Latest Depression News

An Hour of Light a Day may Brighten Mood, Improve Sleep in Elderly People with Depression

By Jennifer WarnerWebMD Health News

Reviewed by Louise Chang, MD

Jan. 3, 2011 — Exposure to bright light may ease symptoms of depression in elderly people.

A new study shows that three weeks of bright light therapy using specially designed light boxes improved symptoms of depression by as much as 54% in older adults with depression.

In addition to lifting their moods, bright light therapy improved sleep and optimized levels of the neurotransmitter serotonin. low levels of serotonin are associated with depression and often targeted by antidepressant drugs.

Researchers say it’s the first major study to show a beneficial effect of bright light therapy on treating depression in the elderly with non-seasonal major depressive disorder.

“bright light treatment may provide a viable alternative for patients who refuse, resist, or do not tolerate antidepressant treatment,” researcher Ritsaert Leiverse, MD, of the department of psychiatry at VU University Medical Center in Amsterdam, the Netherlands, and colleagues write in the Archives of General Psychiatry.

Bright Light Helps Elderly

Researchers say depression commonly causes sleep problems and other symptoms because of a disruption of the body’s natural circadian rhythms or body clock. Circadian rhythm disturbances are also frequently found among elderly people who expose themselves less frequently to bright environmental light.

Previous studies have suggested that bright light therapy can help restore circadian rhythms and target depression-related neurotransmitters in the brain.

In this study, researchers evaluated the effects of three weeks of bright light therapy in 89 adults over age 60 diagnosed with depression. The participants were randomly divided into two groups and exposed to either an hour of bright pale blue light therapy or dim red light treatment (placebo treatment) from a light box at home during the early morning hours.

After three weeks of treatment, the study showed bright light therapy improved depressive symptoms by 43%, compared with the 36% improvement found with the placebo treatment.

Three weeks after the treatment ended, researchers found symptoms of depression continued to improve among the bright light therapy group (54% improvement vs. 33% in the placebo group).

In addition, the results showed levels of the stress hormone cortisol decreased among people who received bright light therapy. Sleep quality also improved among the bright light therapy group.

Researchers say the improvements found with bright light therapy in treating depressed elderly people in this study is similar to the improvements found with antidepressant drug treatment.

SOURCE: Lieverse, R. Archives of General Psychiatry, January 2011; vol 68: pp 61-70.©2010 WebMD, LLC. All Rights Reserved.

Depression in Elderly People – Depression Symptoms, Causes, and Treatments Including Clinical and Manic Depression on MedicineNet.com

By Lia Steakley

New research published in the Journal of Clinical Oncology shows that decreases in depression among women with advanced breast cancer are associated with improved survival rates for these patients.

In the 14-year long study (subscription required), researchers had 125 women complete surveys measuring symptoms of depression at the beginning of the study and at four-month intervals for the initial year. All participants were given educational materials, and half also participated in 90-minute group sessions led by co-therapy teams. Results showed patients with improving depressive symptoms had significantly longer median survival times than those with worsening symptoms: 53.6 months compared to 25.1 months.

In the following Q&A, Stanford psychiatrist David Spiegel, MD, who was principal investigator on the study, discusses the significance of the results, the physiological connection between depression and breast cancer, and why it’s worthwhile for breast cancer patients to be screened for depression.

What are the implications of these findings?

Depression is a risk factor for shorter breast cancer survival time, just as it is associated with poorer prognosis with heart disease. this means that identifying and treating depression in cancer patients is an important part of good medical management of breast cancer. Depression is treatable, both with medication and psychotherapy. it is not simply a reaction to cancer, but rather a complicating co-morbid illness that occurs in some but not all cancer patients.

What is the physiological connection between depression and breast cancer survival?

Depression is associated with abnormalities in the stress hormone cortisol, which mobilizes glucose into the blood to prepare us to ‘fight or flee.’ Depressed people often have higher than normal cortisol levels, and they tend to lose the variation on cortisol normally seen throughout the day and night. Normal cortisol levels are four times as high in the morning as they are in the evening. Loss of this diurnal pattern also predicts shorter survival with breast cancer, a finding we published (.pdf) in the Journal of the National Cancer Institute a decade ago. Cortisol can inhibit the function of tumor suppressor genes, such as BrCA1. it is also potently immunosuppressive, and our immune systems help us to control the growth of tumors with specialized cells called natural killer (NK) cells, and others. Depression also inhibits health-related behavior, ranging from getting normal sleep and exercise to adhering with medical treatment. Depressed people are often socially avoidance, and may not get the social support they need. so in many ways, depression can worsen outcome with breast cancer.

In light of these findings, would it be worthwhile for physicians to consider screening breast cancer patients for depression?

yes, it is a complicating co-morbid condition, not a normal reaction to having cancer. Screening and aggressive treatment will improve quality of life and may well extend survival.