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	<title>Symptom Advice .com &#187; sle</title>
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		<title>Croup Cough in Young Children</title>
		<link>http://symptomadvice.com/croup-cough-in-young-children/</link>
		<comments>http://symptomadvice.com/croup-cough-in-young-children/#comments</comments>
		<pubDate>Sun, 26 Dec 2010 22:00:44 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[cough symptoms]]></category>
		<category><![CDATA[croup]]></category>
		<category><![CDATA[emergency room]]></category>
		<category><![CDATA[hard time]]></category>
		<category><![CDATA[sle]]></category>
		<category><![CDATA[sweet son]]></category>

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		<description><![CDATA[If &#121;&#111;&#117;&#114; young child &#104;&#097;&#115; &#101;&#118;&#101;&#114; awakened in &#116;&#104;&#101; middle of &#116;&#104;&#101; night &#099;&#114;&#121;&#105;&#110;&#103;, having difficulty breathing, and &#119;&#105;&#116;&#104; a cough &#116;&#104;&#097;&#116; sounds similar &#116;&#111; &#116;&#104;&#097;&#116; of a barking seal, then &#121;&#111;&#117; &#097;&#114;&#101; &#097;&#108;&#114;&#101;&#097;&#100;&#121; familiar &#119;&#105;&#116;&#104; a childhood illness commonly &#107;&#110;&#111;&#119;&#110; as croup. Personally, I didn&#8217;t have any &#105;&#100;&#101;&#097; &#119;&#104;&#097;&#116; croup was &#117;&#110;&#116;&#105;&#108; my then [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2010/12/1293400845-42.jpg%3Fw%3D480%26h%3D310" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p>If &#121;&#111;&#117;&#114; young child &#104;&#097;&#115; &#101;&#118;&#101;&#114; awakened in &#116;&#104;&#101; middle of &#116;&#104;&#101; night &#099;&#114;&#121;&#105;&#110;&#103;, having difficulty breathing, and &#119;&#105;&#116;&#104; a cough &#116;&#104;&#097;&#116; sounds similar &#116;&#111; &#116;&#104;&#097;&#116; of a barking seal, then &#121;&#111;&#117; &#097;&#114;&#101; &#097;&#108;&#114;&#101;&#097;&#100;&#121; familiar &#119;&#105;&#116;&#104; a childhood illness commonly &#107;&#110;&#111;&#119;&#110; as croup.</p>
<p>Personally, I didn&#8217;t have any &#105;&#100;&#101;&#097; &#119;&#104;&#097;&#116; croup was &#117;&#110;&#116;&#105;&#108; my then 2-year-old son woke up &#100;&#117;&#114;&#105;&#110;&#103; &#116;&#104;&#101; middle of &#116;&#104;&#101; night &#119;&#105;&#116;&#104; &#116;&#104;&#105;&#115; horrible, horrible cough. I couldn&#8217;t &#098;&#101;&#108;&#105;&#101;&#118;&#101; &#116;&#104;&#105;&#115; loud barking noise was coming out of my sweet son. He was having &#115;&#117;&#099;&#104; a hard time breathing &#116;&#104;&#097;&#116; I rushed him &#116;&#111; &#116;&#104;&#101; emergency room and spent four &#116;&#111; &#102;&#105;&#118;&#101; hours &#116;&#104;&#101;&#114;&#101; having &#104;&#105;&#115; chest x-rayed and having a doctor look at him, only &#116;&#111; &#102;&#105;&#110;&#100; out &#116;&#104;&#097;&#116; he &#104;&#097;&#100; croup. &#116;&#104;&#105;&#115; emergency room trip cost &#097;&#108;&#109;&#111;&#115;&#116; $1,000.</p>
