#098;&#101; sleek &#097;&#110;&#100; glossy with no fleas &#111;&#114; flea dirt. Flea Allergy Dermatitis, &#111;&#114; FAD, &#105;&#115; the most common allergic pet skin disease. Animals that have flea allergy can develop a severe allergic reaction &#116;&#111; a protein &#105;&#110; the saliva &#111;&#102; certain fleas that &#105;&#115; left &#098;&#101;&#104;&#105;&#110;&#100; from fleabites. This condition &#099;&#097;&#117;&#115;&#101;&#115; severe itching &#097;&#110;&#100; a rash. &#105;&#110; dogs, it leads &#116;&#111; hair loss &#097;&#110;&#100; infection, usually on the rear legs &#111;&#114; at the base &#111;&#102; the tail. Cats get scabs &#097;&#114;&#111;&#117;&#110;&#100; the head, neck &#097;&#110;&#100; body. &#116;&#111; prevent this, use a high quality flea &#097;&#110;&#100; tick product monthly on all pets &#105;&#110; the household.</p>
<p><strong>5. Obesity</strong> &#8211; About 65% &#111;&#102; American adults &#097;&#114;&#101; overweight &#111;&#114; obese, &#097;&#110;&#100; studies show that more &#116;&#104;&#097;&#110; 40% &#111;&#102; dogs &#097;&#110;&#100; cats &#097;&#114;&#101; overweight &#111;&#114; obese too. If you consume more calories &#116;&#104;&#097;&#110; you burn, you&#8217;ll gain weight, &#097;&#110;&#100; this goes for &#111;&#117;&#114; pets &#097;&#115; &#119;&#101;&#108;&#108;. Feed &#116;&#104;&#101;&#109; a balanced, nutritionally complete diet, &#097;&#110;&#100; tailor it &#116;&#111; &#121;&#111;&#117;&#114; pet&#8217;s lifestyle. &#097;&#108;&#119;&#097;&#121;&#115; measure the amount &#111;&#102; food you feed &#121;&#111;&#117;&#114; pets &#097;&#110;&#100; &#110;&#101;&#118;&#101;&#114; feed table scraps &#111;&#102; &#097;&#110;&#121; kind. &#116;&#104;&#101;&#121; add calories &#097;&#110;&#100; will unbalance &#121;&#111;&#117;&#114; pet&#8217;s diet. Give dog &#111;&#114; cat treats sparingly &#097;&#110;&#100; incorporate these extra calories into &#121;&#111;&#117;&#114; pet&#8217;s total daily allotment. Treats &#115;&#104;&#111;&#117;&#108;&#100; account for less &#116;&#104;&#097;&#110; 10% &#111;&#102; total calories.</p>
<p><strong>6. Inappropriate Urination</strong> &#8211; Kidney disease &#105;&#115; common &#105;&#110; older cats, &#097;&#110;&#100; both cats &#097;&#110;&#100; dogs can lose &#117;&#112; &#116;&#111; 75% &#111;&#102; kidney function before clinical signs will develop. Blood work can detect early changes &#105;&#110; kidney enzymes &#097;&#110;&#100; &#097;&#108;&#108;&#111;&#119; management &#111;&#102; this disease before it becomes life-threatening. Symptoms &#105;&#110; dogs &#097;&#110;&#100; cats include increased thirst &#111;&#114; urination, weight loss, listlessness, nausea, dehydration, vomiting, diarrhea, constipation, mouth sores, foul-smelling breath, poor appetite &#097;&#110;&#100; lethargy. Cats may &#097;&#108;&#115;&#111; vocalize &#097;&#110;&#100; urinate outside &#111;&#102; their litter box. About 25% &#111;&#102; cats with chronic kidney disease will develop high blood pressure. It&#8217;s not uncommon for these cats &#097;&#110;&#100; dogs &#116;&#111; have a long history &#111;&#102; excessive water consumption. Treatment &#111;&#102; kidney disease depends on the degree &#111;&#102; damage, but can &#098;&#101; successful. Prevention includes yearly exams for early detection &#097;&#110;&#100; providing plenty &#111;&#102; fresh drinking water.</p>
<p>Posted By: Amelia Glynn (Email, Facebook) | July 13 2011 at 04:19 PM</p></p>
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		<title>The Gift of Life</title>
		<link>http://symptomadvice.com/the-gift-of-life/</link>
		<comments>http://symptomadvice.com/the-gift-of-life/#comments</comments>
		<pubDate>Wed, 01 Jun 2011 10:51:05 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[kidney symptoms]]></category>
		<category><![CDATA[beaver dam]]></category>
		<category><![CDATA[kidney disease]]></category>
		<category><![CDATA[quarts]]></category>
		<category><![CDATA[tanner]]></category>

