Hi

For the last month, i've been getting a constant Post nasal drip (mucus) from the back of my throat which I have to spit out like every 1 minute, the mucus is clear, bubbly and incredibly glue like (it sticks to absolutely anything Yuk!)

Also, I have a constant yellowish/whiteish, and sometimes a greenish tint coating at the back of my tongue, it is incredibly thick and I brush every day (with occasional mouthwash), but it continues

Along with the coating, there is a constant foul taste in my mouth and throat, it kinda tastes like acid (I think this "taste" is due to the coating of my tongue, I think i'm always tasting the coating on my tongue and its disgusting)

Furthermore, i've got excessive bubbly and frothy saliva which makes it hard to talk to pppl and just constantly takes over my mouth (sigh). although I belive this saliva "could" be from my body trying to neautralise all the mucus and coating on my tongue and throat, therefore creating more and more saliva, but i don't know for sure.

Sometimes, the saliva is incredibly sticky and along with the sticky mucus from my throat, it is the worst feeling ever :(

Finally, my hard palate (the bit behind my front teeth) kinda tingles just slightly if I place my tongue on it, which is rly annoying cos my tongue is there all the time. I also have some pressure on my front two teeth but not much

From time to time, I have a bad cough too

I've been to the doctors a few times, had antibiotics for sinuses- did nothing, now they think its acid reflux?? I've just started meds for it a few days ago but no improvement yet and i dont have any heartburn

I've had a lot of sinus issues in the past, but havnt really caused on going symptoms like these, could this be from my sinues?? like an undetectable infection or soemthing?? antibiotics did nothing

could acid reflux cause this????

I dnt know if this is related but all these problems started when I used a new toothpaste, which kinda dried out my mouth a lot for a week, and these issues started after. But i dont think it is because of toothpaste lol.

Im totally depressed bcos i hav to go through this everyday . im starting to perform badly in school as well and hav A LOT of anxiety. + i think anxiety is making all the symptoms worse i cant talk bcos of the excess mucus/saliva and taste in my mouth

what could cause all of this??? sinus?/ acid relfux??

is there any cure? or home remedies i can use to ATLEAST mask the symptoms, bcos they are depressing me soooo much

thanx a lot guys – from a very depressed teenager

in newborns, often "failure to thrive" and the IRT test is done, Classic CF involves malabsorption syndrome, can be meconium ileus at birth, salt residue on skin of baby, mother will say the baby tastes salty. there is a mutation in the CFTR gene , Chrome 7, usually diagnosed under age 1, can be later and can be diagnosed in adults. sx : children have undeveloped sinuses or pansinusititis, chronic "colds", congested cough, constipation or diarrhea (steatorrhea) foul, smelling , floating stools from lack of pancreatic enzymes. Some kids have diabetes early or later in life just to make things more complicated. Chronic dry to wet coughs, that has sticky mucus, that eventually entraps staph and strep and klebsiella and e.coli bacteria in the beginning and later the dreaded Pseudomonas Aeruginosa, which is everywhere, soil, standing water, occ skin, some kids get aspergillus fungal rxn and require steroids for the reaction , others are treated for the fungus. Medication and airway clearance and caloric maintenance levels is high. Numerous pancreatic enzymes for digestions, airway clearance can involve expensive meds, D-nase,or saline in addition to bronchodilators, corticosteroids and acapella or vest therapies and then inhaled Tobi, all done 2x daily or more, and often might miss school due to illness/fatigue, fevers, wt loss, decreased lung function, new bacteria in addition to treated bacteria, anemias, bone loss and freq doc appt or hos admission for picc lines/tune ups or some have port lines and g-tubes for extra feedings. Sweat tests can be negative as well as the common screening panel of 23 most common. there are over 1600 DNA mutations for Cystic Fibrosis. Children born in the USA in 1990's have better chance to live past 40yrs and older. Men that have absence of vas deferens can have CF, but not have lung/sinus sx or have 0-no sperm count. Some people, diagnosed later in life have lung/sinus symptoms just as severe and can have pancreatic preservation. I do. I was dx'd 2008 via DNA , age 50. I was a working RN, not anymore. there is no cure, it can have coughing up blood episodes, collapsed lungs, cysts on the lungs and scarring(fibrosis). Some people do lung transplants, there are not many lungs around for transplant and many are placed on a list about 1-2yrs out, if lung volumes decrease dramatically. 1:4 are carriers, the est CF population in the USA holds around 30,000, with 70,000 worldwide, some of whom don't get treatment or die before their 1st/2nd birthday. I think there are more than 30,000 USA, many are not diagnosed that should be. Ambry Genetics is the main DNA testing lab in the USA, there are otherss. Try cff.org and cfww.org.

When bacteria gets in your lungs, the immune system responds with neutrophils, the breakdown products cause more inflammation and scarring, that's the current theory. Pseudomonas can be erradicated early, but, later it stays chronic and resp sx are cause of death/elevated carbon dioxide levels, enlarged spleen,.heart, etc

some of the symptoms of CF are recurrent chest infections, failure to thrive and salty tasting sweat, there are many complications of the disease including diabetes and liver problems.

