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	<title>Symptom Advice .com &#187; nyse</title>
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	<link>http://symptomadvice.com</link>
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		<title>linkedFA Announces Strategic Data Integration Relationship with Thomson Reuters Corporation (TRI)</title>
		<link>http://symptomadvice.com/linkedfa-announces-strategic-data-integration-relationship-with-thomson-reuters-corporation-tri/</link>
		<comments>http://symptomadvice.com/linkedfa-announces-strategic-data-integration-relationship-with-thomson-reuters-corporation-tri/#comments</comments>
		<pubDate>Sun, 03 Jul 2011 23:17:18 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[throat symptoms]]></category>
		<category><![CDATA[financial content]]></category>
		<category><![CDATA[nyse]]></category>
		<category><![CDATA[time members]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/linkedfa-announces-strategic-data-integration-relationship-with-thomson-reuters-corporation-tri/</guid>
		<description><![CDATA[Jun. 1, 2011 (Business Wire) &#8212; linkedFA, the &#102;&#105;&#114;&#115;&#116; social networking web site &#116;&#104;&#097;&#116; enables financial professionals &#116;&#111; leverage social media compliantly by addressing industry rules and regulations, announces &#097; strategic content relationship with Thomson Reuters Corporation (NYSE: TRI ). &#112;&#101;&#114; the agreement, LinkedFA (linkedFA.com) &#119;&#105;&#108;&#108; offer Thomson Reuters&#x2019; premium financial news and analysis content [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/07/1309735038-66.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p>Jun. 1, 2011 (Business Wire) &#8212; linkedFA, the &#102;&#105;&#114;&#115;&#116; social networking web site &#116;&#104;&#097;&#116; enables financial professionals &#116;&#111; leverage social media compliantly by addressing industry rules and regulations, announces &#097; strategic content relationship with Thomson Reuters Corporation (NYSE: TRI ). &#112;&#101;&#114; the agreement, LinkedFA (linkedFA.com) &#119;&#105;&#108;&#108; offer Thomson Reuters&#x2019; premium financial news and analysis content via linkedFA&#x2019;s social media network. The relationship between Thomson Reuters and linkedFA embodies &#097; powerful trend in social media, giving financial professionals access &#116;&#111; the &#098;&#101;&#115;&#116; tools and information &#102;&#111;&#114; their industry in &#097; collaborative social media platform. &#116;&#104;&#105;&#115; information &#105;&#115; &#097;&#118;&#097;&#105;&#108;&#097;&#098;&#108;&#101; &#116;&#111; share &#119;&#105;&#116;&#104;&#105;&#110; their networks. </p>
<p> linkedFA &#119;&#105;&#108;&#108; integrate Thomson Reuters&#x2019; content as &#097; premium service, enabling financial professionals &#116;&#111; easily &#102;&#105;&#110;&#100; and share industry news, market data, market analysis, and more &#119;&#105;&#116;&#104;&#105;&#110; their network via best-in-breed social media tools. &#116;&#104;&#105;&#115; integration &#119;&#105;&#108;&#108; mark &#110;&#111;&#116; &#111;&#110;&#108;&#121; the &#108;&#097;&#114;&#103;&#101;&#115;&#116; foray &#111;&#102; premium financial content offered via social media, &#098;&#117;&#116; &#097;&#108;&#115;&#111; the &#102;&#105;&#114;&#115;&#116; time members can digitally communicate and collaborate &#111;&#110; the content all from one location. </p>
<p> linkedFA CEO, Jason Bishara states: &#x201c;We are excited &#116;&#111; offer Thomson Reuters&#x2019; financial data and content &#119;&#105;&#116;&#104;&#105;&#110; linkedFA. &#111;&#110;&#099;&#101; released, members &#119;&#105;&#108;&#108; &#104;&#097;&#118;&#101; access &#116;&#111; industry-leading financial content and analysis with the ability &#116;&#111; compliantly share &#116;&#104;&#105;&#115; content with their networks &#111;&#110; linkedFA, Twitter, Facebook and LinkedIn simultaneously. &#116;&#104;&#105;&#115; relationship &#119;&#105;&#108;&#108; prove &#116;&#111; &#098;&#101; &#097;&#110; exceptionally powerful tool &#102;&#111;&#114; independent advisors and investors &#119;&#104;&#111; previously &#099;&#111;&#117;&#108;&#100; &#110;&#111;&#116; gain access &#116;&#111; Thomson Reuters&#x2019; content. &#116;&#104;&#105;&#115; &#105;&#115; &#106;&#117;&#115;&#116; &#111;&#117;&#114; &#102;&#105;&#114;&#115;&#116; step in the direction &#111;&#102; integrating content, tools and resources &#116;&#111; bring additional &#118;&#097;&#108;&#117;&#101; &#116;&#111; &#111;&#117;&#114; members.&#x201d; </p>
</p>
<p> &#102;&#111;&#114; linkedFADowney McKay MarketingHelen Downey/Michelle McKay, + </p></p>
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		<title>Sanofi receives FDA license approval for new Influenza vaccine</title>
		<link>http://symptomadvice.com/sanofi-receives-fda-license-approval-for-new-influenza-vaccine/</link>
		<comments>http://symptomadvice.com/sanofi-receives-fda-license-approval-for-new-influenza-vaccine/#comments</comments>
		<pubDate>Wed, 01 Jun 2011 15:34:20 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[influenza symptoms]]></category>
		<category><![CDATA[chronic disease]]></category>
		<category><![CDATA[fall winter]]></category>
		<category><![CDATA[fluzone]]></category>
		<category><![CDATA[nyse]]></category>
		<category><![CDATA[vaccination]]></category>
		<category><![CDATA[virus vaccine]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/sanofi-receives-fda-license-approval-for-new-influenza-vaccine/</guid>
		<description><![CDATA[10th &#109;&#097;&#121; 2011, 11:21 &#097;&#109; &#098;&#121; Olivia D&#039;Orazio Sanofi-Aventis (EPA:SAN) (NYSE:SNY) &#115;&#097;&#105;&#100; Tuesday &#116;&#104;&#097;&#116; its vaccine division, Sanofi Pasteur, &#104;&#097;&#115; received a licensing approval &#102;&#114;&#111;&#109; the US FDA &#102;&#111;&#114; its new flu virus vaccine &#116;&#104;&#097;&#116; &#105;&#115; injected with a short, &#116;&#104;&#105;&#110; needle &#105;&#110; through the mid-level layer of the skin, &#105;&#110;&#115;&#116;&#101;&#097;&#100; of the muscle, of [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/06/1306942461-14.jpg" style="clear:both;clear:both;margin:0 15px 15px 0;width:500px" />10th &#109;&#097;&#121; 2011, 11:21 &#097;&#109; &#098;&#121; Olivia D&#039;Orazio
<p>Sanofi-Aventis (EPA:SAN) (NYSE:SNY) &#115;&#097;&#105;&#100; Tuesday &#116;&#104;&#097;&#116; its vaccine division, Sanofi Pasteur, &#104;&#097;&#115; received a licensing approval &#102;&#114;&#111;&#109; the US FDA &#102;&#111;&#114; its new flu virus vaccine &#116;&#104;&#097;&#116; &#105;&#115; injected with a short, &#116;&#104;&#105;&#110; needle &#105;&#110; through the mid-level layer of the skin, &#105;&#110;&#115;&#116;&#101;&#097;&#100; of the muscle, of those &#098;&#101;&#105;&#110;&#103; vaccinated.</p>
<p>The vaccine, Fluzone Intradermal, &#119;&#105;&#108;&#108; &#098;&#101; &#117;&#115;&#101;&#100; &#102;&#111;&#114; immunization &#097;&#103;&#097;&#105;&#110;&#115;&#116; the influenza virus &#105;&#110; adults aged 18 to 64, &#097;&#110;&#100; represents the first flu vaccine licensed &#105;&#110; the US &#116;&#104;&#097;&#116; uses a small needle &#102;&#111;&#114; a skin injection.</p>
<p>&#8220;The microinjection delivery &#115;&#121;&#115;&#116;&#101;&#109; utilized &#105;&#110; Fluzone Intradermal vaccine &#112;&#114;&#111;&#118;&#105;&#100;&#101;&#115; reliable &#097;&#110;&#100; easy delivery of the vaccine &#105;&#110;&#116;&#111; the dermal layer of the skin, &#097;&#110; attractive site &#102;&#111;&#114; immunization,&#8221; &#115;&#097;&#105;&#100; president &#097;&#110;&#100; CEO of Sanofi Pasteur, Olivier Charmeil.</p>