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		<description><![CDATA[Leader/Jessica TannerIn 2006, Brenda Fowkes was diagnosed with Polycystic Kidney Disease. &#098;&#111;&#116;&#104; her kidneys &#119;&#101;&#114;&#101; removed in November 2010, &#097;&#110;&#100; &#115;&#104;&#101; received the gift of life on April 5, 2011, &#119;&#104;&#101;&#110; &#115;&#104;&#101; received her cadaver kidney. Her husband, Heber has &#098;&#101;&#101;&#110; there &#102;&#111;&#114; her &#097;&#108;&#108; along the way &#097;&#110;&#100; &#116;&#104;&#101;&#121; are closer now than &#101;&#118;&#101;&#114;. [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="tremontonleader.com/wp-content/plugins/max-banner-ads/max-banner-ads-lib/include/impression.php?ids=20" width="1" height="1" border="0">
<p><strong>Leader/Jessica Tanner</strong>In 2006, Brenda Fowkes was diagnosed with Polycystic Kidney Disease. &#098;&#111;&#116;&#104; her kidneys &#119;&#101;&#114;&#101; removed in November 2010, &#097;&#110;&#100; &#115;&#104;&#101; received the gift of life on April 5, 2011, &#119;&#104;&#101;&#110; &#115;&#104;&#101; received her cadaver kidney. Her husband, Heber has &#098;&#101;&#101;&#110; there &#102;&#111;&#114; her &#097;&#108;&#108; along the way &#097;&#110;&#100; &#116;&#104;&#101;&#121; are closer now than &#101;&#118;&#101;&#114;.</p>
<p><strong>Jessica Tanner</strong>Leader Staff Writer</p>
<p>Every day &#097; person’s kidneys process about 200 quarts of blood to sift &#111;&#117;&#116; about &#116;&#119;&#111; quarts of waste products &#097;&#110;&#100; extra water, which becomes urine. &#115;&#111; &#119;&#104;&#097;&#116; &#119;&#111;&#117;&#108;&#100; happen if your kidneys &#119;&#101;&#114;&#101; failing &#111;&#114; &#119;&#101;&#114;&#101; removed? Local Beaver Dam woman, Brenda Fowkes, experienced this &#102;&#105;&#114;&#115;&#116; hand.Polycystic kidney disease &#105;&#115; hereditary &#097;&#110;&#100; several of Brenda’s family members experienced symptoms in their 20s. &#115;&#104;&#101; &#100;&#105;&#100; &#110;&#111;&#116; think &#115;&#104;&#101; had inherited the disease &#117;&#110;&#116;&#105;&#108; &#115;&#104;&#101; &#116;&#111;&#111; started experiencing symptoms &#097;&#116; the age of 46.“I was &#103;&#101;&#116;&#116;&#105;&#110;&#103; tired &#097; lot &#098;&#117;&#116; I figured it was because I was &#103;&#101;&#116;&#116;&#105;&#110;&#103; older &#097;&#110;&#100; &#100;&#105;&#100; &#110;&#111;&#116; think &#109;&#117;&#099;&#104; of it,” &#115;&#104;&#101; &#115;&#097;&#105;&#100;. In 2006, &#119;&#104;&#101;&#110; &#115;&#104;&#101; had her gall bladder removed, &#115;&#104;&#101; found &#111;&#117;&#116; her kidneys &#119;&#101;&#114;&#101; enlarged.“I &#119;&#101;&#110;&#116; downhill &#102;&#097;&#115;&#116;. I was &#097;&#110;&#103;&#114;&#121; &#097;&#110;&#100; depressed &#102;&#111;&#114; &#097; long time, &#097;&#110;&#100; &#119;&#101;&#110;&#116; through the total grieving process,” Brenda &#115;&#097;&#105;&#100;. It was devastating &#102;&#111;&#114; her to &#107;&#110;&#111;&#119; &#115;&#104;&#101; could pass this disease on to her children.&#115;&#104;&#101; added, “For the longest time I was just going through the motions, there was &#110;&#111;&#116;&#104;&#105;&#110;&#103; I could do. It &#105;&#115; &#097; &#119;&#101;&#105;&#114;&#100; disease because &#121;&#111;&#117; wait &#102;&#111;&#114; your kidneys to fail.” Brenda just had to wait &#117;&#110;&#116;&#105;&#108; &#115;&#104;&#101; &#103;&#111;&#116; sick enough &#102;&#111;&#114; dialysis &#097;&#110;&#100; &#102;&#111;&#114; &#119;&#104;&#101;&#110; it &#119;&#111;&#117;&#108;&#100; &#098;&#101; time to remove her kidneys.After grieving &#102;&#111;&#114; &#115;&#111; long, &#115;&#104;&#101; realized &#115;&#104;&#101; &#100;&#105;&#100; &#110;&#111;&#116; &#119;&#097;&#110;&#116; to feel this way &#097;&#110;&#100; &#100;&#101;&#099;&#105;&#100;&#101;&#100; to change her attitude. &#115;&#104;&#101; &#115;&#097;&#105;&#100;, “I &#116;&#104;&#111;&#117;&#103;&#104;&#116;, this &#105;&#115; ridiculous…I &#100;&#101;&#099;&#105;&#100;&#101;&#100; to get glad, I guess &#097;&#110;&#100; I &#103;&#111;&#116; &#111;&#118;&#101;&#114; it.”(For the rest of the story pick up &#097; copy of the paper &#097;&#116; the Leader &#111;&#114; call 435-257-5182 to subscribe.)</p></p>
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		<title>Canine Kidney Disease &#8211; Recognize the Symptoms and Stop It</title>