<p>His symptoms lasted only two days and then &#116;&#104;&#101;&#121; were completely gone. About six months later he woke up in &#116;&#104;&#101; middle of &#116;&#104;&#101; night &#119;&#105;&#116;&#104; &#116;&#104;&#101; &#115;&#097;&#109;&#101; cough, &#098;&#117;&#116; &#116;&#104;&#105;&#115; time I knew &#119;&#104;&#097;&#116; &#116;&#111; do and didn&#8217;t have &#116;&#111; &#116;&#097;&#107;&#101; him &#116;&#111; &#116;&#104;&#101; doctor. He recovered quickly on &#104;&#105;&#115; &#111;&#119;&#110; after two sleepless nights. I want &#116;&#111; share our experience so &#105;&#102; &#105;&#116; &#104;&#097;&#112;&#112;&#101;&#110;&#115; &#116;&#111; &#121;&#111;&#117;, &#121;&#111;&#117; &#097;&#108;&#115;&#111; &#119;&#105;&#108;&#108; know &#119;&#104;&#097;&#116; &#116;&#111; do.</p>
<p>First of &#097;&#108;&#108;, croup is most &#111;&#102;&#116;&#101;&#110; caused &#098;&#121; &#116;&#104;&#101; &#115;&#097;&#109;&#101; viruses &#116;&#104;&#097;&#116; &#099;&#097;&#117;&#115;&#101; &#116;&#104;&#101; common &#099;&#111;&#108;&#100;. Two kids &#099;&#097;&#110; get &#116;&#104;&#101; &#115;&#097;&#109;&#101; virus, and &#111;&#110;&#101; &#119;&#105;&#108;&#108; get croup and &#116;&#104;&#101; &#111;&#116;&#104;&#101;&#114; may not. My &#111;&#116;&#104;&#101;&#114; son &#104;&#097;&#115; &#110;&#101;&#118;&#101;&#114; &#104;&#097;&#100; any symptoms of croup. &#115;&#111;&#109;&#101; children &#115;&#101;&#101;&#109; &#116;&#111; &#098;&#101; more prone &#116;&#111; &#116;&#104;&#105;&#115; illness than &#111;&#116;&#104;&#101;&#114;&#115;. Research &#104;&#097;&#115; shown &#116;&#104;&#097;&#116; children born early &#111;&#114; &#119;&#104;&#111; have breathing problems &#115;&#117;&#099;&#104; as asthma &#097;&#114;&#101; more prone &#116;&#111; &#103;&#101;&#116;&#116;&#105;&#110;&#103; croup.</p>
<p>Croup is most common in children &#117;&#110;&#100;&#101;&#114; &#116;&#104;&#114;&#101;&#101; years of age. &#116;&#104;&#101; younger &#116;&#104;&#101; child, usually &#116;&#104;&#101; worse &#116;&#104;&#101; symptoms &#097;&#114;&#101;. &#116;&#104;&#101;&#114;&#101; &#097;&#114;&#101; &#115;&#111;&#109;&#101; things &#121;&#111;&#117; &#099;&#097;&#110; do at home &#116;&#111; relieve these symptoms.</p>
<p>Your child may &#111;&#114; may not have symptoms &#098;&#101;&#102;&#111;&#114;&#101; &#116;&#104;&#101; coughing occurs. &#098;&#111;&#116;&#104; times my son was sick he &#100;&#105;&#100; not have any &#099;&#111;&#108;&#100; symptoms &#098;&#101;&#102;&#111;&#114;&#101; &#116;&#104;&#101; cough. However, &#098;&#111;&#116;&#104; times &#104;&#105;&#115; twin brother was sick &#102;&#105;&#114;&#115;&#116;, so &#119;&#101; knew he was exposed &#116;&#111; a virus. After &#116;&#104;&#101; coughing episodes, he displayed common &#099;&#111;&#108;&#100; symptoms (e.g., runny nose, coughing).</p>
<p>The barking cough is &#116;&#104;&#101; result of a narrowing of &#121;&#111;&#117;&#114; child&#8217;s air passage. &#116;&#104;&#101; effect of &#116;&#104;&#105;&#115; is worsened &#098;&#121; &#121;&#111;&#117;&#114; child&#8217;s &#099;&#114;&#121;&#105;&#110;&#103;. &#116;&#104;&#101; harder &#116;&#104;&#101;&#121; &#099;&#114;&#121;, &#116;&#104;&#101; harder &#105;&#116; is &#116;&#111; breathe. &#105;&#102; &#121;&#111;&#117;&#114; child is &#099;&#114;&#121;&#105;&#110;&#103;, &#116;&#114;&#121; &#116;&#111; &#099;&#097;&#108;&#109; him &#111;&#114; &#104;&#101;&#114; down as quickly as &#112;&#111;&#115;&#115;&#105;&#098;&#108;&#101;.</p>
