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Pancreatic cancer is a malignant disease of the Pancreas, the organ that regulates insulin levels in the body. In this disease, 95% of the cases are Adenocarcinomas, the most aggressive type of carcinoma. Survival rates are very low because the disease has usually no symptoms until in late stages.

Symptoms: Brownish urine, Clay colored stools, Nausea, Diabetes can be caused by it as well.

In late stages patients will develop a pain in the upper left abdomen that radiates towards the back.

Hi,

The Pancreatic Cancer Action Network is an excellent resource for information about pancreatic cancer symptoms, diagnosis and more.

Call toll-free 877-272-6226 M-F or

Hope you find this helpful!

Polycystic kidney disease in dogs is a geneticdisease that can eventually cause kidney failure. this condition progresses slowly and the damage it causes cannot be reversed. While this disease is not common in dogs, some breeds are more prone to it than others. Let’s learn more about the causes, symptoms, diagnosis and treatment of polycystic kidney disease in dogs. 

Polycystic kidney disease is rare in dogs. Australian bull terriers, however, are considered prone to it. Dogs are usually born with this disease, which causes small cysts to grow in the tissue of the kidney. The kidney may grow enormously in size, but its ability to function willdecrease with time as the growing cysts gradually replace the normal kidney tissue. 

Eventually, polycystic kidney disease can cause kidney failure. The symptoms are the same as they are in dogs experiencing kidney failure for other reasons. they include:

• Excessive thirst and excessive urination
• Lethargy
• Depression
• Lowered appetite or anorexia
• Weight loss
• Vomiting
• Nausea
• Bad breath
• Weakness
• Lack of coordination

Kidney failure can be deadly, so make sure your dog receives prompt veterinary care as soon as his symptoms appear. Prompt veterinary care can extend your dog’s life and improve his quality of life. There is, however, no cure for polycystic kidney disease and no way to stop the progression of this inherited disease. 

Your vet will need a thorough physical exam and a complete medical history to diagnose polycystic kidney disease in your dog. Urinalysis, as well as X-rays, ultrasounds and biopsies of kidney tissue, can help your vet evaluate the extent of the damage to your dog’s kidneys. Blood counts and biochemical profiles can help your vet determine how well your dog’s kidneys are currently functioning. 

Vets have not yet developed a treatment plan specifically for polycystic kidney disease. Your vet will recommend a generalized kidney failure treatment plan. a diet that is low in protein and phosphorus usually forms the core of such a plan.

Your vet may prescribe medications, including calcitriol, erythropoietin, and phosphorus binders. Other medications your vet mightprescribe include famotidine and cimetidine for vomiting. Your vet may prescribe steroid drugs or, if your dog is suffering from anemia, epogen. fluids administered beneath the skin can help mitigate the dehydration that many dogs with kidney failure experience.

Vets cannot slow the progression of polycystic kidney disease in dogs, nor can they reverse the damage it does to the kidneys. Once diagnosed, your dog will need to eat a specialized diet and receive medication and other care for the rest of his life. Feed your dog according to your vet’s instructions and administer all medications as directed. make sure your dog has a constant supply of clean, fresh water; if he continues to suffer form dehydration, your vet can show youhow to administer fluids by injecting them under the skin. 

Polycystic kidney disease is genetic, and dogs with polycystic kidney disease should not be bred.

also see Feline Polycystic Kidney Disease

also see Understanding Polycystic Kidney Disease in Dogs

The term “renal” refers to anything relating to the kidneys; essentially, they carry blood from the heart to the kidneys after branching off the aorta, or main artery coming off the heart, and lead to one kidney each. The volume of blood passing through these arteries is a very large amount—about 1 ½ liters of the 5 liters of blood pumped out from the heart. This blood passes through every single minute because blood is constantly flowing through the body. so, now we talk about renal artery stenosis. This is a condition in which the diameter of these arteries decreases, and there is less room for blood to flow. Learn more about this condition, including the definition, consequences, causes, symptoms, diagnosis, and treatment.

Renal Artery Stenosis: Background InformationAs mentioned above, renal artery stenosis is a condition in which the renal arteries become narrower, restricting blood flow through them. there are two different negative things that can result from this: impaired kidney function, known as renal failure, and high blood pressure, referred to as renovascular hypertension (RVHT). when one artery to the kidneys is narrowed, RVHT results; when both arteries are narrowed, renal failure results.

Renal Artery Stenosis: ConsequencesThe problems arising from renal artery stenosis can be very serious; in fact, a whole series of reactions come about because of it. when the amount of circulating blood to the kidneys is decreased, the normal physiological reaction of the kidneys is to unleash a sequence of hormonal responses; this is called the rennin-angiotensin-aldosterone system. This defense is activated against low blood pressure and low circulating blood volume, regardless of the cause.

First: when the kidneys sense the decrease in circulating blood volume, they increase the blood level of a hormone called angiotensin 2, which causes narrowing of the small blood vessel in the kidneys.

Second: along with angiotensin 2, another hormone level is increased, called aldosterone. together, these hormones promote salt retention by the kidneys in an effort to restore and maintain blood pressure and volume.

This response is only pathological when the decreased blood flow to the kidneys is a result of the narrowing of the renal arteries. since the kidneys think there is a decreased blood volume (even though there isn’t; it’s just the decreased flow to the kidneys due to the narrowing), they will forego this reaction, and end up unnecessarily increasing blood pressure.

Renal Artery Stenosis: CausesThere are a few different causes of renal artery stenosis, but one of them occurs most frequently. The most common cause is atherosclerosis, which is the narrowing and hardening of the blood vessel wall from the inside out. Risk factors for atherosclerosis include: high cholesterol, high blood pressure, age, cigarette smoking, and diabetes. other, but less common, causes of renal artery stenosis are fibromuscular dysplasia of the vessels (thickening of the blood vessel wall leads to narrower vessels), arteritis (inflammation of the blood vessel), and dissection, which is the tearing and dividing of the blood vessel wall.

Renal Artery Stenosis: SymptomsFor the most part, the symptoms of renal artery stenosis are inconspicuous. However, certain signs of the condition would include high blood pressure that doesn’t respond to treatment; severe high blood pressure developing before age 30 or after age 50; or an incidental finding of one kidney being smaller than the other (for example, found during a routine screening or a check-up for another condition).

Renal Artery Stenosis: DiagnosisThere are two types of tests to diagnose this condition: imaging tests and functional tests. Imaging test reveal a full picture of the blood vessel, allowing the doctor to visualize the extent of the narrowing. they include angiograms, MRI, and CT. Functional tests determine whether the narrowing is enough to cause kidney failure or high blood pressure; they include a plasma rennin activity test (activity of rennin is usually higher in this condition) and a captopril renogram (measures action of the kidneys after the injection of a radioactive dye).

Renal Artery Stenosis: Treatment

MedicationThe first treatment of renal artery stenosis is to treat the high blood pressure with regular medications. if kidney function worsens as a result of these medication, which can happen in some people, the medication should be stopped.

No TreatmentIf the stenosis is found only in a routine screening and no consequential problems are apparent, treatment may not be necessary; instead, occasional monitoring of the kidneys is recommended.

X-ray AngiographyIf an abnormality of the renal artery is found, x-ray angiography is done; a 75% or greater narrowing of the artery is deemed treatable. in other words, the stenosis is severe. At this time, a widening (or dilation) of the artery is done, which is often done with angioplasty, which is when a tiny balloon is inserted into the artery and inflated to widen it; a stent may also be placed in the artery.

Vascular SurgeryIn some cases, vascular surgery may be necessary, which is a repair of the artery.