		<link>http://symptomadvice.com/canine-kidney-disease-recognize-the-symptoms-and-stop-it/</link>
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		<pubDate>Mon, 04 Apr 2011 16:51:18 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[dog symptoms]]></category>
		<category><![CDATA[dogs]]></category>
		<category><![CDATA[kidney disease]]></category>
		<category><![CDATA[renal system]]></category>
		<category><![CDATA[toxin]]></category>
		<category><![CDATA[veterinarian]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/canine-kidney-disease-recognize-the-symptoms-and-stop-it/</guid>
		<description><![CDATA[Kidney disease &#105;&#110; dogs &#099;&#097;&#110; develop steadily, often &#117;&#115;&#105;&#110;&#103; indications &#119;&#104;&#105;&#099;&#104; &#097;&#114;&#101; effortlessly overlooked. Recoiling &#102;&#114;&#111;&#109; &#116;&#104;&#101; number &#111;&#102; causes, kidney disease &#099;&#111;&#117;&#108;&#100; be detected by &#097; simple blood exam that &#116;&#104;&#101; veterinarian &#099;&#097;&#110; apply once &#097; month. Symptoms &#111;&#102; renal system difficulties &#105;&#110; dogs vary depending on &#116;&#104;&#101; type &#111;&#102; difficulty existing, &#115;&#117;&#099;&#104; &#097;&#115; [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/04/1301935878-58.jpg" style="clear:both;clear:both;margin:0 15px 15px 0;width:500px" />
<p>Kidney disease &#105;&#110; dogs &#099;&#097;&#110; develop steadily, often &#117;&#115;&#105;&#110;&#103; indications &#119;&#104;&#105;&#099;&#104; &#097;&#114;&#101; effortlessly overlooked. Recoiling &#102;&#114;&#111;&#109; &#116;&#104;&#101; number &#111;&#102; causes, kidney disease &#099;&#111;&#117;&#108;&#100; be detected by &#097; simple blood exam that &#116;&#104;&#101; veterinarian &#099;&#097;&#110; apply once &#097; month. </p>
<p>Symptoms &#111;&#102; renal system difficulties &#105;&#110; dogs vary depending on &#116;&#104;&#101; type &#111;&#102; difficulty existing, &#115;&#117;&#099;&#104; &#097;&#115; viral infections, poisoning, or &#101;&#118;&#101;&#110; cancer. Preserving &#097; detailed eye &#105;&#110; &#121;&#111;&#117;&#114; puppy is one &#111;&#102; &#116;&#104;&#101; &#098;&#101;&#115;&#116; ways to detect kidney failure, &#098;&#117;&#116; &#110;&#111;&#116;&#104;&#105;&#110;&#103; rates &#097;&#110; actual examination done once &#097; month. &#104;&#101;&#114;&#101; &#097;&#114;&#101; some &#116;&#104;&#105;&#110;&#103;&#115; you need to understand kidney disease &#105;&#110; dogs, and &#116;&#104;&#101; steps you need to &#116;&#097;&#107;&#101; &#102;&#111;&#114; treatment and drugs.</p>
<p>one. Kidney disease &#105;&#110; dogs is &#111;&#102; 2 kinds, acute renal disappointment, and chronic renal disappointment. &#116;&#104;&#101; former stems &#102;&#114;&#111;&#109; ingesting poisonous materials. &#105;&#110; case you &#104;&#097;&#118;&#101; &#097; couple &#111;&#102; toxic components laying around &#121;&#111;&#117;&#114; home comparable to rat toxin or anti-freeze, &#121;&#111;&#117;&#114; dog may &#104;&#097;&#118;&#101; unintentionally consumed &#116;&#104;&#101;&#109;. Persistent renal failure, on &#116;&#104;&#101; other hand, is &#100;&#097;&#110;&#103;&#101;&#114;&#111;&#117;&#115; and tough to determine &#105;&#110; their beginning. Caused by &#097; variety &#111;&#102; underlying complications &#115;&#117;&#099;&#104; &#097;&#115; congenial abnormalities, leptospirosis or &#101;&#118;&#101;&#110; cancer, chronic renal disappointment &#109;&#111;&#115;&#116;&#108;&#121; affects young dogs and old aged &#111;&#110;&#101;&#115;.</p>
<p>2. Kidney disease &#105;&#110; dogs causes &#118;&#097;&#114;&#105;&#111;&#117;&#115; symptoms. &#116;&#104;&#101; very first &#116;&#104;&#105;&#110;&#103; you &#097;&#114;&#101; bound to notice would be &#116;&#104;&#101; dogs frequent sessions &#111;&#102; desire and urination. Because &#111;&#102; &#116;&#104;&#101; kidneys weakness &#105;&#110; digesting fluids, &#116;&#104;&#101; body indicators &#116;&#104;&#101; mental performance to &#117;&#115;&#101; &#109;&#111;&#114;&#101; liquids, leaving &#116;&#104;&#101; dog &#101;&#097;&#103;&#101;&#114; on &#097; regular basis.</p>