<p>If &#121;&#111;&#117; see at any point &#116;&#104;&#097;&#116; &#121;&#111;&#117;&#114; child is having &#116;&#111;&#111; &#109;&#117;&#099;&#104; difficulty breathing, and &#105;&#116; appears he &#111;&#114; she is not &#103;&#101;&#116;&#116;&#105;&#110;&#103; enough oxygen, &#121;&#111;&#117; should immediately &#103;&#111; &#116;&#111; &#116;&#104;&#101; emergency room. &#105;&#102; &#105;&#116; appears &#121;&#111;&#117;&#114; child is breathing &#111;&#107;&#097;&#121; &#098;&#117;&#116; &#121;&#111;&#117; &#099;&#097;&#110;&#110;&#111;&#116; get &#116;&#104;&#101; cough &#117;&#110;&#100;&#101;&#114; control, &#116;&#104;&#101;&#114;&#101; &#097;&#114;&#101; things &#121;&#111;&#117; &#099;&#097;&#110; do &#116;&#111; help shrink &#116;&#104;&#101; air passageways.</p>
<p>Cool-mist humidifiers &#119;&#105;&#108;&#108; &#112;&#117;&#116; moisture into &#116;&#104;&#101; air and help &#121;&#111;&#117;&#114; child breathe more easily. Steam &#102;&#114;&#111;&#109; a hot shower &#119;&#105;&#108;&#108; &#097;&#108;&#115;&#111; help reduce symptoms. &#100;&#117;&#114;&#105;&#110;&#103; winter months, taking &#121;&#111;&#117;&#114; child out into &#116;&#104;&#101; &#099;&#111;&#108;&#100;, even &#105;&#102; &#105;&#116; is &#116;&#104;&#101; middle of &#116;&#104;&#101; night, is &#111;&#102;&#116;&#101;&#110; &#116;&#104;&#101; &#098;&#101;&#115;&#116; &#119;&#097;&#121; &#116;&#111; get relief &#102;&#111;&#114; &#121;&#111;&#117;&#114; child &#102;&#097;&#115;&#116;. &#102;&#111;&#114; &#115;&#111;&#109;&#101; reason &#116;&#104;&#105;&#115; croup cough only acts up at night. I was &#116;&#111;&#108;&#100; at &#116;&#104;&#101; emergency room &#116;&#104;&#097;&#116; bringing my son out into &#116;&#104;&#101; &#099;&#111;&#108;&#100; &#116;&#111; &#116;&#097;&#107;&#101; him &#116;&#111; &#116;&#104;&#101; hospital &#104;&#097;&#100; &#097;&#108;&#109;&#111;&#115;&#116; eliminated &#104;&#105;&#115; symptoms &#098;&#101;&#102;&#111;&#114;&#101; he &#103;&#111;&#116; &#116;&#104;&#101;&#114;&#101;!</p>
<p>If &#110;&#111;&#110;&#101; of these things work, as a last resort, &#116;&#104;&#101;&#114;&#101; &#097;&#114;&#101; medications a doctor &#099;&#097;&#110; give &#121;&#111;&#117;&#114; child &#116;&#111; reduce &#116;&#104;&#101; swelling &#116;&#104;&#097;&#116; is causing &#116;&#104;&#101; cough. Symptoms generally only last a couple of nights then disappear. &#105;&#116; is a good &#105;&#100;&#101;&#097; &#116;&#111; sleep in &#116;&#104;&#101; &#115;&#097;&#109;&#101; room as &#121;&#111;&#117;&#114; child while &#116;&#104;&#101;&#121; &#097;&#114;&#101; experiencing &#116;&#104;&#105;&#115; cough. &#111;&#110;&#101; night of hearing &#121;&#111;&#117;&#114; child cough &#108;&#105;&#107;&#101; &#116;&#104;&#105;&#115; and &#116;&#114;&#121;&#105;&#110;&#103; &#116;&#111; catch &#116;&#104;&#101;&#105;&#114; breath would &#099;&#097;&#117;&#115;&#101; &#121;&#111;&#117; &#116;&#111; not &#108;&#101;&#116; them out of &#121;&#111;&#117;&#114; sight! &#116;&#104;&#101; &#115;&#101;&#099;&#111;&#110;&#100; time my son &#119;&#101;&#110;&#116; through &#116;&#104;&#105;&#115; I slept in our guest room &#119;&#105;&#116;&#104; him &#119;&#105;&#116;&#104; &#116;&#104;&#101; humidifier in &#116;&#104;&#101; room and he was &#097;&#098;&#108;&#101; &#116;&#111; get comfortable enough &#116;&#111; sleep. &#116;&#104;&#101; &#110;&#101;&#120;&#116; day &#121;&#111;&#117; wouldn&#8217;t even have &#107;&#110;&#111;&#119;&#110; he was sick &#101;&#120;&#099;&#101;&#112;&#116; &#102;&#111;&#114; a &#108;&#105;&#116;&#116;&#108;&#101; bit of a runny nose.</p>
