There’s more than joint pain to watch out for.

Painful, swollen joints are a hallmark of rheumatoid arthritis. but for people with RA, it’s not the only thing to watch out for.

A result of the body’s immune system attacking its own tissues, rheumatoid arthritis requires more than just managing the pain. Other symptoms that might even seem unrelated to the condition may pose a threat.

“This is a disease process, not just something that happens in the joints,” rheumatologist Joan Bathon, MD, tells WebMD. “It can be in all your tissues, causing problems wherever inflammation occurs,” says Bathon, who is chief of the rheumatology department at New York-Presbyterian Hospital/Columbia University Medical Center.

People with more severe rheumatoid arthritis are more likely to have other complications. but it can also happen in milder cases.

Here are the top 10 symptoms rheumatoid arthritis patients should never ignore.

1. Shortness of breath or chest pain

Because rheumatoid arthritis can affect the blood vessels and muscle of the heart, people with the condition are at a greater risk for heart attacks and heart failure.

“Chest pains or shortness of breath are big red flags,” says rheumatologist Brian Mandell, MD, PhD, of Cleveland Clinic’s Arthritis and Musculoskeletal Center.

If you’re getting winded easily, you could also have a lung infection. Or you could have some form of interstitial lung disease, which causes lungs to become inflamed and scarred, Mandell says. Fluid might also be surrounding the lungs, which would require drugs and drainage to treat.

Seek medical attention immediately if you’re having these problems, even if you’ve never had heart or lung issues before.

2. Numbness or tingling

Rheumatoid arthritis can cause connective tissues in the hand or foot to become inflamed and push up against a nerve causing numbness and tingling. As a result, you might experience weakness or clumsiness, or even nerve damage.

This type of swelling can happen in tissues throughout the body. but it most commonly occurs around the wrist area, causing carpal tunnel syndrome, Mandell says.

If you experience numbness or tingling, you need to be evaluated by your rheumatologist or another health care provider as soon as possible to determine the cause.

3. Inability to move or raise your hand or foot

Compared to numbness or tingling, suddenly not being able to raise or move a hand or foot is a much more severe complication to result from rheumatoid arthritis. 

It’s also a much more rare occurrence, involving damage to nerves that are connected to muscles.

“It’s like having a heart attack for the nerves,” Bathon tells WebMD.

Seek emergency treatment for this symptom. Bathon says not doing so could lead to permanent paralysis.