<p>3. Renal system acne scarring &#119;&#105;&#108;&#108; give &#116;&#104;&#101; dog &#097; hard and painful time urinating. Excruciating discomfort &#099;&#097;&#110; encourage &#121;&#111;&#117;&#114; dog to vomit pool water he drinks, &#115;&#111; observe cautiously &#102;&#111;&#114; traces &#111;&#102; vomit &#097;&#099;&#114;&#111;&#115;&#115; &#116;&#104;&#101; house.</p>
<p>four. &#105;&#110; case &#110;&#111;&#116; handled early on, &#116;&#104;&#101; problems may start to worsen. &#116;&#104;&#101; dog &#119;&#105;&#108;&#108; start weight reducing her urge &#102;&#111;&#114; food trying to find tired and careful. &#116;&#104;&#101; dog may undergo melancholy and &#098;&#101;&#099;&#111;&#109;&#101; extremely lethargic. Attempt smelling &#116;&#104;&#101; dogs puff &#102;&#111;&#114; traces &#111;&#102; ammonia. &#105;&#116; is there unlucky aspect that &#121;&#111;&#117;&#114; puppy &#104;&#097;&#115; &#098;&#101;&#099;&#111;&#109;&#101; incredibly unwell. You need to talk to &#097; veterinary directly.</p>
<p>5. Indicators &#111;&#102; dog kidney disease change largely. Some puppies monitor their indications early, &#119;&#104;&#105;&#108;&#101; some may look wonderful fine &#117;&#110;&#116;&#105;&#108; &#116;&#104;&#105;&#110;&#103;&#115; start to intensify rapidly. &#116;&#104;&#101; first signal &#111;&#102; &#116;&#104;&#101; symptom &#111;&#117;&#103;&#104;&#116; to be representing you to &#116;&#097;&#107;&#101; &#121;&#111;&#117;&#114; dog to &#116;&#104;&#101; vet. Kidney disease &#105;&#110; dogs is &#116;&#104;&#101; &#115;&#101;&#114;&#105;&#111;&#117;&#115; matter that needs &#116;&#104;&#101; &#105;&#110;&#116;&#101;&#114;&#101;&#115;&#116; &#111;&#102; &#116;&#104;&#101; medical professional. Bring &#097;&#110; urine test along &#119;&#105;&#116;&#104; you &#105;&#110; &#121;&#111;&#117;&#114; go to. Remember &#097;&#115; well to &#110;&#101;&#118;&#101;&#114; deny &#121;&#111;&#117;&#114; dog &#111;&#102; &#116;&#104;&#101; water he needs, whether or &#110;&#111;&#116; he expels &#116;&#104;&#101;&#109; or urinates &#116;&#104;&#101;&#109; indefinitely. &#121;&#111;&#117;&#114; dog is trying to water his weak renal system, &#116;&#104;&#101;&#114;&#101;&#102;&#111;&#114;&#101; water should be &#109;&#097;&#100;&#101; &#097;&#118;&#097;&#105;&#108;&#097;&#098;&#108;&#101;.</p>
<p>Avoidance is &#098;&#101;&#116;&#116;&#101;&#114; &#116;&#104;&#097;&#110; heal. &#105;&#110; chronic kidney failure and renal kidney disappointment, &#116;&#104;&#101; &#100;&#097;&#109;&#097;&#103;&#101; is everlasting. Kidney disease &#105;&#110; dogs does &#110;&#111;&#116; heal, &#098;&#117;&#116; fortunately, by &#117;&#115;&#105;&#110;&#103; &#097; &#112;&#117;&#116; dietary management strategy, &#116;&#104;&#101; dog &#099;&#097;&#110; &#110;&#111;&#110;&#101;&#116;&#104;&#101;&#108;&#101;&#115;&#115; live &#097; &#104;&#097;&#112;&#112;&#121; regular life. Ask &#121;&#111;&#117;&#114; vet &#102;&#111;&#114; diet plans advised &#102;&#111;&#114; puppies who suffer &#102;&#114;&#111;&#109; kidney disease. &#100;&#111; &#110;&#111;&#116; deny &#116;&#104;&#101; dog &#111;&#102; &#116;&#104;&#101; longer and &#109;&#111;&#114;&#101; healthy living.</p>
<p>Discover &#116;&#104;&#101; effective treatment and all-natural remedies &#102;&#111;&#114; canine kidney disease, go to &#111;&#117;&#114; site &#110;&#111;&#119;: Find &#111;&#117;&#116; More</p></p>
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		<title>Kidney Disease questions?? Can the symptoms kidney disease be similar to mono symptoms?</title>
		<link>http://symptomadvice.com/kidney-disease-questions-can-the-symptoms-kidney-disease-be-similar-to-mono-symptoms/</link>
		<comments>http://symptomadvice.com/kidney-disease-questions-can-the-symptoms-kidney-disease-be-similar-to-mono-symptoms/#comments</comments>
		<pubDate>Wed, 02 Mar 2011 15:51:15 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[kidney symptoms]]></category>
		<category><![CDATA[kidney disease]]></category>
		<category><![CDATA[mono symptoms]]></category>
		<category><![CDATA[pregnancy]]></category>

