Cancer Research UK recently revealed that cases of oral cancer are on the rise in the United Kingdom, an increase attributed to increasing rates of infection by human papillomavirus (HPV).

For the first time, cases of oral cancer have increased above 6,000 a year. Two-thirds of the 6,200 cases that were diagnosed in the United Kingdom last year involved men.

As many as 8 in 10 Britons may become infected with HPV at a certain point in their lives. The virus is essentially harmless, except for a few strains that cause problems. one particular strain, identified as HPV-16, may lead to changes in the cell that may develop into cancer.

“We have seen a rapid increase in the number of HPV16-positive cases of oral cancer,” Richard Shaw, a Cancer Research UK expert in head and neck cancers based at the Liverpool Cancer Research UK Center, shared. “We have also noticed that patients with HPV-related oral cancers tend to be younger, are less likely to be smokers and have better outcomes from treatment than those whose tumours show no evidence of HPV. This raises questions as to exactly how these cancers develop and why they only affect a small proportion of people who are exposed.”

Sara Hiom, director of information at Cancer Research UK, said that it was important for people to become aware of the symptoms of oral cancer, as early detection of the disease increases one’s chances of survival. these symptoms include mouth ulcers that do not heal; lumps or thickening in the mouth, lips, or throat; or persistent red and white patches in the mouth.

Tags: human papillomavirus, oral cancer in UK, oral cancer virus

Fat belly? no, I just had a 39lb tumour

6:00pm Thursday 27th October 2011

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A grandmother has dropped seven dress sizes after Oxford surgeons removed one of the biggest tumours they had ever witnessed – a 39lb ovarian cyst.

the benign lump, weighing the equivalent of 17 bags of sugar, caused Jayne Grainger to swell to a dress size 24, giving her the appearance of a heavily pregnant woman.

After surgery at the Churchill Hospital, mrs Grainger shrank to a svelte size 10 and now has a new lust for life.

now the grandma, who had ignored her condition through fear and a phobia of doctors and hospitals, is about to embark on a major fundraiser to help the surgeons who treated her and inveitably saved her life.

Widow mrs Grainger first realised something was wrong when her stomach started to swell for apparently no reason.

But she said: “I was in complete denial. at that point I had no pain and no symptoms, just a tummy that was getting bigger.”

it continued to grow until a few months later her son Tim, 45 and daughter Jorgie, 37, noticed and tried to convince her to seek medical help.

But mrs Grainger said a phobia of doctors and hospitals meant she could not face it.

she said: “I couldn’t bear to look at myself in the mirror.

“Although I had this enormous stomach and swollen legs, there was no flesh on my arms or the torso.

“I used to put the rubbish out after dark and kept my car parked really close to my front door, so I could get in without anyone seeing me properly.

“My legs started to swell up too, so it looked as though I had elephantitis.

“The weight of the bump meant the pressure on my legs was unbearable.

“By the end, I could barely walk and couldn’t get down the stairs in my house.”

After working up the courage to see her doctor, mrs Grainger, whose husband Alan died from pancreatic cancer seven years ago, was referred from the Royal Berkshire Hospital in Reading, near to where she lives, to the Oxford Cancer Centre at the Churchill Hospital.

she was operated on within days and the cyst, which turned out not to be cancerous, was removed.

now mrs Grainger, who is in her 60s, is preparing to take part in Sunday’s It’s Not just A Walk In the Park, at University Parks, to raise cash for Oxford Radcliffe Hospitals Trust.

she said: “I have never felt so good – I am on a natural high because I have faced my greatest fear. the other day, I was up a ladder cutting branches off a tree and a neighbour said they wished they had my energy and looked as slim.”

Mr Roberto Tozzi was the surgeon who operated on mrs Grainger He said: “We managed to get the whole thing out without rupturing it, which was good.

“It had grown very slowly over time but she had just become accustomed to it.

“From the size of it, it was actually a relatively easy operation.

“It was one of the largest we’ve ever had in Oxford. it was a very peculiar case.”

It’s Not just A Walk In the Park starts at 10.30am on Sunday October 30. For more information and to register, visit orhcharitablefunds.nhs.uk

A quarter of cancer sufferers are being sent away by GPs with their early warning signs dismissed as minor ailments, a study reveals toTens of thousands of patients are initially told that their symptoms are ‘nothing to worry about’ or advised to take painkillers or antibiotics for months.day.

Tens of thousands of patients are initially told that their symptoms are ‘nothing to worry about’ or advised to take painkillers or antibiotics for months.

Missed disease: Thousands of cancer sufferers are forced to make repeat visits to their doctor before their symptoms are correctly identified and can be treated

They have to make repeated trips to their doctor before being given a correct diagnosis, the report concludes.

Britain has one of the lowest cancer survival rates in Europe despite billions being invested in treatment over the last decade.

Experts blame late diagnosis for the alarmingly high death rates and say many tumours are spotted only when it is too late for successful treatment.

More than half of those with rarer cancers – which comprise 50 per cent of all cases – are being forced to see their GP repeatedly before they are finally referred to a specialist.

Almost two thirds wait longer than three months between making an appointment to see their family doctor and being told that they have cancer. For many patients this delay proves fatal.

Rarer cancers comprise all forms of cancer except breast, bowel, lung and prostate, which are known as the ‘top four’.