<p>The influenza virus tends to become prevalent &#100;&#117;&#114;&#105;&#110;&#103; the fall-winter season, with widespread outbreaks &#097;&#099;&#114;&#111;&#115;&#115; the globe. Symptoms include fever, cough &#097;&#110;&#100; general malaise. Complications, such &#097;&#115; pneumonia, &#099;&#097;&#110; occur, especially &#105;&#110; older adults or &#105;&#110; people who suffer &#102;&#114;&#111;&#109; a chronic disease.</p>
<p>Vaccination, usually &#098;&#121; a needle injection &#105;&#110;&#116;&#111; the muscle, often protects &#097;&#103;&#097;&#105;&#110;&#115;&#116; the virus. A typical needle measures &#097;&#098;&#111;&#117;&#116; 1.5 inches &#105;&#110; length, &#119;&#104;&#101;&#114;&#101;&#097;&#115; the Fluzone Intradermal vaccine &#105;&#115; administered &#105;&#110;&#116;&#111; the dermal layer of the skin, with a needle &#116;&#104;&#097;&#116; &#105;&#115; 0.06 inches long.</p>
<p>This method of vaccine administration, called microinjection, &#105;&#115; &#108;&#101;&#115;&#115; intrusive &#097;&#110;&#100; &#105;&#115; easier to administer. The Fluzone Intradermal vaccine includes a pre-filled syringe &#116;&#104;&#097;&#116; deposits influenza antibodies &#105;&#110; the mid-level of the skin, &#097;&#110; area &#116;&#104;&#097;&#116; &#099;&#111;&#110;&#116;&#097;&#105;&#110;&#115; high levels of dendritic cells, which &#097;&#114;&#101; strongly involved &#105;&#110; fighting &#111;&#102;&#102; &#097;&#110; infection.</p>
<p>Sanofi Pasteur &#104;&#097;&#115; previously licensed intradermal microinjections &#105;&#110; &#111;&#118;&#101;&#114; &#102;&#111;&#114;&#116;&#121; countries, including Canada, Europe &#097;&#110;&#100; Australia, marketed &#097;&#115; Intanza or IDflu.</p>
<p>Fluzone Intradermal &#105;&#115; expected to &#098;&#101; available to US healthcare providers &#102;&#111;&#114; the 2011 &#8211; 2012 flu season.</p></p>
]]></content:encoded>
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		<title>LinkedIn Reaches 100 Million Members, IPO Imminent</title>
		<link>http://symptomadvice.com/linkedin-reaches-100-million-members-ipo-imminent/</link>
		<comments>http://symptomadvice.com/linkedin-reaches-100-million-members-ipo-imminent/#comments</comments>
		<pubDate>Sat, 16 Apr 2011 05:51:16 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[parkinson s symptoms]]></category>
		<category><![CDATA[bank of america]]></category>
		<category><![CDATA[j p morgan]]></category>
		<category><![CDATA[market news]]></category>
		<category><![CDATA[nyse]]></category>
		<category><![CDATA[video content]]></category>

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		<description><![CDATA[LinkedIn, &#116;&#104;&#101; social-networking website &#102;&#111;&#114; professionals, said &#105;&#116; reached 100 million members Tuesday, &#097;&#115; &#105;&#116; gears &#117;&#112; &#102;&#111;&#114; &#105;&#116;&#115; much-anticipated IPO.&#116;&#104;&#101; company filed &#102;&#111;&#114; &#105;&#116;&#115; IPO &#119;&#105;&#116;&#104; &#116;&#104;&#101; SEC on January 27th, &#097;&#110;&#100; &#105;&#116; usually takes &#097;&#098;&#111;&#117;&#116; 2 months &#102;&#111;&#114; &#116;&#104;&#101; SEC to complete &#105;&#116;&#115; review.&#116;&#104;&#101; website was founded in May of 2003, &#097;&#110;&#100; &#104;&#097;&#100; [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/04/1302933076-86.gif" style="clear:both;clear:both;margin:0 15px 15px 0;width:500px" />
<p>LinkedIn, &#116;&#104;&#101; social-networking website &#102;&#111;&#114; professionals, said &#105;&#116; reached 100 million members Tuesday, &#097;&#115; &#105;&#116; gears &#117;&#112; &#102;&#111;&#114; &#105;&#116;&#115; much-anticipated IPO.&#116;&#104;&#101; company filed &#102;&#111;&#114; &#105;&#116;&#115; IPO &#119;&#105;&#116;&#104; &#116;&#104;&#101; SEC on January 27th, &#097;&#110;&#100; &#105;&#116; usually takes &#097;&#098;&#111;&#117;&#116; 2 months &#102;&#111;&#114; &#116;&#104;&#101; SEC to complete &#105;&#116;&#115; review.&#116;&#104;&#101; website was founded in May of 2003, &#097;&#110;&#100; &#104;&#097;&#100; 71.5 million unique visitors in February 2011, &#117;&#112; 55% &#102;&#114;&#111;&#109; February 2010, according to comScore.&#111;&#118;&#101;&#114; &#104;&#097;&#108;&#102; of LinkedIn&#8217;s users, 56 million, &#097;&#114;&#101; based &#111;&#117;&#116;&#115;&#105;&#100;&#101; &#116;&#104;&#101; United States. &#108;&#097;&#115;&#116; year, membership grew 428% in Brazil, 178% in Mexico, 76% in India, &#097;&#110;&#100; 72% in France, highlighting &#105;&#116;&#115; truly global appeal.LinkedIn hired Morgan Stanley (NYSE:MS), Bank of America (NYSE:BAC) &#097;&#110;&#100; J.P. Morgan Chase (NYSE:JPM) to lead &#116;&#104;&#101; offering, according to &#116;&#104;&#101; SEC filing.</p>
<p>&#8220;LinkedIn Reaches 100 Million Members, IPO Imminent&#8221; is categorized &#097;&#115; &#8220;business&#8221;. This video was licensed &#102;&#114;&#111;&#109; Grab Networks. &#102;&#111;&#114; additional video content, click &#116;&#104;&#101; &#8220;video&#8221; tab &#097;&#116; &#116;&#104;&#101; top of this page. </p>
<p>If you &#097;&#114;&#101; a &#110;&#101;&#119; American Banking &#038; Market News reader, &#119;&#101; would &#108;&#105;&#107;&#101; to &#119;&#101;&#108;&#099;&#111;&#109;&#101; you to our website. American Banking &#038; Market News provides daily coverage of analysts’ ratings &#102;&#111;&#114; &#115;&#111;&#109;&#101; of &#116;&#104;&#101; &#108;&#097;&#114;&#103;&#101;&#115;&#116; publicly traded companies in &#116;&#104;&#101; world. &#119;&#101; cover news surrounding large-cap U.S. financial companies, including Citigroup, Bank of America, Wells Fargo &#097;&#110;&#100; JPMorgan Chase &#097;&#110;&#100; discuss &#116;&#104;&#101; fledgling industry of peer to peer lending. American Banking &#038; Market News publishes hundreds of press releases &#112;&#101;&#114; day &#097;&#110;&#100; is &#112;&#097;&#114;&#116; of &#116;&#104;&#101; American Consumer News, LLC network. &#119;&#101; would invite you to consider following our &#8216;AmericanBanking&#8217; account on Twitter &#097;&#110;&#100; subscribing to our RSS Feed. You can always view our latest articles &#097;&#110;&#100; video content &#098;&#121; visiting our home page.</p></p>
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		<title>PR-USA.net &#8211; Abbott Announces Crohn&#8217;s Disease Trial to Explore Benefit of New Therapeutic Monitoring Parameters f</title>
		<link>http://symptomadvice.com/pr-usa-net-abbott-announces-crohns-disease-trial-to-explore-benefit-of-new-therapeutic-monitoring-parameters-f/</link>
		<comments>http://symptomadvice.com/pr-usa-net-abbott-announces-crohns-disease-trial-to-explore-benefit-of-new-therapeutic-monitoring-parameters-f/#comments</comments>
		<pubDate>Sun, 10 Apr 2011 12:34:12 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[herpes symptoms]]></category>
		<category><![CDATA[nyse]]></category>
		<category><![CDATA[term outcomes]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/pr-usa-net-abbott-announces-crohns-disease-trial-to-explore-benefit-of-new-therapeutic-monitoring-parameters-f/</guid>
		<description><![CDATA[Abbott (NYSE: ABT) announced today it enrolled &#116;&#104;&#101; first patient in &#116;&#104;&#101; CALM Study, &#097; clinical trial &#119;&#105;&#116;&#104; HUMIRA(R) (adalimumab), to determine &#105;&#102; tailoring therapy to more stringent measures of disease activity in patients &#119;&#105;&#116;&#104; early moderate to severe Crohn&#8217;s disease &#119;&#105;&#108;&#108; improve mucosal healing. &#116;&#104;&#101; study &#119;&#105;&#108;&#108; assess patients monitored &#119;&#105;&#116;&#104; &#116;&#104;&#111;&#115;&#101; stringent criteria [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/04/1302438852-44.png%3Fw%3D510" style="clear:both;clear:both;margin:0 15px 15px 0" /></p>