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		<description><![CDATA[Can &#116;&#104;&#101; symptoms kidney disease &#098;&#101; similar &#116;&#111; mono symptoms? Can &#105;&#115; cause &#121;&#111;&#117; &#116;&#111; miss &#097; period? Does it &#104;&#097;&#118;&#101; &#115;&#111;&#109;&#101; &#111;&#102; &#116;&#104;&#101; same symptoms &#111;&#102; pregnancy?]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/03/1299081076-16.jpg" style="float:left;clear:both;margin:0 15px 15px 0" />
<p>Can &#116;&#104;&#101; symptoms kidney disease &#098;&#101; similar &#116;&#111; mono symptoms?<br /> Can &#105;&#115; cause &#121;&#111;&#117; &#116;&#111; miss &#097; period?<br /> Does it &#104;&#097;&#118;&#101; &#115;&#111;&#109;&#101; &#111;&#102; &#116;&#104;&#101; same symptoms &#111;&#102; pregnancy?</p></p>
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		<title>What are the symptoms of kidney disease and what are the thing or ways to prevent it?</title>
		<link>http://symptomadvice.com/what-are-the-symptoms-of-kidney-disease-and-what-are-the-thing-or-ways-to-prevent-it/</link>
		<comments>http://symptomadvice.com/what-are-the-symptoms-of-kidney-disease-and-what-are-the-thing-or-ways-to-prevent-it/#comments</comments>
		<pubDate>Fri, 28 Jan 2011 01:17:11 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[kidney symptoms]]></category>
		<category><![CDATA[abdominal pain]]></category>
		<category><![CDATA[allergic reactions]]></category>
		<category><![CDATA[kidney disease]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/what-are-the-symptoms-of-kidney-disease-and-what-are-the-thing-or-ways-to-prevent-it/</guid>
		<description><![CDATA[It depends &#111;&#110; &#116;&#104;&#101; cause. &#121;&#111;&#117; &#110;&#101;&#101;&#100; to discuss this with &#121;&#111;&#117;&#114; Dr. go to &#097;&#098;&#111;&#117;&#116;.com it has a &#118;&#101;&#114;&#121; extensive explaintion &#097;&#098;&#111;&#117;&#116; it. Mine &#115;&#116;&#097;&#114;&#116;&#101;&#100; to fail &#100;&#117;&#101; to several serve allergic reactions to sulfa medications they were telling &#109;&#101; to &#116;&#097;&#107;&#101;..&#101;&#118;&#101;&#110; &#116;&#104;&#111;&#117;&#103;&#104; they knew I &#119;&#097;&#115; allergic to sulfa..had to stay &#111;&#110; 50 [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/01/1296177431-54.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p>It depends &#111;&#110; &#116;&#104;&#101; cause. &#121;&#111;&#117; &#110;&#101;&#101;&#100; to discuss this with &#121;&#111;&#117;&#114; Dr.</p>
<p>go to &#097;&#098;&#111;&#117;&#116;.com<br /> it has a &#118;&#101;&#114;&#121; extensive explaintion &#097;&#098;&#111;&#117;&#116; it.<br /> Mine &#115;&#116;&#097;&#114;&#116;&#101;&#100; to fail &#100;&#117;&#101; to several serve allergic reactions to sulfa medications they were telling &#109;&#101; to &#116;&#097;&#107;&#101;..&#101;&#118;&#101;&#110; &#116;&#104;&#111;&#117;&#103;&#104; they knew I &#119;&#097;&#115; allergic to sulfa..had to stay &#111;&#110; 50 mgs. every 4 hours &#111;&#102; benadryl &#111;&#114; react &#098;&#097;&#100;&#108;&#121; &#101;&#110;&#111;&#117;&#103;&#104; to &#103;&#111; to &#116;&#104;&#101; ER &#097;&#110;&#100; be &#111;&#110; that &#109;&#117;&#099;&#104; Benadryl &amp; 14 day courses &#111;&#102; Predisone.&#102;&#111;&#117;&#110;&#100; &#109;&#111;&#114;&#101; information &#111;&#110; &#097;&#098;&#111;&#117;&#116;.com,&#116;&#104;&#097;&#110; I could get &#102;&#114;&#111;&#109; my specialist..&#104;&#105;&#115; nurse gave &#109;&#101; &#116;&#104;&#101; site</p>
<p>symptoms &#111;&#102; kidney disease are broad. But whenever &#116;&#104;&#101; kidneys are malfunctioned, they lose &#116;&#104;&#101; filtering function; protein &#119;&#105;&#108;&#108; leak &#111;&#117;&#116;, electrolytes &#119;&#105;&#108;&#108; be &#097;&#108;&#108; mess &#117;&#112;. </p>
<p> a patient with kidney disease &#119;&#105;&#108;&#108; be easily fatique, edema &#111;&#114; swollen &#111;&#102; feet, arms &#097;&#110;&#100; face. &#111;&#116;&#104;&#101;&#114; symptoms &#119;&#105;&#108;&#108; be blood in &#116;&#104;&#101; urine, but &#109;&#111;&#115;&#116; &#111;&#102; &#116;&#104;&#101; time microhematuria &#105;&#115; &#110;&#111;&#116; visible to nake eye, &#111;&#114; abdominal pain.</p>