<p>Rachel Paxton is a freelance writer and mom of &#102;&#105;&#118;&#101;. &#102;&#111;&#114; resources &#102;&#111;&#114; &#116;&#104;&#101; Christian family, including parenting, toddler and preschool activities, homeschooling, family traditions, and more, visit Christian-Parent.com</p></p>
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		<title>People with Lupus Might be at a Greater Risk for Cancer</title>
		<link>http://symptomadvice.com/people-with-lupus-might-be-at-a-greater-risk-for-cancer/</link>
		<comments>http://symptomadvice.com/people-with-lupus-might-be-at-a-greater-risk-for-cancer/#comments</comments>
		<pubDate>Thu, 25 Nov 2010 22:00:11 +0000</pubDate>
		<dc:creator>Symptom Advice</dc:creator>
				<category><![CDATA[uterine symptoms]]></category>
		<category><![CDATA[arthritis]]></category>
		<category><![CDATA[chronic inflammatory disease]]></category>
		<category><![CDATA[fatigue]]></category>
		<category><![CDATA[organs]]></category>
		<category><![CDATA[sle]]></category>

		<guid isPermaLink="false">http://symptomadvice.com/people-with-lupus-might-be-at-a-greater-risk-for-cancer/</guid>
		<description><![CDATA[Newswise &#8212; People &#119;&#105;&#116;&#104; systemic lupus erythematosus are 1.15 times as &#108;&#105;&#107;&#101;&#108;&#121; to develop cancer as &#116;&#104;&#101; general population and &#109;&#111;&#114;&#101; &#116;&#104;&#097;&#110; 2.5 times as &#108;&#105;&#107;&#101;&#108;&#121; to develop hematologic malignancies, such as lymphoma and leukemia, &#097;&#099;&#099;&#111;&#114;&#100;&#105;&#110;&#103; to research presented this week at &#116;&#104;&#101; American College of Rheumatology Annual Scientific Meeting &#105;&#110; Atlanta. Systemic lupus erythematosus, [...]]]></description>
			<content:encoded><![CDATA[<p></p><p><img src="http://symptomadvice.com/wp-content/uploads/2010/11/1290722411-93.jpg" style="clear:both;clear:both;margin:0 15px 15px 0" />
<p>Newswise &#8212; People &#119;&#105;&#116;&#104; systemic lupus erythematosus are 1.15 times as &#108;&#105;&#107;&#101;&#108;&#121; to develop cancer as &#116;&#104;&#101; general population and &#109;&#111;&#114;&#101; &#116;&#104;&#097;&#110; 2.5 times as &#108;&#105;&#107;&#101;&#108;&#121; to develop hematologic malignancies, such as lymphoma and leukemia, &#097;&#099;&#099;&#111;&#114;&#100;&#105;&#110;&#103; to research presented this week at &#116;&#104;&#101; American College of Rheumatology Annual Scientific Meeting &#105;&#110; Atlanta. </p>
<p>Systemic lupus erythematosus, also called SLE or lupus, is &#097; chronic inflammatory disease &#116;&#104;&#097;&#116; can affect &#116;&#104;&#101; skin, joints, kidneys, lungs, nervous &#115;&#121;&#115;&#116;&#101;&#109;, and/or other organs of &#116;&#104;&#101; body. &#116;&#104;&#101; &#109;&#111;&#115;&#116; common symptoms include skin rashes and arthritis, &#111;&#102;&#116;&#101;&#110; accompanied by fatigue and fever. Lupus occurs mostly &#105;&#110; women, typically developing &#105;&#110; individuals &#105;&#110; their twenties and thirties – prime child-bearing age.</p>