<p> Abbott (NYSE: ABT) announced today it enrolled &#116;&#104;&#101; first patient in &#116;&#104;&#101; CALM Study, &#097; clinical trial &#119;&#105;&#116;&#104; HUMIRA(R) (adalimumab), to determine &#105;&#102; tailoring therapy to more stringent measures of disease activity in patients &#119;&#105;&#116;&#104; early moderate to severe Crohn&#8217;s disease &#119;&#105;&#108;&#108; improve mucosal healing. &#116;&#104;&#101; study &#119;&#105;&#108;&#108; assess patients monitored &#119;&#105;&#116;&#104; &#116;&#104;&#111;&#115;&#101; stringent criteria &#111;&#118;&#101;&#114; 56 weeks compared to patients monitored &#119;&#105;&#116;&#104; less stringent &#097;&#110;&#100; more commonly used clinical disease management criteria. &#116;&#104;&#105;&#115; international study &#105;&#115; enrolling now in Austria, Belgium, Canada, Czech Republic, France, Germany, Italy, Netherlands, Spain, Sweden, Switzerland, &#097;&#110;&#100; &#116;&#104;&#101; UK &#119;&#105;&#116;&#104; &#116;&#104;&#101; goal to research &#116;&#104;&#101; response rates of approximately 240 people diagnosed &#119;&#105;&#116;&#104; Crohn&#8217;s disease for less &#116;&#104;&#097;&#110; four years &#119;&#104;&#111; &#104;&#097;&#118;&#101; had &#110;&#111; more &#116;&#104;&#097;&#110; &#111;&#110;&#101; course of corticosteroids &#097;&#110;&#100; &#097;&#114;&#101; naive to immunosuppressive &#097;&#110;&#100; biologic therapy. </p>
<p> &#8220;We know Crohn&#8217;s disease &#099;&#097;&#110; be difficult to treat &#097;&#110;&#100; that early intervention may yield improved long-term outcomes,&#8221; said Professor Jean-Frederic Colombel, head of Gastroenterology, University of Lille, France. &#8220;There &#097;&#114;&#101; &#097; number of objective measures &#098;&#121; &#119;&#104;&#105;&#099;&#104; &#119;&#101; &#099;&#097;&#110; quantify &#097; therapy&#8217;s effect. Assessing &#116;&#104;&#101;&#115;&#101; &#105;&#109;&#112;&#111;&#114;&#116;&#097;&#110;&#116; objective measurement tools may provide valuable information for physicians managing &#116;&#104;&#105;&#115; disease.&#8221; </p>
<p> &#116;&#104;&#101; CALM study &#119;&#105;&#108;&#108; evaluate tight control of disease activity, defined as using stringent criteria based &#111;&#110; &#116;&#104;&#101; Crohn&#8217;s disease activity index (CDAI), high sensitivity C-reactive protein levels, &#116;&#104;&#101; fecal Calprotectin test &#097;&#110;&#100; &#116;&#104;&#101; &#110;&#101;&#101;&#100; for continued corticosteroid &#117;&#115;&#101;, &#118;&#101;&#114;&#115;&#117;&#115; disease management based only &#111;&#110; CDAI &#097;&#110;&#100; corticosteroid &#117;&#115;&#101;. </p>
<p> &#8220;The tight-control approach may offer &#097; benchmark for drug therapies relative to symptomatic treatment,&#8221; said Eugene Sun, M.D., vice president, Global Pharmaceutical Clinical Development, Abbott. &#8220;These &#105;&#109;&#112;&#111;&#114;&#116;&#097;&#110;&#116; measures may provide strides toward understanding &#097;&#110;&#100; defining objective disease management tools for Crohn&#8217;s patients.&#8221; </p>
<p> &#097;&#098;&#111;&#117;&#116; &#116;&#104;&#101; CALM Study </p>
<p> &#116;&#104;&#101; CALM Study, &#097;&#110; Open-Label, Multi-Center, Efficacy &#097;&#110;&#100; Safety Study to Evaluate &#116;&#119;&#111; Treatment Algorithms in Subjects &#119;&#105;&#116;&#104; Moderate to Severe Crohn&#8217;s Disease, &#105;&#115; &#097; 56-week, multicenter, randomized, safety &#097;&#110;&#100; efficacy trial of prednisone, HUMIRA, &#097;&#110;&#100; azathioprine using tight control &#118;&#101;&#114;&#115;&#117;&#115; clinically driven management of Crohn&#8217;s disease to evaluate mucosal healing in subjects &#119;&#105;&#116;&#104; moderately to severely active Crohn&#8217;s disease, &#119;&#104;&#111; &#097;&#114;&#101; naive to immunosuppressive &#097;&#110;&#100; biologic therapy. Males &#097;&#110;&#100; females ages 18 to 75 &#119;&#105;&#108;&#108; be enrolled at approximately 60 international study sites &#097;&#099;&#114;&#111;&#115;&#115; Europe &#097;&#110;&#100; Canada. Eligible patients &#119;&#105;&#108;&#108; &#104;&#097;&#118;&#101; been diagnosed &#119;&#105;&#116;&#104; Crohn&#8217;s disease using imaging technology &#111;&#114; endoscopy not more &#116;&#104;&#097;&#110; four years prior to enrolling. They &#119;&#105;&#108;&#108; &#104;&#097;&#118;&#101; some degree of inflammation measured &#098;&#121; high sensitivity C-reactive protein level &#097;&#110;&#100; fecal Calprotectin test. Additionally, participants &#115;&#104;&#111;&#117;&#108;&#100; not &#104;&#097;&#118;&#101; any previous &#111;&#114; current &#117;&#115;&#101; of biologics for Crohn&#8217;s disease &#097;&#110;&#100; &#115;&#104;&#111;&#117;&#108;&#100; not &#104;&#097;&#118;&#101; &#116;&#097;&#107;&#101;&#110; more &#116;&#104;&#097;&#110; &#111;&#110;&#101; previous course of &#097; corticosteroid. </p>
<p> &#097;&#098;&#111;&#117;&#116; Crohn&#8217;s Disease </p>
<p> Crohn&#8217;s disease &#105;&#115; &#097; serious chronic inflammatory autoimmune disorder of &#116;&#104;&#101; gastrointestinal tract. It &#109;&#111;&#115;&#116; commonly affects &#116;&#104;&#101; end of &#116;&#104;&#101; small intestine &#111;&#114; &#116;&#104;&#101; ileum, however, it may involve any &#112;&#097;&#114;&#116; of &#116;&#104;&#101; gastrointestinal tract. Symptoms &#099;&#097;&#110; range &#102;&#114;&#111;&#109; diarrhea, abdominal pain &#097;&#110;&#100; fever to rectal bleeding. </p>
<p> &#105;&#109;&#112;&#111;&#114;&#116;&#097;&#110;&#116; Treatment Considerations </p>
<p> Globally, prescribing information varies; refer to &#116;&#104;&#101; individual country product &#108;&#097;&#098;&#101;&#108; for complete information. </p>
<p> HUMIRA &#105;&#115; used to reduce &#116;&#104;&#101; signs &#097;&#110;&#100; symptoms of Crohn&#8217;s disease (CD) in adults &#119;&#104;&#111; &#104;&#097;&#118;&#101; not responded well to conventional treatments. </p>
<p> Serious infections, including sepsis, due to bacterial, mycobacterial, invasive fungal, parasitic, &#111;&#114; viral pathogens, rare cases of tuberculosis (TB), &#097;&#110;&#100; &#111;&#116;&#104;&#101;&#114; opportunistic infections, including fatalities, &#104;&#097;&#118;&#101; been reported &#119;&#105;&#116;&#104; &#116;&#104;&#101; &#117;&#115;&#101; of TNF-antagonists, including HUMIRA. &#109;&#097;&#110;&#121; of &#116;&#104;&#101; serious infections &#104;&#097;&#118;&#101; occurred in patients &#111;&#110; concomitant immunosuppressive therapy that, in addition to their underlying disease &#099;&#111;&#117;&#108;&#100; predispose &#116;&#104;&#101;&#109; to infections. Patients must be monitored closely for infections, including tuberculosis, before, during &#097;&#110;&#100; &#097;&#102;&#116;&#101;&#114; treatment &#119;&#105;&#116;&#104; HUMIRA. Treatment &#115;&#104;&#111;&#117;&#108;&#100; not be initiated in patients &#119;&#105;&#116;&#104; active infections &#117;&#110;&#116;&#105;&#108; infections &#097;&#114;&#101; controlled. In patients &#119;&#104;&#111; &#104;&#097;&#118;&#101; been exposed to tuberculosis &#097;&#110;&#100; patients &#119;&#104;&#111; &#104;&#097;&#118;&#101; travelled in areas of high risk of tuberculosis &#111;&#114; endemic mycoses, such as histoplasmosis, coccidioidomycosis, &#111;&#114; blastomycosis, &#116;&#104;&#101; risk &#097;&#110;&#100; benefits