If you have allergies, there are plenty of medications to choose from. but you may not want to take drugs that make you feel listless or wired. or perhaps you’re tired of using nasal sprays for allergy treatment. can allergy supplements offer an alternative with fewer side effects?

Maybe, experts say. “Finding a good supplement for allergies can be a challenge,” says David Rakel, MD, founder and director of the University of Wisconsin Integrative Medicine Program. “Honestly, the pharmaceuticals often work a little better. but there are some out there that can help.”

Other experts agree. David C. Leopold MD, director of Integrative Medical Education at the Scripps Center for Integrative Medicine in San Diego, says some people are able to manage their allergies with natural allergy remedies alone, while others use them as a complement to drugs.

Surveys show that almost half of all people with allergies try a natural allergy remedy. but you need to be careful. Depending on the type of allergy you have, some could actually trigger an allergic reaction.

What Natural Allergy Remedies Work?

Allergies are caused by the immune system’s overreaction to a harmless substance, such as animal dander or pollen. like allergy medication, some supplements can help by blocking the chemical reactions that result in allergy symptoms.

Most natural allergy supplements come in capsules, tablets, or liquids, and are available in drugstores or health food stores. A few may be more difficult to find. If you’re in an urban area, you might try a naturopathic physician, an herbalist, or other expert in integrative health. Otherwise, your best bet may be stores on the Internet.

Here’s the rundown.

• Butterbur. “Butterbur is the Singulair of the herbal world,” says Rakel. “I think of all the allergy supplements, it has the best evidence behind it.” the herb appears to work as a leukotriene inhibitor, which blocks some chemicals that trigger swelling in the nasal passages.

Some research shows that extracts of butterbur root are just as effective at relieving nasal symptoms as prescription drugs like Zyrtec and Allegra. Butterbur has the advantage of not causing sleepiness, a common side effect of antihistamines, even some so-called “non-sedating antihistamines.” “For someone who is driving a car or flying a plane and really needs to avoid the sedative effects of an allergy medication, butterbur is a good alternative,” Rakel says.

You should not eat raw, unprocessed butterbur root, which is dangerous. Look for brands of specialized butterbur supplements that are labeled UPA-free; a certain percentage or milligrams of the helpful compound petasin may also be mentioned. keep in mind that experts aren’t sure about the safety of using any butterbur supplements in the long term.

• Quercetin. Found in wine and many fruits and vegetables, quercetin may work as a mast cell stabilizer. it helps block the release of histamine that causes inflammation. “Quercetin is sort of the herbal equivalent to cromolyn sodium [in the over-the-counter spray NasalCrom],” Rakel tells WebMD. “The evidence is promising.”
  
  “I think quercetin is pretty effective and well tolerated,” says Leopold. “It seems to work well for prevention.” however, while lab tests of quercetin are intriguing, we don’t yet have good research for how well it works as a treatment in people. Some experts doubt that enough quercetin is absorbed during digestion to have much of an effect.
• Stinging Nettle. often used as an allergy treatment, this botanical contains carotene, vitamin K, and quercetin. There’s some evidence that using stinging nettle after the first sign of allergic symptoms can help a bit. Be sure to choose extracts of stinging nettle (Urtica dioica) leaf, not the root, which is used to treat prostate troubles. despite its common use, however, there’s not much research backing up stinging nettle’s effectiveness as an allergy remedy.
• Bromelain. Some studies have found that bromelain is helpful in reducing nasal swelling and thinning mucus, making it easier for people to breathe. it may be particularly useful when added to drug treatment for sinus infections.
• Phleum pratense. A few studies have found that a sublingual tablet made from pollen extracts from Phleum Phleum pratense can reduce some pollen allergy symptoms, such as eye irritation, in people with asthma, as well as help decrease symptoms in people suffering from hay fever. it also allowed people to reduce the dose of their allergy medicine.
• Tinospora cordifolia. Based on one research study, there’s some indication that Tinospora cordifolia, an herbal tablet from India, can reduce allergy symptoms such as sneezing, itching, and nasal discharge. again, the evidence is only preliminary and its long-term safety is unclear. Though it appeared safe during the 8-week research study, more research needs to be done.
• Combination allergy supplements. A number of natural allergy remedies contain a blend of botanicals. Leopold singles out Sinupret, a combination of European elderflower, sorrel, cowslip, verbena, and gentian root. “It’s seems to be effective and well tolerated,” he tells WebMD, “especially for conditions like chronic sinusitis, which can result from allergies.” It’s been long used in Europe, and there’s some evidence that it helps treat the symptoms of bronchitis and acute sinusitis.
• Other allergy supplements. People use many other supplements to treat allergies, including echinacea, grape seed extract, pycnogenol (pine bark extract), vitamin C, EPA, honey, cat’s claw, albizzia (Albizzia lebbeck), baical skullcup (Scutellaria baicalensis),goldenseal, and spirulina. however, research hasn’t found good evidence that they help. “These supplements might have other benefits,” says Rakel. “But if you’re trying to treat allergies, go with something else.”
  
  Be particularly wary of bitter orange (also called Citrus aurantium), which is sometimes sold as a decongestant. it has compounds similar to those in ephedra and, as a result, may have serious side effects. they include an increased risk of high blood pressure, heart problems, and stroke. 

What about supplements for other types of allergies, such as skin reactions or food allergies? Unfortunately, researchers haven’t found much evidence for supplements that can help. Rakel says that while there’s some interesting preliminary evidence about the effects of probiotics on food allergies, more research is needed.