There is no cure for this horrible, vile, heartbreaking disease

Cystic Fibrosis is characterized by congestion of the throat, difficulty breathing and a nasal voice. unfortunately there is not a cure for it. but there is therapy to clear the mucus out of your lungs.

Google "cystic fibrosis".

Public release date: 17-Dec-2010 [ | E-mail | Share ] Contact: Brian Kellbkell@thoracic.org212-315-6442American Thoracic Society

Cystic fibrosis (CF) patients with normal to mildly impaired lung function may benefit from a new investigational drug designed to help prevent formation of the sticky mucus that is a hallmark of the disease, according to researchers involved in a phase 3 clinical trial of the drug. Called denufosol, the investigational medication can be given early in the CF disease process, and may help delay the progression of lung disease in these patients, the researchers found.

The findings were published online ahead of the print edition of the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

“Although the lungs of children with CF are thought to be normal at birth, studies have demonstrated significant lung damage that occurs early in life in children suffering from cystic fibrosis,” said lead investigator Frank Accurso, MD, professor of pediatrics, University of Colorado School of Medicine, Denver. “Many patients continue to suffer progressive loss of lung function despite treatment of complications. Because denufosol can be used early in life, it offers hope for delaying or preventing the progressive changes that lead to irreversible airflow obstruction in CF patients.”

Denufosol belongs to a class of drugs known as ion channel regulators. These drugs help balance the flow of ions through cell membranes, helping normalize the airway surface hydration and mucus clearance impairment present in patients who suffer from the disease. In cystic fibrosis, the ion sodium chloride does not flow normally through cell membranes, resulting in thick, sticky mucus which is difficult to cough out of the airways. In addition to causing breathing problems, the mucus becomes a breeding ground for bacteria and can cause serious respiratory infections.

Denufosol works by increasing chloride secretion, inhibiting sodium absorption and increasing the beat frequency of the tiny hairs, or “cilia,” lining the airways move to clear mucus. Combined, these effects enhance airway hydration and aid in clearing mucus. The drug is different from other CF medications, which primarily treat the symptoms rather than the underlying causes, said Dr. Accurso, who is also the director of University of Colorado’s cystic fibrosis center.

This study is the first large, phase 3 trial of an ion channel regulator in cystic fibrosis patients with little or no baseline pulmonary function impairment.

“Abnormal ion transport and defective mucociliary clearance are fundamental defects that contribute to complications of CF lung disease, including mucus plugging, chronic bacterial infection, inflammation and progressive airway damage,” Dr. Accurso noted. “Although currently available drugs target these complications, denufosol was designed to treat the underlying defects that cause the complications, and could potentially modify the course of the disease, particularly when administered early in the disease process.”

Researchers enrolled 352 cystic fibrosis patients 5 years of age or older, and enrolled them to receive either inhaled denufosol or placebo three times daily for 24 weeks, followed by a 24-week open-label period when all patients received denufosol. At baseline, most patients enrolled had mild impairment of lung function and were taking multiple medications to control their symptoms. Because the study outcomes were measured using spirometry, a lung function test that can be difficult to accurately use in young children, patients under five years of age were excluded.

Patients’ exhalation rates and lung volume were measured throughout the study, and also were monitored for adverse events, such as cough, congestion, fever or sinusitis. At the end of the 24-week period, researchers determined patients who received denufosol had better lung exhalation rates than those in the placebo group, whose exhalation volumes remained relatively unchanged from the start of the study. both groups had similar numbers and types of adverse events, with the denufosol patients experiencing significantly fewer headaches and lower rates of sinusitis and runny nose.

Although children under five years of age were excluded from this study, Dr. Accurso said future studies likely would address the use of denufosol in this younger population.

“Considering the evidence that early inflammation and infection results in impaired lung function and structural damage in early childhood, future studies of the effects of denufosol during the first 5 years of life is warranted,” he said.

A second, similar phase 3 trial incorporating a longer placebo-controlled treatment phase is ongoing to further investigate the effectiveness of denufosol in patients with CF, Dr. Accurso added.

###

[ | E-mail | Share ]  

Can you also explain where on the chromosome the mutated gene is found?
How the mutation causes physical symptoms?
If the gene is recessive, do both alleles have to be recessive or do both alleles have to be heterozygous and have a 3:1 chance or homozygous and 4:0 chance.

CFTR mutation, affects sodium chloride channel function, is amplitude related. go to CFF.org or cfww.org , sticky mucus entraps bacteria, pseudomonas (in soil/spoiled lettuce, standing water/hot tubs) which is hard to eradicate once colonized, haemophilus non influenza and staph, sometimes MRSA infections, yeast infections, worst is cepacia (which is onion rot) some kids have other syndromes, downs, aspergers and autism in addition to CF. CF affects liver, pancreas (CFRD diabetes) GI tract (malabsorption syndrome/failure to thrive)search genetics of cystic fibrosis, secondary effects of cystic fibrosis. I have it.

Go to this website all of your answers will hopefully be there