<p> If &#121;&#111;&#117; suspect &#111;&#102; kidneys disease, 2 easy screening tests: urinalysis &#097;&#110;&#100; a metablic profile including sodium, potasium, chloride, bicarbonate level, phosphate, calcium, BUN, creatinin, glucose, &#097;&#110;&#100; albumin.</p>
<p> good luck</p>
<p>If &#121;&#111;&#117; &#103;&#111; online to &#116;&#104;&#101; National Kidney Foundations website, it &#105;&#115; &#118;&#101;&#114;&#121; helpful &#097;&#110;&#100; informative &#111;&#110; this subject.</p>
<p> Kidney disease &#105;&#115; sometimes difficult to recognize in &#116;&#104;&#101; early stages. They are located &#106;&#117;&#115;&#116; above &#121;&#111;&#117;&#114; hip region &#097;&#110;&#100; &#105;&#102; &#121;&#111;&#117; &#104;&#097;&#118;&#101; discomfort in that area &#121;&#111;&#117; &#110;&#101;&#101;&#100; to be checked &#111;&#117;&#116;. When &#121;&#111;&#117; &#104;&#097;&#118;&#101; progress, &#116;&#104;&#101; symptoms range &#102;&#114;&#111;&#109; dizziness, leg muscle pain &#097;&#110;&#100; weakness, excessive thirst &#097;&#110;&#100; urination, etc.</p>
<p> Many people don&#039;t realize they &#104;&#097;&#118;&#101; this &#097;&#110;&#100; it can progress &#097;&#110;&#100; cause life threatening problems with heart &#097;&#110;&#100; lungs. People with diabetes must be especially careful with their kidneys.</p>
<p> There are blood tests, urine tests, CT scans, &#097;&#110;&#100; ultrasound that can be used to diagnose kidney problems.</p></p>
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		<title>What symptoms are there for any and all kidney problems?</title>
		<link>http://symptomadvice.com/what-symptoms-are-there-for-any-and-all-kidney-problems/</link>
		<comments>http://symptomadvice.com/what-symptoms-are-there-for-any-and-all-kidney-problems/#comments</comments>
		<pubDate>Sat, 22 Jan 2011 02:51:09 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[kidney symptoms]]></category>
		<category><![CDATA[itchy skin]]></category>
		<category><![CDATA[kidney disease]]></category>
		<category><![CDATA[shortness of breath]]></category>
		<category><![CDATA[signs of kidney problems]]></category>

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		<description><![CDATA[KIdney problems what are &#116;&#104;&#101; symptoms? Signs of kidney problems vary. I &#104;&#097;&#100; kidney disease &#097;&#110;&#100; didn&#039;t &#101;&#118;&#101;&#110; &#107;&#110;&#111;&#119; &#105;&#116;. But &#115;&#111;&#109;&#101; of &#116;&#104;&#101; signs are: Back pain, shortness of breath, lethargic, itchy skin, &#110;&#111;&#116; urinating a lot, weakness]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/01/1295664669-71.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p> KIdney problems what are &#116;&#104;&#101; symptoms?</p>
<p>Signs of kidney problems vary. I &#104;&#097;&#100; kidney disease &#097;&#110;&#100; didn&#039;t &#101;&#118;&#101;&#110; &#107;&#110;&#111;&#119; &#105;&#116;.<br /> But &#115;&#111;&#109;&#101; of &#116;&#104;&#101; signs are:<br /> Back pain, shortness of breath, lethargic, itchy skin, &#110;&#111;&#116; urinating a lot, weakness</p></p>
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		<title>What are the symptoms of lyme disease in a dog?</title>
		<link>http://symptomadvice.com/what-are-the-symptoms-of-lyme-disease-in-a-dog/</link>
		<comments>http://symptomadvice.com/what-are-the-symptoms-of-lyme-disease-in-a-dog/#comments</comments>
		<pubDate>Fri, 31 Dec 2010 08:34:14 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[lyme symptoms]]></category>
		<category><![CDATA[antibody test]]></category>
		<category><![CDATA[blood tests]]></category>
		<category><![CDATA[burgdorferi]]></category>
		<category><![CDATA[domestic animals]]></category>
		<category><![CDATA[heart problems]]></category>
		<category><![CDATA[kidney disease]]></category>

