ScienceDaily (Mar. 9, 2011) — Implanting electrodes into a pea-sized part of the brain can dramatically improve life for people with severe cervical dystonia — a rare but extremely debilitating condition that causes painful, twisting neck muscle spasms — according to the results of a pilot study led by Jill Ostrem, MD and Philip Starr, MD PhD at the University of California, San Francisco.

Today, people with cervical dystonia can be treated with medications or injections of botulinum toxin (e.g., Botox®), which interrupt signals from the brain that cause these spasms. However, those treatments do not provide adequate relief for all patients.

Over the last decade, doctors at UCSF and elsewhere have turned to a technique called deep brain stimulation to help people with debilitating dystonia. also used to treat Parkinson’s disease and the neurological disorder essential tremor, the technique is like putting a pacemaker inside a heart patient’s chest — except that deep brain stimulation requires a neurosurgeon to implant electrodes inside the brain.

Scientists are not sure exactly why deep brain stimulation works. the electrodes deliver electric current to tiny parts of the brain, likely altering abnormal brain circuitry and alleviating symptoms by overriding the signals coming from those parts of the brain.

Traditionally doctors have treated cervical dystonia with deep brain stimulation by targeting a brain nucleus known as the "globus pallidus internus." Reporting in the journal Neurology, the UCSF team described the results of the first detailed clinical study looking at deep brain stimulation targeting a completely different part of the brain: the "subthalamic nucleus."

"This target is very widely used for Parkinson’s disease but not widely used for dystonia," said Starr, a professor of neurological surgery at UCSF and senior author of the paper.

The study, led by Ostrem, an associate professor of neurology at UCSF, involved nine patients followed for one year after surgery. "Patients in this study had failed medical treatments, but with the surgery, they were able to improve their movements and quality of life — as well as overcome some of their disability and pain," said Ostrem.

Video analysis and standard measures of dystonia showed the surgeries lowered pain, reduced spasms and improved the overall quality of life without causing serious side effects.

The team is now planning to enroll more patients into a longer study following outcomes for three years post-surgery.

"Medications and botulinum toxin injections still remain the first line of treatment," Ostrem said, "but for those who are really still suffering, we think DBS using this new stimulation location offers another choice for them."

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the above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of California – San Francisco.

Journal Reference:

1. J. L. Ostrem, C. a. Racine, G. a. Glass, J. K. Grace, M. M. Volz, S. L. Heath, P. a. Starr. Subthalamic nucleus deep brain stimulation in primary cervical dystonia. Neurology, 2011; 76 (10): 870 DOI: 10.1212/WNL.0b013e31820f2e4f

Note: if no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Known as parent-child interaction therapy, the play-based technique has been used successfully to treat hyperactivity and disruptive disorders. The researchers adapted it, adding a focus on emotional development, to test whether it could help parents teach their children how to regulate negative emotions, such as guilt and sadness.

Play therapy sessions put parents and their children in one room while a therapist observes from a nearby room.

Results from the pilot study are published online in the journal Depression and Anxiety. Investigators caution that the findings are preliminary, involving only eight preschoolers, but they call the outcomes dramatic. Depression symptoms improved in all of the children studied.

“There was a very large effect,” says principal investigator Joan L. Luby, MD, professor of child psychiatry. “from our past research, we know that children as young as three can suffer from clinical depression, but how to treat it is an open question. Most infant-preschool mental health providers want to avoid drug treatment, and there is evidence that psychosocial interventions can be uniquely effective in young children. our findings certainly suggest that may be true for depression.”

Therapy took place during 14 sessions over 18 weeks. Depression severity scores decreased 44 percent. Following therapy, most child participants no longer met the diagnostic criteria for depression.

The study was conducted as an open trial. That is, all children received the investigational play therapy. Luby’s group since has conducted a more rigorous randomized, controlled study that put some parents and preschoolers into play therapy, while other parents met weekly with a psychologist to learn about normal emotional development. The researchers currently are analyzing the data from that study.

The original therapy was developed in the 1970s by Sheila M. Eyberg, PhD, distinguished professor of clinical and health psychology at the University of Florida in Gainesville.

“The original form of parent-child interaction therapy had two components,” says lead author Shannon N. Lenze, PhD, an instructor in the Department of Psychiatry. “One was a child-directed interaction, and the other was parent-directed. The first encourages the parent to use effective praising techniques, to play games the child wants to play, to get down on the child’s level and be enthusiastic. The second component teaches the parent about effective discipline using a very specific ‘time out’ to help the child learn to obey parent commands.”

A third novel component, which was developed for this study, involves emotions and helps parents learn to help their child more effectively regulate them.

“It’s designed to help parents understand what’s going on with their child,” Lenze says. “It also trains parents in how to show empathy for the child and the emotions that child is displaying, as well as what to do about those emotions.”

The focus on emotions comes from the belief that emotionally healthy people are able to experience a broad range of emotions, both positive and negative. Healthy people, Luby says, can feel emotions at peak intensity but also can regulate them. Depressed children often can’t do that.

“It’s healthy to be able to experience sadness or guilt, but it’s not healthy to be overwrought with guilt and preoccupied with sad things,” Luby explains. “We work to help parents tolerate a child’s emotion, as opposed to just trying to quash it or to change the subject and distract the child, which is a very typical parental technique.”

During therapy sessions, therapists like Lenze observe parent-child interactions through a one-way mirror. they talk directly to the parents, who wear an earpiece and a microphone, allowing the therapists to coach them while they are interacting with their child. this allows the therapist to deliver specific instructions about how to deal with the child’s emotions in real time.

“That’s one of the interesting techniques that Eyberg developed,” Luby says. “because the therapist is watching and coaching, the parent becomes the ‘arm of the therapist’ during the treatment session, which puts the parent and therapist on the same page. I think that may be one of the reasons why the technique seems to be so effective.”

Another reason may involve brain development.

“The brain is undergoing tremendous, rapid change during this period of development,” Luby says. “We think it is important to identify depression and intervene early so that we might prevent it from becoming a chronic and relapsing disorder.”