of treatment &#119;&#105;&#116;&#104; HUMIRA &#115;&#104;&#111;&#117;&#108;&#100; be considered prior to initiating therapy. HUMIRA &#115;&#104;&#111;&#117;&#108;&#100; not be used &#098;&#121; patients &#119;&#105;&#116;&#104; active TB &#111;&#114; &#111;&#116;&#104;&#101;&#114; severe infections such as sepsis &#097;&#110;&#100; opportunistic infections. &#105;&#102; latent tuberculosis &#105;&#115; diagnosed, &#097;&#112;&#112;&#114;&#111;&#112;&#114;&#105;&#097;&#116;&#101; treatment for latent tuberculosis must be initiated &#119;&#105;&#116;&#104; anti-tuberculosis prophylaxis therapy before starting treatment &#119;&#105;&#116;&#104; HUMIRA, &#097;&#110;&#100; in accordance &#119;&#105;&#116;&#104; local recommendations. Patients &#119;&#104;&#111; develop new infections while using HUMIRA &#115;&#104;&#111;&#117;&#108;&#100; be monitored closely &#097;&#110;&#100; undergo &#097; complete diagnostic evaluation. HUMIRA &#115;&#104;&#111;&#117;&#108;&#100; be discontinued &#105;&#102; &#097; patient develops &#097; new serious infection &#111;&#114; sepsis, &#117;&#110;&#116;&#105;&#108; &#116;&#104;&#101; infection &#105;&#115; controlled. Physicians &#115;&#104;&#111;&#117;&#108;&#100; exercise caution when &#099;&#111;&#110;&#115;&#105;&#100;&#101;&#114;&#105;&#110;&#103; &#117;&#115;&#101; of HUMIRA in patients &#119;&#105;&#116;&#104; &#097; history of recurring infection &#111;&#114; &#119;&#105;&#116;&#104; underlying conditions that may predispose patients to infections. </p>
<p> TNF-blocking agents &#104;&#097;&#118;&#101; been associated &#119;&#105;&#116;&#104; reactivation of hepatitis B (HBV) in patients &#119;&#104;&#111; &#097;&#114;&#101; chronic carriers of &#116;&#104;&#101; virus. Some cases &#104;&#097;&#118;&#101; been fatal. Patients at risk for HBV infection &#115;&#104;&#111;&#117;&#108;&#100; be evaluated for prior evidence of HBV infection before initiating HUMIRA. Carriers of HBV &#119;&#104;&#111; &#097;&#114;&#101; treated &#119;&#105;&#116;&#104; HUMIRA &#115;&#104;&#111;&#117;&#108;&#100; be closely monitored for active HBV infection throughout therapy &#097;&#110;&#100; for &#115;&#101;&#118;&#101;&#114;&#097;&#108; months following termination of therapy. </p>
<p> TNF-antagonists, including HUMIRA, &#104;&#097;&#118;&#101; been associated in rare cases &#119;&#105;&#116;&#104; demyelinating disease including multiple sclerosis. Serious allergic reactions &#104;&#097;&#118;&#101; been reported &#118;&#101;&#114;&#121; rarely following HUMIRA administration. </p>
<p> More cases of malignancies including lymphoma &#104;&#097;&#118;&#101; been observed among patients receiving &#097; TNF-antagonist compared &#119;&#105;&#116;&#104; control patients in clinical trials. However, &#116;&#104;&#101; occurrence was rare. Furthermore, &#116;&#104;&#101;&#114;&#101; &#105;&#115; &#097;&#110; increased background lymphoma risk in rheumatoid arthritis patients &#119;&#105;&#116;&#104; long-standing, highly active, inflammatory disease, &#119;&#104;&#105;&#099;&#104; complicates &#116;&#104;&#101; risk estimation. &#119;&#105;&#116;&#104; &#116;&#104;&#101; current knowledge, &#097; &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101; risk for &#116;&#104;&#101; development of lymphomas &#111;&#114; &#111;&#116;&#104;&#101;&#114; malignancies in patients treated &#119;&#105;&#116;&#104; &#097; TNF-antagonist &#099;&#097;&#110;&#110;&#111;&#116; be excluded. </p>
<p> Rare postmarketing cases of hepatosplenic T-cell lymphoma, &#097; disease &#119;&#105;&#116;&#104; &#097; &#118;&#101;&#114;&#121; aggressive &#097;&#110;&#100; &#117;&#115;&#117;&#097;&#108;&#108;&#121; fatal outcome, &#104;&#097;&#118;&#101; been identified in patients treated &#119;&#105;&#116;&#104; adalimumab. Some of &#116;&#104;&#101;&#115;&#101; cases occurred in young adult patients &#111;&#110; concomitant treatment &#119;&#105;&#116;&#104; azathioprine &#111;&#114; 6-mercaptopurine used for Crohn&#8217;s disease. &#097; risk for &#116;&#104;&#101; development of hepatosplenic T-cell lymphoma in patients treated &#119;&#105;&#116;&#104; HUMIRA &#099;&#097;&#110;&#110;&#111;&#116; be excluded. </p>
<p> &#097;&#108;&#108; patients, &#097;&#110;&#100; in particular patients &#119;&#105;&#116;&#104; &#097; medical history of extensive immunosuppressant therapy &#111;&#114; psoriasis patients &#119;&#105;&#116;&#104; &#097; history of PUVA treatment, &#115;&#104;&#111;&#117;&#108;&#100; be examined for &#116;&#104;&#101; presence of non-melanoma skin cancer prior to &#097;&#110;&#100; during treatment &#119;&#105;&#116;&#104; HUMIRA. </p>
<p> Rare reports of pancytopenia including aplastic anaemia &#104;&#097;&#118;&#101; been reported &#119;&#105;&#116;&#104; TNF-blocking agents. Adverse events of &#116;&#104;&#101; haematologic system, including medically significant cytopenia &#104;&#097;&#118;&#101; been infrequently reported &#119;&#105;&#116;&#104; HUMIRA. </p>
<p> Patients &#111;&#110; HUMIRA may receive concurrent vaccinations, &#101;&#120;&#099;&#101;&#112;&#116; for live vaccines. Juvenile patients &#115;&#104;&#111;&#117;&#108;&#100; be brought &#117;&#112; to date &#119;&#105;&#116;&#104; &#097;&#108;&#108; immunisations prior to initiating HUMIRA therapy, &#105;&#102; &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101;. </p>
<p> In clinical studies &#119;&#105;&#116;&#104; another TNF-antagonist, &#097; higher rate of serious congestive heart failure (CHF) related adverse events including worsening CHF &#097;&#110;&#100; new onset CHF &#104;&#097;&#118;&#101; been reported. Cases of worsening CHF &#104;&#097;&#118;&#101; also been reported in patients receiving HUMIRA. Physicians &#115;&#104;&#111;&#117;&#108;&#100; exercise caution when using HUMIRA in patients &#119;&#105;&#116;&#104; heart failure &#097;&#110;&#100; monitor &#116;&#104;&#101;&#109; carefully. </p>
<p> &#116;&#104;&#101; combination of HUMIRA &#097;&#110;&#100; anakinra &#111;&#114; HUMIRA &#097;&#110;&#100; abatacept &#105;&#115; not recommended. </p>
<p> Adverse Events at &#108;&#101;&#097;&#115;&#116; possibly causally related to HUMIRA include &#118;&#101;&#114;&#121; common events (reported &#098;&#121; &gt;1/10 patients) respiratory tract infections (including lower &#097;&#110;&#100; upper respiratory tract infection, pneumonia, sinusitis, pharyngitis, nasopharyngitis, pneumonia herpes viral), leucopaenia (including neutropaenia, agranulocytosis), anaemia, lipids increased, headache, abdominal pain, nausea &#097;&#110;&#100; vomiting, liver enzymes elevated, rash (including exfoliative rash), musculoskeletal pain, injection site reaction (including injection site erythema); common events (reported &#098;&#121; &gt;1/100 &#098;&#117;&#116; &lt; 1/10 patients): systemic infections (including sepsis, candidiasis, influenza), intestinal infections (including gastroenteritis viral), skin &#097;&#110;&#100; soft tissue infections (including paronychia, cellulitis, impetigo, necrotising fasciitis, herpes zoster), ear infections, oral infections (including herpes simplex, oral herpes, tooth infections), reproductive tract infections (including vulvovaginal mycotic infection), urinary tract infections (including pyelonephritis), fungal infections, benign neoplasm, skin cancer excluding melanoma (including basal cell carcinoma, squamous cell carcinoma), thrombocytopaenia, leucocytosis, hypersensitivity, allergies (including seasonal allergy), hypokalaemia, uric acid increased, blood sodium abnormal, hypocalcaemia, hyperglycemia, hypophosphotemia, blood potassium increased, mood alterations (including depression), anxiety, insomnia, paraesthesias (including hypoaesthesia), migraine, sciatica, visual impairment, conjunctivitis, vertigo, tachycardia, hypertension, flushing, haematoma, cough, asthma, dyspnoea, GI haemorrhage, dyspepsia, gastroesophageal reflux disease, sicca syndrome, pruritus, urticaria, bruising (including purpura), dermatitis (including eczema), onychoclasis, hyperhydrosis, muscle spasms (including blood creatine phosphokinase increased), haematuria, renal impairment, chest pain, oedema, coagulation &#097;&#110;&#100; bleeding disorders (including activated partial thromboplastin time prolonged), autoantibody test positive (including double stranded DNA antibody), blood lactate dehydrogenase increased, impaired healing. </p>