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		<description><![CDATA[The symptoms &#111;&#102; Lyme disease &#105;&#110; dogs differ from &#116;&#104;&#111;&#115;&#101; &#105;&#110; people, &#097;&#110;&#100; &#117;&#115;&#117;&#097;&#108;&#108;&#121; occur &#109;&#117;&#099;&#104; later after the tick bite. Clinical illness &#105;&#110; dogs &#117;&#115;&#117;&#097;&#108;&#108;&#121; occurs 2 &#116;&#111; 5 months after a bite from an infected tick. Cats &#099;&#097;&#110; develop Lyme disease, but &#105;&#116; occurs rarely &#105;&#110; &#116;&#104;&#101;&#109;, &#101;&#118;&#101;&#110; &#105;&#110; endemic areas. &#111;&#116;&#104;&#101;&#114; domestic [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2010/12/1293784454-45.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p>The symptoms &#111;&#102; Lyme disease &#105;&#110; dogs differ from &#116;&#104;&#111;&#115;&#101; &#105;&#110; people, &#097;&#110;&#100; &#117;&#115;&#117;&#097;&#108;&#108;&#121; occur &#109;&#117;&#099;&#104; later after the tick bite. Clinical illness &#105;&#110; dogs &#117;&#115;&#117;&#097;&#108;&#108;&#121; occurs 2 &#116;&#111; 5 months after a bite from an infected tick. Cats &#099;&#097;&#110; develop Lyme disease, but &#105;&#116; occurs rarely &#105;&#110; &#116;&#104;&#101;&#109;, &#101;&#118;&#101;&#110; &#105;&#110; endemic areas. &#111;&#116;&#104;&#101;&#114; domestic animals such &#097;&#115; horses have contracted Lyme disease, but &#105;&#116; does not appear &#116;&#111; be a significant problem. Dogs &#115;&#104;&#111;&#119; several &#100;&#105;&#102;&#102;&#101;&#114;&#101;&#110;&#116; forms &#111;&#102; the disease, but by far, the most common symptoms are a fever &#111;&#102; between 103 &#097;&#110;&#100; 105°, lameness, swelling &#105;&#110; the joints, swollen lymph nodes, lethargy, &#097;&#110;&#100; loss &#111;&#102; appetite.</p>
<p> Although not common, some dogs have developed severe progressive kidney disease &#097;&#115; sequelae &#116;&#111; Lyme disease. &#116;&#104;&#105;&#115; severe kidney failure &#105;&#115; difficult &#116;&#111; treat &#097;&#110;&#100; &#109;&#097;&#121; result &#105;&#110; death &#111;&#102; the dog. &#105;&#116; &#105;&#115; recommended &#116;&#104;&#097;&#116; a dog &#119;&#105;&#116;&#104; a positive Lyme antibody test have additional blood tests &#097;&#110;&#100; a urinalysis &#116;&#111; assess kidney function. Some dogs &#109;&#097;&#121; &#097;&#108;&#115;&#111; develop heart problems or nervous &#115;&#121;&#115;&#116;&#101;&#109; disease after being infected &#119;&#105;&#116;&#104; B. burgdorferi.</p>
<p> Dogs do not develop the typical rash or the circular area &#111;&#102; redness &#097;&#114;&#111;&#117;&#110;&#100; the bite (erythema migrans) &#119;&#104;&#105;&#099;&#104; &#105;&#115; seen &#105;&#110; people.</p>
<p>- Lameness &#105;&#110; legs<br />- Loss &#111;&#102; appetite<br />- Swelling &#105;&#110; leg<br />- Fever<br />- Dehydration<br />- Lameness<br />- Swollen lymph nodes<br />- Joint disease<br />- Kidney disease</p></p>
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		<title>New approach may help dialysis patients fight anemia</title>
		<link>http://symptomadvice.com/new-approach-may-help-dialysis-patients-fight-anemia/</link>
		<comments>http://symptomadvice.com/new-approach-may-help-dialysis-patients-fight-anemia/#comments</comments>
		<pubDate>Mon, 13 Dec 2010 11:34:13 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[kidney symptoms]]></category>
		<category><![CDATA[cancer]]></category>
		<category><![CDATA[dialysis patients]]></category>
		<category><![CDATA[epo]]></category>
		<category><![CDATA[erlangen germany]]></category>
		<category><![CDATA[kidney disease]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/new-approach-may-help-dialysis-patients-fight-anemia/</guid>
		<description><![CDATA[Anemia is a major problem in patients with kidney disease. &#105;&#116; is caused by &#108;&#111;&#119; production &#111;&#102; EPO, &#119;&#104;&#105;&#099;&#104; has &#098;&#101;&#101;&#110; assumed to result from damage to &#116;&#104;&#101; kidney cells &#116;&#104;&#097;&#116; produce EPO. &#8220;Our study clearly shows &#116;&#104;&#097;&#116; &#116;&#104;&#105;&#115; &#109;&#097;&#121; &#110;&#111;&#116; be &#116;&#104;&#101; case, &#097;&#110;&#100; &#116;&#104;&#097;&#116; &#116;&#104;&#101; kidneys &#111;&#102; patients on dialysis retain significant ability [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2010/12/1292240053-31.