<p>Some studies &#104;&#097;&#118;&#101; shown &#097; link between lupus and cancer risk, and researchers &#114;&#101;&#099;&#101;&#110;&#116;&#108;&#121; aimed to &#109;&#097;&#107;&#101; &#109;&#111;&#114;&#101; precise estimations of this risk. They observed 13,492 people &#119;&#105;&#116;&#104; lupus from 24 medical centers for an average of &#110;&#105;&#110;&#101; years, for &#097; total of 118,359 patient-years (number of patients multiplied by number of years of observation), and compared &#116;&#104;&#101;&#115;&#101; participants to people &#119;&#105;&#116;&#104;&#111;&#117;&#116; lupus.</p>
<p>During &#116;&#104;&#101; course of this study, 632 cases of cancer &#119;&#101;&#114;&#101; noted, and &#116;&#104;&#101; data concerning hematological cancers—cancers &#116;&#104;&#097;&#116; affect &#116;&#104;&#101; bone, blood and lymph nodes—was &#116;&#104;&#101; &#109;&#111;&#115;&#116; striking: researchers &#102;&#111;&#117;&#110;&#100; &#116;&#104;&#097;&#116; people &#119;&#105;&#116;&#104; lupus &#119;&#101;&#114;&#101; 3.2 times &#109;&#111;&#114;&#101; &#108;&#105;&#107;&#101;&#108;&#121; to develop lymphomas &#116;&#104;&#097;&#110; &#116;&#104;&#101; general population and 3.4 times &#109;&#111;&#114;&#101; &#108;&#105;&#107;&#101;&#108;&#121; to develop non-Hodgkin’s lymphoma, specifically. They also &#102;&#111;&#117;&#110;&#100; &#116;&#104;&#097;&#116; people &#119;&#105;&#116;&#104; lupus &#119;&#101;&#114;&#101; 1.7 times greater risk of developing leukemia.</p>
<p>“These results &#109;&#111;&#114;&#101; precisely define cancer risk &#105;&#110; SLE [than previous studies], highlighting &#097; higher risk of hematological malignancies – both lymphoma and leukemia,” &#115;&#097;&#121;&#115; Sasha R. Bernatsky, MD, assistant professor &#105;&#110; &#116;&#104;&#101; Department of Medicine, Divisions of Rheumatology and Clinical Epidemiology, at McGill University, &#097; medical scientist at &#116;&#104;&#101; Research Institute of &#116;&#104;&#101; McGill University Health Centre, and co-principle investigator &#105;&#110; &#116;&#104;&#101; ongoing study along &#119;&#105;&#116;&#104; Ann E. Clarke, MD, and Rosalind Ramsey-Goldman, MD, Dr.PH. “However, &#116;&#104;&#101; news may &#110;&#111;&#116; &#098;&#101; &#097;&#108;&#108; &#116;&#104;&#097;&#116; bad, &#099;&#111;&#110;&#115;&#105;&#100;&#101;&#114;&#105;&#110;&#103; &#116;&#104;&#097;&#116; hematological cancers remain &#097; rare event – &#111;&#110;&#101; &#105;&#110; every 1,250 patient-years of follow-up for &#116;&#104;&#101;&#115;&#101; patients. Just &#119;&#104;&#097;&#116; is driving &#116;&#104;&#101; risk of cancer &#105;&#110; SLE is &#115;&#116;&#105;&#108;&#108; unknown, but &#119;&#101; currently suspect &#116;&#104;&#097;&#116; disease activity plays &#097; role, although drug exposures &#104;&#097;&#118;&#101; &#110;&#111;&#116; been ruled out.”</p>
<p>Study participants also demonstrated an increased likelihood of developing lung cancer (1.2 times as &#108;&#105;&#107;&#101;&#108;&#121; as &#116;&#104;&#101; general population), cervical cancer (1.6 times &#109;&#111;&#114;&#101; likely), vulvo-vaginal cancers (2.8 times &#109;&#111;&#114;&#101; likely), and liver cancer (2. 2 times &#109;&#111;&#114;&#101; likely). &#116;&#104;&#101; study also shows &#116;&#104;&#097;&#116; people &#119;&#105;&#116;&#104; lupus &#119;&#104;&#111; are younger &#116;&#104;&#097;&#110; 40 &#104;&#097;&#118;&#101; &#097; &#112;&#097;&#114;&#116;&#105;&#099;&#117;&#108;&#097;&#114;&#108;&#121; high risk, as they are 1.7 times &#109;&#111;&#114;&#101; &#108;&#105;&#107;&#101;&#108;&#121; to develop cancer &#116;&#104;&#097;&#110; &#116;&#104;&#101; general population.</p>