<p> Adverse drug reactions reported post-marketing include hepatosplenic T-cell lymphoma, anaphylaxis, demyelinating disorders (including optic neuritis, Guillain-Barre syndrome), cerebrovascular accident, intestinal perforation, reactivation of hepatitis B, cutaneous vasculitis, Stevens-Johnson syndrome, angioedema, new onset &#111;&#114; worsening of psoriasis (including palmoplantar pustular psoriasis), lupus-like syndrome, &#097;&#110;&#100; myocardial infarction. </p>
<p> &#097;&#098;&#111;&#117;&#116; Abbott </p>
<p> Abbott &#105;&#115; &#097; global, broad-based health care company devoted to &#116;&#104;&#101; discovery, development, manufacture &#097;&#110;&#100; marketing of pharmaceuticals &#097;&#110;&#100; medical products, including nutritionals, devices &#097;&#110;&#100; diagnostics. &#116;&#104;&#101; company employs nearly 90,000 people &#097;&#110;&#100; markets its products in more &#116;&#104;&#097;&#110; 130 countries. </p>
<p> Abbott&#8217;s news releases &#097;&#110;&#100; &#111;&#116;&#104;&#101;&#114; information &#097;&#114;&#101; &#097;&#118;&#097;&#105;&#108;&#097;&#098;&#108;&#101; &#111;&#110; &#116;&#104;&#101; company&#8217;s website at abbott.com. </p></p>
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		<title>Medtronic: Expert Panel Publishes Findings on Benefits of Underutilized Intrathecal Baclofen Therapy for Severe Spasticity in Multiple Sclerosis Patients &#8211; News Press Release</title>
		<link>http://symptomadvice.com/medtronic-expert-panel-publishes-findings-on-benefits-of-underutilized-intrathecal-baclofen-therapy-for-severe-spasticity-in-multiple-sclerosis-patients-news-press-release/</link>
		<comments>http://symptomadvice.com/medtronic-expert-panel-publishes-findings-on-benefits-of-underutilized-intrathecal-baclofen-therapy-for-severe-spasticity-in-multiple-sclerosis-patients-news-press-release/#comments</comments>
		<pubDate>Tue, 08 Feb 2011 10:00:08 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[nervous symptoms]]></category>
		<category><![CDATA[mdt]]></category>
		<category><![CDATA[ms patients]]></category>
		<category><![CDATA[negative impact]]></category>
		<category><![CDATA[neurology]]></category>
		<category><![CDATA[nyse]]></category>
		<category><![CDATA[quality of life]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/medtronic-expert-panel-publishes-findings-on-benefits-of-underutilized-intrathecal-baclofen-therapy-for-severe-spasticity-in-multiple-sclerosis-patients-news-press-release/</guid>
		<description><![CDATA[A new scientific article &#104;&#097;&#115; &#098;&#101;&#101;&#110; published demonstrating &#116;&#104;&#101; profound impact of spasticity &#111;&#110; patients with multiple sclerosis &#097;&#110;&#100; &#116;&#104;&#101; benefits &#097;&#110;&#100; underutilization of intrathecal baclofen (ITB) therapy from Medtronic, &#105;&#110;&#099;. (NYSE: MDT) as a treatment option &#102;&#111;&#114; these patients. &#116;&#104;&#101; paper, published &#116;&#104;&#105;&#115; week as &#097;&#110; OnlineFirst article in Multiple Sclerosis Journal,recommends physician evaluation [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2011/02/1297159208-69.jpg%3F1266889078" style="float:left;clear:both;margin:0 15px 15px 0" />
<p>A new scientific article &#104;&#097;&#115; &#098;&#101;&#101;&#110; published demonstrating &#116;&#104;&#101; profound impact of spasticity &#111;&#110; patients with multiple sclerosis &#097;&#110;&#100; &#116;&#104;&#101; benefits &#097;&#110;&#100; underutilization of intrathecal baclofen (ITB) therapy from Medtronic, &#105;&#110;&#099;. (NYSE: MDT) as a treatment option &#102;&#111;&#114; these patients. &#116;&#104;&#101; paper, published &#116;&#104;&#105;&#115; week as &#097;&#110; OnlineFirst article in Multiple Sclerosis Journal,recommends physician evaluation of ITB therapy as a treatment option &#102;&#111;&#114; patients at &#097;&#108;&#108; clinical stages of MS &#119;&#104;&#111; &#097;&#114;&#101; intolerant of &#111;&#114; unresponsive &#116;&#111; oral spasticity therapies. </p>
<p>“Severe spasticity &#105;&#115; a debilitating condition that &#099;&#097;&#110; &#104;&#097;&#118;&#101; a negative impact &#111;&#110; quality of life of patients with MS. &#119;&#104;&#105;&#108;&#101; oral medications work &#116;&#111; treat spasticity in &#115;&#111;&#109;&#101; individuals, I see patients every day &#119;&#104;&#111; can’t tolerate &#116;&#104;&#101; &#115;&#105;&#100;&#101; effects of large doses of medication &#110;&#101;&#099;&#101;&#115;&#115;&#097;&#114;&#121; &#116;&#111; treat &#116;&#104;&#101; &#109;&#111;&#115;&#116; severe cases,” said Mary Hughes, M.D., &#111;&#110;&#101; of &#116;&#104;&#101; article’s authors &#097;&#110;&#100; chair, Division of Neurology, University Medical Group, Greenville Hospital System University Medical Center in Greenville, S.C. “The strong collection of clinical results &#111;&#110; &#116;&#104;&#101; &#117;&#115;&#101; of ITB therapy in MS patients points &#116;&#111; a clear &#110;&#101;&#101;&#100; &#102;&#111;&#114; physicians &#116;&#111; help MS patients control their spasticity &#097;&#110;&#100; restore quality of life with options like ITB therapy, &#119;&#104;&#105;&#099;&#104; &#105;&#115; safe &#097;&#110;&#100; effective in carefully selected patients.” </p>
<p>The expert panel of authors, including leading MS clinicians from &#116;&#104;&#101; United States &#097;&#110;&#100; Europe, combined &#104;&#097;&#115; &#109;&#111;&#114;&#101; &#116;&#104;&#097;&#110; 100 years of experience in MS management &#097;&#110;&#100; &#104;&#097;&#115; treated &#109;&#111;&#114;&#101; &#116;&#104;&#097;&#110; 1,500 MS patients worldwide. &#116;&#104;&#101; article includes a review of literature &#111;&#110; ITB therapy &#102;&#111;&#114; spasticity in MS &#097;&#110;&#100; &#112;&#114;&#111;&#118;&#105;&#100;&#101;&#115; expert opinion of &#116;&#104;&#101; panel &#114;&#101;&#103;&#097;&#114;&#100;&#105;&#110;&#103; patient selection &#097;&#110;&#100; management of ITB therapy in MS patients. Medtronic sponsored &#116;&#104;&#101; panel’s meeting &#097;&#110;&#100; paper development. </p>
<p>According &#116;&#111; survey results &#119;&#105;&#116;&#104;&#105;&#110; &#116;&#104;&#101; research summary, 84 percent of patients with MS reported at least &#115;&#111;&#109;&#101; symptoms of spasticity, with 30 percent reporting moderate &#116;&#111; severe symptoms. Of &#116;&#104;&#101; 13 percent of MS patients &#119;&#104;&#111; may be candidates &#102;&#111;&#114; ITB therapy, &#111;&#110;&#108;&#121; 1 percent of patients stated &#116;&#104;&#101;&#121; were receiving &#116;&#104;&#101; therapy. &#104;&#111;&#119;&#101;&#118;&#101;&#114;, current data &#105;&#110;&#100;&#105;&#099;&#097;&#116;&#101; that ITB therapy effectively &#097;&#110;&#100; significantly reduces severe spasticity in ambulatory &#097;&#110;&#100; non-ambulatory patients with MS. </p>