They include kidney, thyroid and gall bladder cancer, and cancers of the blood such as myeloma, leukaemia and lymphoma. these illnesses can be difficult to diagnose as symptoms such as pain, tiredness, weight loss and lack of appetite can be explained by many other illnesses.

The study by the Rarer Cancers Foundation found that a quarter of patients are diagnosed only once the disease has already spread to other organs, by which time it is often terminal.

Last month the Coalition promised to save up to 5,000 lives a year by giving GPs the power to refer patients directly for scans and tests rather than going through a cancer specialist.

But experts warn that if family doctors do not even suspect patients have cancer, they will simply send them home reassured without asking for these tests.

RARE DISEASE DIAGNOSIS

Many Britons with genetic diseases are ‘left in the dark’ by medics, a report claims today.

Almost half of those with a so-called ‘rare diseases’ wait more than a year for diagnosis, while a further 20 per cent see at least six doctors before finding out what is wrong with them.

The delays lead to a deterioration in health, inappropriate treatment and medication and significant distress, the charity Rare Disease UK says.

A rare disease is defined as one that affects fewer than five in 10,000 of the general population.  But, while individual conditions are uncommon, together they affect 3.5million Britons – or one in 17 people at some point in their lives.

Examples include cystic fibrosis, sickle cell anaemia and muscular dystrophy.

Rare Disease UK, a coalition of more than 130 patient groups, wants research to be better funded and better co-ordinated, doctors to be better-informed of symptoms and better access to drugs, where they are available.

It also wants a national plan for the treatment of rare diseases to stress the importance of psychological support, not only for patients, but for their families too.

Dr Peter Corry, a paediatrician at St Luke’s Hospital in Bradford, said: ‘Diagnosis is often difficult and the complex treatments required may involve several specialists.‘Frontline medical staff need good sources of up-to-date information and access to the appropriate experts.’Research into the treatment of rare diseases will be showcased an open afternoon and evening at Royal Holloway, University of London today.   

Andrew Wilson, chief executive of the Rarer Cancers Foundation, said: ‘if patients are going to have the best chance of beating cancer then they need to be diagnosed as early as possible. too many opportunities to diagnose cancer are being missed, leaving patients feeling let down by their GP and the NHS.

‘The Government wants to save an additional 5,000 lives by 2014/15 and half of these should come from rarer cancers. if this goal is to be achieved, then GPs will have to raise their game. we are calling for GPs to be paid according to their performance on diagnosing cancer.’

Experts say that while GPs are very good at spotting lumps in breast of prostate cancer or recognising the symptoms of lung or bowel cancer, rarer cancers often do not have such obvious early warning signs.

Eric Low, chief executive of Myeloma UK, said: ‘they are very difficult to diagnose. we shouldn’t have a bash at GPs – we need to provide them with the resources and background information to enable them to make these diagnoses.’

Many people have told the Rarer Cancers Foundation how symptoms were misinterpreted by GPs.

One man said his wife had died of a rare cancer of the bile duct after being told by her GP to stop taking her HRT tablets.

When she returned eight months later complaining of a bad back the same doctor prescribed painkillers. less than week later she was taken to hospital and diagnosed with terminal cancer.

Another patient was told by his GP that the lump on his neck was a swollen gland. He was finally diagnosed with thyroid cancer three months later.

One woman said her mother was given a course of antibiotics after complaining of severe diarrhoea, weight loss and lack of appetite.

Her GP even appeared to chastise her for making an appointment saying: ‘There’s stuff you can buy over the counter for that.’

She saw at least three different doctors before being diagnosed with terminal cancer of the gall bladder.

Angela Skeffington, 44, died of stomach cancer after claiming her GP and ten A&E doctors missed signs of the disease. The mother of three was told she was suffering from anorexia, depression, period pain and even indigestion, and was prescribed paracetamol.

When the cancer was finally diagnosed, it had spread to her liver and lymph nodes.

Health Secretary Andrew Lansley said:‘we know that earlier diagnosis is critical to achieving better survival rates, so we’re taking action in this area where the previous government failed.’

Missed diagnosis: Mother-of-three Angela Skeffington died of stomach cancer after a GP and team A&E doctors failed to detect the disease

* A TREATMENT that causes deadly breast cancer cells to self-destruct by flooding them with a poisonous gas is being developed by British scientists.

In experiments, the gene-based therapy killed 80 per cent of breast cancer cells within two days, the International Journal of Pharmaceutics reports.

If it continues to fulfil its early promise, it could be given to women in as little as five years.

The innovative treatment is likely to be aimed at women with ‘metastatic’ cancer that has spread through the body and has stopped responding to conventional treatments.

Researcher Helen McCarthy of Queen’s University, Belfast, said: ‘For patients in this position the outcome is bleak. There is a pressing need for new and alternative therapies.’

Dr McCarthy’s research centres on inserting a gene into cancer cells.

Once inside the cells, it pumps out nitric oxide, a toxic gas that kills many of the cells outright or makes them more vulnerable to chemo and radiotherapy.

Previous research shows that flooding tumours with the poison makes them twice as sensitive to radiotherapy.

Crucially, the gene therapy method is expected to have no effect on normal healthy cells, cutting the odds of side-effects from nausea and vomiting to loss of hair.

Dr Lisa Wilde, of the Breast Cancer Campaign, which funded the research, said: ‘Gene therapy could potentially be an exciting avenue for treating breast cancer.

‘although at an early stage, Dr McCarthy’s research shows that this system for delivering toxic genes to tumour cells holds great promise.’