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p>Anemia is a major problem in patients with kidney disease. &#105;&#116; is caused by &#108;&#111;&#119; production &#111;&#102; EPO, &#119;&#104;&#105;&#099;&#104; has &#098;&#101;&#101;&#110; assumed to result from damage to &#116;&#104;&#101; kidney cells &#116;&#104;&#097;&#116; produce EPO. &#8220;Our study clearly shows &#116;&#104;&#097;&#116; &#116;&#104;&#105;&#115; &#109;&#097;&#121; &#110;&#111;&#116; be &#116;&#104;&#101; case, &#097;&#110;&#100; &#116;&#104;&#097;&#116; &#116;&#104;&#101; kidneys &#111;&#102; patients on dialysis retain significant ability to produce erythropoietin,&#8221; comments Wanja M. Bernhardt, MD (Department &#111;&#102; Nephrology, University hospital Erlangen, Germany). &#8220;Renal anemia seems to result from disturbed regulation &#114;&#097;&#116;&#104;&#101;&#114; &#116;&#104;&#097;&#110; lost production capacity &#111;&#102; &#116;&#104;&#101; hormone.&#8221;</p>
<p>The study evaluated &#097;&#110; experimental drug called FG-2216. FG-2216 is a prolyl-hydroxylase inhibitor &#116;&#104;&#097;&#116; stabilizes hypoxia-inducible transcription factor (HIF)&#8212;&#116;&#104;&#101; &#8220;master switch&#8221; &#116;&#104;&#097;&#116; normally tells &#116;&#104;&#101; body to produce EPO in response to &#108;&#111;&#119; oxygen levels. EPO stimulates production &#111;&#102; oxygen-carrying red blood cells.</p>
<p>Treatment with FG-2216 significantly increased EPO production in dialysis patients, as &#119;&#101;&#108;&#108; as in healthy people with normal kidneys. &#116;&#104;&#101; greatest increase in EPO production occurred in dialysis patients whose kidneys &#119;&#101;&#114;&#101; still present, &#098;&#117;&#116; &#110;&#111; longer functioning.</p>
<p>FG-2216 also stimulated EPO production in dialysis patients who &#104;&#097;&#100; &#110;&#111; kidneys. (Their kidneys &#104;&#097;&#100; &#098;&#101;&#101;&#110; removed &#097;&#116; surgery for cancer &#111;&#114; other diseases.) &#116;&#104;&#101; increase in EPO production in patients without kidneys &#119;&#097;&#115; almost as high as in people with normally functioning kidneys. In &#116;&#104;&#101; patients without kidneys, FG-2216 apparently stimulated production &#111;&#102; EPO by &#116;&#104;&#101; liver.</p>
<p>Take-home message: &#116;&#104;&#101; results &#113;&#117;&#101;&#115;&#116;&#105;&#111;&#110; &#116;&#104;&#101; conventional wisdom &#116;&#104;&#097;&#116; dialysis-related anemia occurs &#098;&#101;&#099;&#097;&#117;&#115;&#101; patients with advanced kidney disease can &#110;&#111; longer make &#116;&#104;&#101;&#105;&#114; &#111;&#119;&#110; EPO. &#8220;Our results confirm &#116;&#104;&#097;&#116; both &#116;&#104;&#101; liver &#097;&#110;&#100; &#116;&#104;&#101; kidneys retain a significant production capacity for erythropoietin in end-stage renal disease patients,&#8221; &#115;&#097;&#121;&#115; Bernhardt.</p>
<p>Currently, patients with dialysis-related anemia receive EPO replacement therapy with drugs called erythropoiesis-stimulating agents (ESAs). &#100;&#101;&#115;&#112;&#105;&#116;&#101; almost &#116;&#119;&#111; decades &#111;&#102; use, there remains &#097;&#110; ongoing controversy related to &#116;&#104;&#101; safety, appropriate clinical use, &#097;&#110;&#100; in particular high costs &#111;&#102; ESAs. If &#116;&#104;&#101; &#110;&#101;&#119; results &#097;&#114;&#101; borne out by future studies, &#116;&#104;&#101;&#110; &#117;&#115;&#105;&#110;&#103; prolyl-hydroxylase inhibitor such as FG-2216 to help &#116;&#104;&#101; body make its &#111;&#119;&#110; EPO might provide a &#110;&#101;&#119; alternative to ESAs.</p>
<p>The preliminary study evaluated only &#116;&#104;&#101; response to a single dose &#111;&#102; FG-2216. &#097;&#108;&#116;&#104;&#111;&#117;&#103;&#104; there &#119;&#101;&#114;&#101; &#110;&#111; adverse effects, &#116;&#104;&#101; results &#097;&#110;&#100; long-term safety &#111;&#102; activation &#111;&#102; HIF by prolyl-hydroxylase inhibitors remain unclear. &#102;&#117;&#114;&#116;&#104;&#101;&#114; study will also be needed to find out &#119;&#104;&#121; HIF is apparently &#110;&#111;&#116; stabilized in response to decreased oxygen concentrations in patients with kidney disease &#098;&#117;&#116; responds to treatment with prolyl-hydroxylase inhibitors.</p></p>
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