<p>The expert panel noted that &#116;&#104;&#101; main barrier &#116;&#111; &#116;&#104;&#101; &#117;&#115;&#101; of ITB therapy &#105;&#115; that many physicians do not present ITB as a therapeutic option that &#105;&#115; safe, effective &#097;&#110;&#100; well-tolerated. &#116;&#104;&#105;&#115; often occurs due &#116;&#111; a lack of physician understanding of quality of life issues caused by spasticity, potential ITB benefits &#097;&#110;&#100; appropriate patient selection, as &#119;&#101;&#108;&#108; as their focus &#111;&#110; disease-modifying therapies &#114;&#097;&#116;&#104;&#101;&#114; &#116;&#104;&#097;&#110; symptom control. </p>
<p>“This article &#105;&#115; a &#118;&#101;&#114;&#121; powerful analysis of &#116;&#104;&#101; &#110;&#101;&#101;&#100; &#102;&#111;&#114; greater consideration of ITB therapy by clinicians &#119;&#104;&#111; manage MS,” said Tom Tefft, senior vice president &#097;&#110;&#100; president of &#116;&#104;&#101; Neuromodulation business at Medtronic. “We &#097;&#114;&#101; hopeful that &#116;&#104;&#105;&#115; paper will encourage &#109;&#111;&#114;&#101; physicians &#116;&#111; offer &#116;&#104;&#101; therapy &#116;&#111; appropriate patients.” </p>
<p><strong>About Multiple Sclerosis &#097;&#110;&#100; Spasticity</strong></p>
<p>Approximately 300,000 Americans &#104;&#097;&#118;&#101; MS, a chronic, often disabling disease of &#116;&#104;&#101; central nervous system. Symptoms may include abnormal fatigue, impaired vision, loss of balance &#097;&#110;&#100; muscle coordination, slurred speech, tremors, spasticity, bladder &#097;&#110;&#100; bowel problems, difficulty walking, short-term memory loss, mood swings, &#097;&#110;&#100;, in severe cases, partial &#111;&#114; complete paralysis. Spasticity &#099;&#097;&#110; occur when &#116;&#104;&#101; &#112;&#097;&#114;&#116; of &#116;&#104;&#101; brain that controls voluntary movements &#105;&#115; damaged &#111;&#114; injured &#097;&#110;&#100; results in tight, stiff muscles. In addition &#116;&#111; being &#111;&#110;&#101; possible symptom of MS, spasticity &#097;&#108;&#115;&#111; &#099;&#097;&#110; be a symptom of cerebral palsy, brain injury, spinal cord injury &#111;&#114; stroke. &#102;&#111;&#114; &#115;&#111;&#109;&#101; people, &#116;&#104;&#101; condition &#105;&#115; so severe that &#105;&#116; &#105;&#115; impossible &#116;&#111; voluntarily relax muscles. </p>
<p><strong>About ITB Therapy</strong></p>
<p>Medtronic ITB Therapy &#117;&#115;&#105;&#110;&#103; &#116;&#104;&#101; SynchroMed® II pump &#105;&#115; &#116;&#104;&#101; &#102;&#105;&#114;&#115;&#116; &#097;&#110;&#100; &#111;&#110;&#108;&#121; fully programmable implantable drug pump &#097;&#118;&#097;&#105;&#108;&#097;&#098;&#108;&#101; in &#116;&#104;&#101; United States &#116;&#111; treat severe spasticity. &#102;&#105;&#114;&#115;&#116; approved in &#116;&#104;&#101; United States in 1992, ITB &#105;&#115; a complete drug delivery solution &#116;&#111; optimize spasticity treatment &#097;&#110;&#100; maximize function. &#116;&#104;&#101; therapy delivers a baclofen injection directly &#116;&#111; &#116;&#104;&#101; intrathecal space &#119;&#104;&#101;&#114;&#101; fluid flows &#097;&#114;&#111;&#117;&#110;&#100; &#116;&#104;&#101; spinal cord in patients with severe spasticity. &#109;&#111;&#114;&#101; information &#105;&#115; &#097;&#118;&#097;&#105;&#108;&#097;&#098;&#108;&#101; at medtronic.com/your-health/severe-spasticity/about/index.htm</p>
<p><strong>About Medtronic</strong></p>
<p>Medtronic, &#105;&#110;&#099;. (medtronic.com), headquartered in Minneapolis, &#105;&#115; &#116;&#104;&#101; global leader in medical technology &#8211; alleviating pain, restoring health, &#097;&#110;&#100; extending life &#102;&#111;&#114; millions of people &#097;&#114;&#111;&#117;&#110;&#100; &#116;&#104;&#101; world. </p>
<p><strong>Any forward-looking statements &#097;&#114;&#101; subject &#116;&#111; risks &#097;&#110;&#100; uncertainties such as those described in Medtronic&#8217;s periodic reports &#111;&#110; file with &#116;&#104;&#101; Securities &#097;&#110;&#100; Exchange Commission. Actual results may differ materially from anticipated results.</strong></p>
<p>Business Wirebusinesswire.com/
<p>Last updated &#111;&#110;: 05/02/2011 08:00:02</p></p>
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		<title>Economic Evaluation of FAME Trial Confirms Using FFR in Treatment of Coronary Artery Disease Is Cost-Effective</title>
		<link>http://symptomadvice.com/economic-evaluation-of-fame-trial-confirms-using-ffr-in-treatment-of-coronary-artery-disease-is-cost-effective/</link>
		<comments>http://symptomadvice.com/economic-evaluation-of-fame-trial-confirms-using-ffr-in-treatment-of-coronary-artery-disease-is-cost-effective/#comments</comments>
		<pubDate>Fri, 17 Dec 2010 08:34:12 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[pain symptoms]]></category>
		<category><![CDATA[business wire]]></category>
		<category><![CDATA[evaluation trial]]></category>
		<category><![CDATA[nyse]]></category>
		<category><![CDATA[patient care]]></category>
		<category><![CDATA[percutaneous coronary intervention]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/economic-evaluation-of-fame-trial-confirms-using-ffr-in-treatment-of-coronary-artery-disease-is-cost-effective/</guid>
		<description><![CDATA[Results demonstrate FFR-guided treatment offers cost-saving benefits to &#116;&#104;&#101; U.S. healthcare &#115;&#121;&#115;&#116;&#101;&#109; ST. PAUL, Minn.&#8211;(BUSINESS WIRE)&#8211;St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced &#116;&#104;&#101; publication of results from &#097;&#110; economic evaluation of &#116;&#104;&#101; landmark FAME (Fractional Flow Reserve (FFR) &#118;&#115;. Angiography &#105;&#110; Multivessel Evaluation) trial, which confirmed FFR-guided percutaneous coronary intervention [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2010/12/1292574853-46.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p> Results demonstrate FFR-guided treatment offers cost-saving benefits to &#116;&#104;&#101; U.S. healthcare &#115;&#121;&#115;&#116;&#101;&#109; </p>
<p>ST. PAUL, Minn.&#8211;(BUSINESS WIRE)&#8211;St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced &#116;&#104;&#101; publication of results from &#097;&#110; economic evaluation of &#116;&#104;&#101; landmark FAME (Fractional Flow Reserve (FFR) &#118;&#115;. Angiography &#105;&#110; Multivessel Evaluation) trial, which confirmed FFR-guided percutaneous coronary intervention (PCI) &#105;&#110; patients &#119;&#105;&#116;&#104; multivessel coronary artery disease improves patient outcomes &#097;&#110;&#100; offers cost-saving benefits to &#116;&#104;&#101; U.S. healthcare &#115;&#121;&#115;&#116;&#101;&#109;. </p>
<p>&#8220;This study &#097;&#108;&#115;&#111; reflects &#116;&#104;&#101; benefits this technology &#104;&#097;&#115; &#111;&#110; patient care &#097;&#110;&#100; &#116;&#104;&#101; advantages &#105;&#116; offers to &#116;&#104;&#101; healthcare &#115;&#121;&#115;&#116;&#101;&#109; as a &#119;&#104;&#111;&#108;&#101;.&#8221;</p>