<p>On &#116;&#104;&#101; other hand, participants did &#100;&#105;&#115;&#112;&#108;&#097;&#121; &#097; significantly decreased risk of developing hormone-sensitive cancers, including breast cancer (0.7 times as &#108;&#105;&#107;&#101;&#108;&#121; as &#116;&#104;&#101; general population), endometrial cancer (0.49 times &#116;&#104;&#101; likelihood), and ovarian cancer (0.56 times &#116;&#104;&#101; likelihood).</p>
<p>“The &#108;&#111;&#119;&#101;&#114; risk of several hormone-sensitive cancers may invoke &#116;&#104;&#101; possibility of alterations &#105;&#110; &#116;&#104;&#101; metabolism from estrogen and/or other hormones,” Dr. Bernatsky explains. “But, because female SLE patients may &#098;&#101; at higher risk for cancers and pre-cancerous &#099;&#104;&#097;&#110;&#103;&#101;&#115; of &#116;&#104;&#101; uterine cervix, they should &#116;&#114;&#121; to undergo pap testing regularly once they become sexually active, especially &#105;&#102; they take immunosuppressive drugs.”</p>
<p>The American College of Rheumatology is an international professional medical society &#116;&#104;&#097;&#116; represents &#109;&#111;&#114;&#101; &#116;&#104;&#097;&#110; 8,000 rheumatologists and rheumatology health professionals around &#116;&#104;&#101; world. Its mission is to advance rheumatology. &#116;&#104;&#101; ACR/ARHP Annual Scientific Meeting is &#116;&#104;&#101; premier meeting &#105;&#110; rheumatology. For &#109;&#111;&#114;&#101; information about &#116;&#104;&#101; meeting, visit rheumatology.org/education. Follow &#116;&#104;&#101; meeting &#111;&#110; twitter by using &#116;&#104;&#101; official hashtag: #ACR2010.</p>
<p>###Editor’s Notes: Dr. Bernatsky &#119;&#105;&#108;&#108; present this research &#100;&#117;&#114;&#105;&#110;&#103; &#116;&#104;&#101; ACR Annual Scientific Meeting at &#116;&#104;&#101; Georgia World Congress Center at 5:30 PM &#111;&#110; Monday, November 8 &#105;&#110; Room B 402. Dr. Bernatsky &#119;&#105;&#108;&#108; &#098;&#101; &#097;&#118;&#097;&#105;&#108;&#097;&#098;&#108;&#101; for media questions and briefing at 8:30 AM &#111;&#110; Tuesday, November 9 &#105;&#110; &#116;&#104;&#101; on-site press conference room, B 212.</p>
<p>Learn &#109;&#111;&#114;&#101; about living well &#119;&#105;&#116;&#104; rheumatic disease as well as rheumatologists and &#116;&#104;&#101; role they play &#105;&#110; health care. </p>
<p>Presentation Number: 731</p>
<p>Further Defining Cancer Risk &#105;&#110; Systemic Lupus: Updated Results &#105;&#110; an Expanded International Multi-Centre Cohort.</p>
<p>Sasha R. Bernatsky (McGill UHC/RVH, Montreal, QC, Canada)Ann E. Clarke (Montreal General Hospital, Montreal, QC, Canada)Michelle &#097;. Petri (Timonium, MD)Murray B.Urowitz (The Toronto Western Hospital, Toronto, ON, Canada)Paul R. Fortin (Toronto Western Hospital, Toronto, ON, Canada)Dafna D. Gladman (Toronto Western Hospital, Toronto, ON, Canada)Søren Jacobsen (Rigshospitalet &#8211; 4242, Copenhagen, Denmark)Susan Manzi (20West Penn Allegheny Health &#115;&#121;&#115;&#116;&#101;&#109;, Pittsburgh, PA)Graciela S. Alarcon (Oakland, CA)Ellen M. Ginzler (SUNYDownstate Medical Center, Brooklyn, NY)ChristineA. Peschken (Univ of Manitoba, Winnipeg, MB, Canada)Mary Anne Dooley (Capital Health and Dalhousie University, Chapel Hill, NC)John G. Hanly (Queen Elizabeth II Health Services Center, Halifax, NS, Canada)Ola Nived (University Hospital, Lund, Sweden)Gunnar K. Sturfelt (17UCL Div of Medicine, Room 331, 3rd Floor, Lund, Sweden)Jean-Luc Senecal (Notre-Dame Hospital, M-4243, Montreal, QC, Canada)Jeremy Labrecque (McGill University, Montreal, Canada)Elizabeth M. Turnbull (McGill University Health Ctr, Montreal, QC, Canada)Jennifer L. F. Lee (RI McGill Univ Health Ctr, Montreal, QC, Canada)Rosalind Ramsey-Goldman (Northwestern University, Chicago, IL)</p>
<p>Purpose: Our previous collaborative effort demonstrated an association between systemic lupus (SLE) and cancer, driven primarily by lymphoma risk. &#119;&#101; aimed to &#109;&#111;&#114;&#101; precisely estimate cancer incidence rates &#105;&#110; SLE, compared to &#116;&#104;&#101; general population. &#119;&#101; also present results stratified by age group.</p>
<p>Methods: &#119;&#101; assembled an expanded multi-centre international cohort of clinically confirmed SLE patients. Patients at &#101;&#097;&#099;&#104; center &#119;&#101;&#114;&#101; linked to regional tumor registries to determine cancer occurrence. Standardized incidence ratios (SIRs) &#119;&#101;&#114;&#101; calculated as &#116;&#104;&#101; ratio of observed to expected cancers. Cancers expected &#119;&#101;&#114;&#101; determined by multiplying person-years &#105;&#110; &#116;&#104;&#101; cohort by &#116;&#104;&#101; geographically matched age, sex, and calendar year-specific cancer rates, and summing over &#097;&#108;&#108; person-years.</p>
<p>Results: &#116;&#104;&#101; 13,492 patients from 24 centers &#119;&#101;&#114;&#101; observed for &#097; total of 118,359 patient-years, &#119;&#105;&#116;&#104; an average follow-up of 9 years. &#119;&#105;&#116;&#104;&#105;&#110; &#116;&#104;&#101; observation interval, 632 cancers occurred. &#116;&#104;&#101; data confirmed an increased risk of cancer among patients &#119;&#105;&#116;&#104; SLE. For &#097;&#108;&#108; cancers combined, &#116;&#104;&#101; SIR estimate was 1.15 (95% confidence interval, 95% CI, 1.06-1.24), and for &#097;&#108;&#108; hematologic malignancies combined, &#116;&#104;&#101; SIR was 2.53 (95% CI 2.05-3.07). &#114;&#101;&#103;&#097;&#114;&#100;&#105;&#110;&#103; specific types of hematological malignancies, increased risk was demonstrated for &#097;&#108;&#108; lymphomas (SIR 3.21, 95% CI 2.48-4.07) as well non-Hodgkin&#8217;s lymphoma specifically (SIR 3.41, 95% CI 2.61-4.39), and for leukemia (1.69, 95% CI 1.00-2.67). &#119;&#101; also demonstrated an increased risk of lung cancer (SIR 1.24; 95% CI 1.00-1.53), cervical cancer (SIR 1.65, 95% CI 1.09-2.41), vulvo-vaginal cancers (SIR 2.80, 95% CI 1.12-5.77), and hepatic cancer (SIR 2.18, 95% CI 1.16-3.73). &#109;&#101;&#097;&#110;&#119;&#104;&#105;&#108;&#101;, &#097; significant decreased risk was &#115;&#101;&#101;&#110; for hormone-sensitive cancers, including breast cancer (SIR 0.70, 95% CI 0.58, 0.85), endometrial cancer (SIR 0.49, 95% CI 0.27, 0.83), and ovarian cancer (0.56, 95% CI 0.28, 0.97). When SIR estimates &#119;&#101;&#114;&#101; stratified by age, SLE patients &#105;&#110; &#116;&#104;&#101; youngest age group (</p>
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