<p> &#116;&#104;&#101; one-year results, published &#105;&#110; <i>Circulation</i>, demonstrate &#116;&#104;&#097;&#116; treatment guided &#098;&#121; St. Jude Medical’s FFR measurement &#115;&#121;&#115;&#116;&#101;&#109; was cost-saving, finding &#109;&#101;&#097;&#110; &#111;&#118;&#101;&#114;&#097;&#108;&#108; costs &#097;&#115;&#115;&#111;&#099;&#105;&#097;&#116;&#101;&#100; &#119;&#105;&#116;&#104; &#116;&#104;&#101; FFR-guided group significantly &#108;&#111;&#119;&#101;&#114; than &#116;&#104;&#101; group guided &#098;&#121; angiography &#097;&#108;&#111;&#110;&#101;. &#109;&#101;&#097;&#110; &#111;&#118;&#101;&#114;&#097;&#108;&#108; costs &#102;&#111;&#114; FFR-guided treatment was $14,300, compared to $16,700 &#102;&#111;&#114; angiography-guided treatment, &#119;&#105;&#116;&#104; cost savings occurring &#100;&#117;&#114;&#105;&#110;&#103; &#098;&#111;&#116;&#104; &#116;&#104;&#101; initial procedure, primarily &#100;&#117;&#101; to a decrease &#105;&#110; unnecessary drug-eluting stent &#117;&#115;&#101;, &#097;&#110;&#100; &#100;&#117;&#114;&#105;&#110;&#103; follow-up as a result of a decrease &#105;&#110; re-hospitalization &#097;&#110;&#100; fewer major adverse cardiac events (MACE). Results &#102;&#117;&#114;&#116;&#104;&#101;&#114; indicated &#116;&#104;&#097;&#116; MACE, such as death, myocardial infarction (heart attack) &#097;&#110;&#100; repeat revascularization, occurred &#105;&#110; 13.2 percent of patients &#119;&#104;&#111; received FFR-guided treatment, compared to 18.3 percent of patients &#119;&#104;&#111; received angiography-guided treatment. </p>
<p> “Economic evaluation of &#116;&#104;&#101; FAME study reveals &#116;&#104;&#097;&#116; FFR-guided percutaneous coronary intervention &#105;&#110; patients &#119;&#105;&#116;&#104; multivessel coronary disease is one of those rare situations &#105;&#110; which a new technology &#110;&#111;&#116; &#111;&#110;&#108;&#121; improves outcomes but &#097;&#108;&#115;&#111; conserves resources,” said William F. Fearon, M.D., associate professor, Stanford University Medical Center. “This study &#097;&#108;&#115;&#111; reflects &#116;&#104;&#101; benefits this technology &#104;&#097;&#115; &#111;&#110; patient care &#097;&#110;&#100; &#116;&#104;&#101; advantages &#105;&#116; offers to &#116;&#104;&#101; healthcare &#115;&#121;&#115;&#116;&#101;&#109; as a &#119;&#104;&#111;&#108;&#101;.” </p>
<p> Current data &#115;&#104;&#111;&#119; &#116;&#104;&#097;&#116; physiological assessment using FFR prior to placement of coronary stents helps physicians to &#098;&#101;&#116;&#116;&#101;&#114; optimize clinical outcomes &#098;&#121; determining which specific lesion &#111;&#114; lesions are responsible &#102;&#111;&#114; a patient&#8217;s ischemia (a deficiency of blood supply to &#116;&#104;&#101; heart caused &#098;&#121; blood restriction). &#105;&#110; addition, data have demonstrated &#116;&#104;&#097;&#116; FFR measurements can &#098;&#101; useful as &#097;&#110; alternative to noninvasive functional testing, &#097;&#110;&#100; to help assess &#097;&#110; abnormal narrowing &#105;&#110; a coronary artery &#102;&#111;&#114; patients &#119;&#105;&#116;&#104; anginal symptoms such as chest pain. </p>
<p> “St. Jude Medical believes FFR &#112;&#114;&#111;&#118;&#105;&#100;&#101;&#115; tremendous value to patients, physicians &#097;&#110;&#100; hospitals,” said Frank J. Callaghan, president of &#116;&#104;&#101; St. Jude Medical Cardiovascular Division. “Not &#111;&#110;&#108;&#121; is &#105;&#116; clinically effective, but &#105;&#116; is clear &#116;&#104;&#097;&#116; &#105;&#116; is a cost-effective treatment option &#102;&#111;&#114; hospitals. &#119;&#101; &#119;&#105;&#108;&#108; continue to provide physicians &#119;&#105;&#116;&#104; data &#116;&#104;&#097;&#116; &#102;&#117;&#114;&#116;&#104;&#101;&#114; demonstrate &#116;&#104;&#101; significant benefits this technology offers &#102;&#111;&#114; patients &#097;&#110;&#100; healthcare systems &#097;&#114;&#111;&#117;&#110;&#100; &#116;&#104;&#101; world.” </p>
<p> &#116;&#104;&#101; FAME study is a randomized, prospective, multi-center trial which enrolled 1,005 patients &#119;&#105;&#116;&#104; multivessel coronary artery disease. &#116;&#104;&#101; study compared outcomes &#102;&#111;&#114; patients whose treatment was guided &#098;&#121; FFR to those whose treatment was guided &#111;&#110;&#108;&#121; &#098;&#121; angiography. &#116;&#104;&#101; 12-month results, published &#105;&#110; &#116;&#104;&#101; January 15, 2009 issue of &#116;&#104;&#101; <i>New England Journal of Medicine</i>, demonstrated &#116;&#104;&#097;&#116; instances of MACE &#119;&#101;&#114;&#101; reduced &#098;&#121; 28 percent &#102;&#111;&#114; patients whose treatment was guided &#098;&#121; FFR &#114;&#097;&#116;&#104;&#101;&#114; than &#098;&#121; standard angiography &#097;&#108;&#111;&#110;&#101;. Based &#111;&#110; &#105;&#116;&#115; large size, multicenter nature, &#097;&#110;&#100; randomized prospective design, &#116;&#104;&#101; economic evaluation of &#116;&#104;&#101; FAME trial &#102;&#117;&#114;&#116;&#104;&#101;&#114; strengthens &#116;&#104;&#101; evidence supporting &#116;&#104;&#101; health economic advantage to performing FFR-guided percutaneous coronary intervention. </p>
<p> Two-year results, presented as a late-breaking trial &#100;&#117;&#114;&#105;&#110;&#103; &#116;&#104;&#101; 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference, demonstrated &#116;&#104;&#097;&#116; patients &#119;&#104;&#111; received FFR-guided treatment continued to experience improved outcomes over time, including a 34 percent risk reduction of death &#111;&#114; heart attack. </p>
<p> &#116;&#104;&#101; St. Jude Medical FFR measurement &#115;&#121;&#115;&#116;&#101;&#109; portfolio includes &#098;&#111;&#116;&#104; &#116;&#104;&#101; PressureWire™ Certus &#097;&#110;&#100; &#116;&#104;&#101; PressureWire Aeris™. &#116;&#104;&#101; PressureWire Certus was &#116;&#104;&#101; &#111;&#110;&#108;&#121; FFR guidewire &#117;&#115;&#101;&#100; &#105;&#110; &#116;&#104;&#101; FAME trial; &#116;&#104;&#101; PressureWire Aeris is &#116;&#104;&#101; industry&#8217;s &#111;&#110;&#108;&#121; wireless technology available, which requires &#110;&#111; additional equipment &#111;&#114; cabling &#105;&#110; &#116;&#104;&#101; cardiac catheterization laboratory. </p>
<p> <b>About Fractional Flow Reserve (FFR)</b> </p>
<p> Fractional Flow Reserve (FFR) is &#097;&#110; index determining &#116;&#104;&#101; functional severity of narrowings &#105;&#110; &#116;&#104;&#101; coronary arteries as measured &#098;&#121; PressureWire Certus &#097;&#110;&#100; PressureWire Aeris. FFR specifically identifies which coronary narrowings are responsible &#102;&#111;&#114; significantly obstructing &#116;&#104;&#101; flow of blood to a patients&#8217; heart muscle (called ischemia), &#097;&#110;&#100; &#105;&#116; is &#117;&#115;&#101;&#100; &#098;&#121; &#116;&#104;&#101; interventional cardiologist to direct coronary interventions &#097;&#110;&#100; assess results &#102;&#111;&#114; improved treatment outcomes. </p>
<p> <b>About St. Jude Medical</b> </p>
<p> St. Jude Medical develops medical technology &#097;&#110;&#100; services &#116;&#104;&#097;&#116; focus &#111;&#110; putting more control &#105;&#110;&#116;&#111; &#116;&#104;&#101; hands of those &#119;&#104;&#111; treat cardiac, neurological &#097;&#110;&#100; chronic pain patients worldwide. &#116;&#104;&#101; company is dedicated to advancing &#116;&#104;&#101; practice of medicine &#098;&#121; reducing risk wherever possible &#097;&#110;&#100; contributing to successful outcomes &#102;&#111;&#114; &#101;&#118;&#101;&#114;&#121; patient. St. Jude Medical is headquartered &#105;&#110; St. Paul, Minn. &#097;&#110;&#100; &#104;&#097;&#115; &#102;&#111;&#117;&#114; major focus areas &#116;&#104;&#097;&#116; include: cardiac rhythm management, atrial fibrillation, cardiovascular &#097;&#110;&#100; neuromodulation. &#102;&#111;&#114; more information, &#112;&#108;&#101;&#097;&#115;&#101; visit sjm.com. </p>
<p> <i><b>Forward-Looking Statements</b></i> </p>
<p> This news release contains forward-looking statements within &#116;&#104;&#101; meaning of &#116;&#104;&#101; Private Securities Litigation Reform Act of 1995 &#116;&#104;&#097;&#116; involve risks &#097;&#110;&#100; uncertainties. Such forward-looking statements include &#116;&#104;&#101; expectations, plans &#097;&#110;&#100; prospects &#102;&#111;&#114; &#116;&#104;&#101; Company, including potential clinical successes, anticipated regulatory approvals &#097;&#110;&#100; future product launches, &#097;&#110;&#100; projected revenues, margins, earnings &#097;&#110;&#100; market shares. &#116;&#104;&#101; statements &#109;&#097;&#100;&#101; &#098;&#121; &#116;&#104;&#101; Company are based upon management’s current expectations &#097;&#110;&#100; are subject to &#099;&#101;&#114;&#116;&#097;&#105;&#110; risks &#097;&#110;&#100; uncertainties &#116;&#104;&#097;&#116; could &#099;&#097;&#117;&#115;&#101; actual results to differ materially from those &#100;&#101;&#115;&#099;&#114;&#105;&#098;&#101;&#100; &#105;&#110; &#116;&#104;&#101; forward-looking statements. &#116;&#104;&#101;&#115;&#101; risks &#097;&#110;&#100; uncertainties include market conditions &#097;&#110;&#100; &#111;&#116;&#104;&#101;&#114; factors &#098;&#101;&#121;&#111;&#110;&#100; &#116;&#104;&#101; Company’s control &#097;&#110;&#100; &#116;&#104;&#101; risk factors &#097;&#110;&#100; &#111;&#116;&#104;&#101;&#114; cautionary statements &#100;&#101;&#115;&#099;&#114;&#105;&#098;&#101;&#100; &#105;&#110; &#116;&#104;&#101; Company’s filings &#119;&#105;&#116;&#104; &#116;&#104;&#101; SEC, including those &#100;&#101;&#115;&#099;&#114;&#105;&#098;&#101;&#100; &#105;&#110; &#116;&#104;&#101; Risk Factors &#097;&#110;&#100; Cautionary Statements sections of &#116;&#104;&#101; Company’s Quarterly Report &#111;&#110; Form 10-Q &#102;&#111;&#114; &#116;&#104;&#101; fiscal quarter &#101;&#110;&#100;&#101;&#100; October 2, 2010. &#116;&#104;&#101; Company does &#110;&#111;&#116; intend to update &#116;&#104;&#101;&#115;&#101; statements &#097;&#110;&#100; undertakes &#110;&#111; duty to &#097;&#110;&#121; person to provide &#097;&#110;&#121; such update &#117;&#110;&#100;&#101;&#114; &#097;&#110;&#121; circumstance. </p></p>
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		<title>Baxter and Kamada in GLASSIA Deal</title>
		<link>http://symptomadvice.com/baxter-and-kamada-in-glassia-deal/</link>
		<comments>http://symptomadvice.com/baxter-and-kamada-in-glassia-deal/#comments</comments>
		<pubDate>Tue, 24 Aug 2010 14:36:08 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[kidney symptoms]]></category>
		<category><![CDATA[baxter international]]></category>
		<category><![CDATA[medical product]]></category>
		<category><![CDATA[nyse]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/baxter-and-kamada-in-glassia-deal/</guid>
		<description><![CDATA[Zack, On Tuesday August 24, 2010, 8:42 &#097;&#109; EDT Medical product giant Baxter International &#105;&#110;&#099;. (NYSE: BAX &#8211; News) &#104;&#097;&#115; entered &#105;&#110;&#116;&#111; a definitive distribution agreement &#119;&#105;&#116;&#104; Israel-based biopharmaceuticals company Kamada &#108;&#116;&#100;. &#117;&#110;&#100;&#101;&#114; &#116;&#104;&#101; deal, &#105;&#116; &#104;&#097;&#115; secured exclusive marketing rights &#116;&#111; Kamada’s GLASSIA Alpha 1-Proteinase inhibitor &#105;&#110; &#116;&#104;&#101; U.S., Canada, Australia and New Zealand. [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2010/08/1282660568-49.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />Zack, On Tuesday August 24, 2010, 8:42 &#097;&#109; EDT
<p>Medical product giant <strong>Baxter International &#105;&#110;&#099;.</strong> (NYSE: BAX &#8211; News) &#104;&#097;&#115; entered &#105;&#110;&#116;&#111; a definitive distribution agreement &#119;&#105;&#116;&#104; Israel-based biopharmaceuticals company Kamada &#108;&#116;&#100;. &#117;&#110;&#100;&#101;&#114; &#116;&#104;&#101; deal, &#105;&#116; &#104;&#097;&#115; secured exclusive marketing rights &#116;&#111; Kamada’s GLASSIA Alpha 1-Proteinase inhibitor &#105;&#110; &#116;&#104;&#101; U.S., Canada, Australia and New Zealand. .</p>
<p>GLASSIA, &#116;&#104;&#101; &#102;&#105;&#114;&#115;&#116; and only liquid, ready-to-use Alpha1-Proteinase inhibitor, &#105;&#115; &#105;&#110;&#100;&#105;&#099;&#097;&#116;&#101;&#100; for &#116;&#104;&#101; treatment of emphysema (a lung disease) due &#116;&#111; Alpha 1 deficiency, also known &#097;&#115; Alpha1-Antitrypsin deficiency (AATD). &#116;&#104;&#101; drug was approved &#098;&#121; &#116;&#104;&#101; U.S. Food and Drug Administration (FDA) for &#116;&#104;&#105;&#115; indication &#105;&#110; July 2010. Kamada expects GLASSIA &#116;&#111; generate annual sales of roughly $40 million.</p>
<p>AATD &#105;&#115; &#097;&#110; under-diagnosed genetic disorder caused &#098;&#121; defective production of Alpha 1-Antitrypsin (A1AT), a naturally occurring protein, leading &#116;&#111; reduced A1AT activity &#105;&#110; &#116;&#104;&#101; blood and lungs. Roughly 100,000 people are estimated &#116;&#111; have inherited AATD &#105;&#110; &#116;&#104;&#101; U.S. &#108;&#101;&#115;&#115; &#116;&#104;&#097;&#110; 10% of &#116;&#104;&#105;&#115; population &#104;&#097;&#115; &#098;&#101;&#101;&#110; adequately diagnosed. Individuals &#119;&#105;&#116;&#104; AATD may eventually develop emphysema, and sometimes, liver failure. Common symptoms of AATD are shortage of breath and cough.</p>
<p>The distribution deal calls for &#097;&#110; upfront cash payment of $20 million &#098;&#121; Baxter &#116;&#111; Kamada and includes a provision, &#119;&#104;&#105;&#099;&#104; prevents &#116;&#104;&#101; latter from negotiating &#111;&#114; agreeing for GLASSIA &#105;&#110; &#111;&#116;&#104;&#101;&#114; markets for &#097;&#110; agreed period of time. Baxter &#104;&#097;&#115; also &#098;&#101;&#101;&#110; granted &#116;&#104;&#101; rights &#116;&#111; produce &#116;&#104;&#101; drug and secure associated regulatory approvals. Moreover, &#116;&#104;&#101; company may &#109;&#097;&#107;&#101; additional milestone payments of up &#116;&#111; $25 million on achievement of specific commercial and production-related landmarks and royalties (undisclosed) on future product sales.</p>
<p>Baxter &#105;&#115; expected &#116;&#111; launch GLASSIA &#105;&#110; &#116;&#104;&#101; U.S. during &#116;&#104;&#101; fourth quarter of 2010. &#116;&#104;&#101; company &#119;&#105;&#108;&#108; pursue &#116;&#111; obtain distribution licenses for &#116;&#104;&#101; drug &#105;&#110; &#116;&#104;&#101; &#111;&#116;&#104;&#101;&#114; countries &#105;&#110; &#119;&#104;&#105;&#099;&#104; &#105;&#116; &#104;&#097;&#115; secured commercial rights. &#116;&#104;&#101; deal underscores Baxter’s commitment &#116;&#111; &#116;&#104;&#101; awareness and early diagnosis of AATD. &#116;&#104;&#101; company sponsors &#116;&#104;&#101; AlphaTest diagnostic kit and &#115;&#111; &#102;&#097;&#114; &#104;&#097;&#115; assisted &#105;&#110; testing &#109;&#111;&#114;&#101; &#116;&#104;&#097;&#110; 80,000 people for AATD.</p>
<p>Baxter &#105;&#115; a leading global medical products and services company that develops, manufactures and markets products &#116;&#111; treat hemophilia (a bleeding disorder), kidney disease and infectious diseases. &#116;&#104;&#101; company’s main competitors are <strong>Becton, Dickinson and Company</strong> (NYSE: BDX &#8211; News) and <strong>Johnson &amp; Johnson</strong> (NYSE: JNJ &#8211; News).</p>
<p>Baxter’s products are primarily life-sustaining, offering a natural hedge &#097;&#103;&#097;&#105;&#110;&#115;&#116; soft economic conditions. However, &#116;&#104;&#101; company faces significant risks from product recalls, &#119;&#104;&#105;&#099;&#104; may drag its bottom line.</p>
</p>
<p>BAXTER INTL INC (BAX): Read &#116;&#104;&#101; Full Research Report</p>
<p>Zacks Investment Research</p></p>
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